Early Drug Discovery Unit (EDDU)

Making connections:

Accelerating drug discovery
to improve the lives of people with neurological disease

40+Team members100+Users trained50+Academic collaborators8Industry partners

OUR MISSION

  1. Train the next generation of researchers to work with induced pluripotent stem cells (iPSCs)

  2. Translate fundamental research and technology into industry-standard assays

  3. Identify new and improved treatments for neurological disorders

WHAT WE DO

  • Collaborate with academic and industry partners to develop new Open Science tools and technologies that use iPSCs

  • Specialize in research using iPSCs and iPSC-derived cells

  • Combine expertise in patient-derived stem cells, assay development, and automated high-content screening

  • Offer iPSC-related training and protocols developed by our researchers

 


WORKING GROUPS

Our team is made up of four working groups that each focus on a different area of research.

iPSC phenotyping and CRISPR editing


Meet Carol


We are developing a library of iPSC lines in partnership with the C-BIG Repository for a variety of applications. We have expertise in:

  • iPSC phenotyping
  • CRISPR editing
  • Antibody Validation and CRISPR knockout (KO)

Researchers: Learn more

Discovery assays and screens


Meet Wolfgang


We translate fundamental research into industry-standard cell-based assays and small molecule screens. Our focus includes:

  • Parkinson's Disease and synucleinopathies
  • ALS and neuromuscular disorders
  • Neurodevelopmental disorders
  • Small molecule screening and automated image analysis

Researchers: Learn more

Organoids and tissue engineering


Meet Meghna


We develop neuronal organoids, also known as 'mini brains', which are miniature 3D models of the brain created from iPSCs. Our organoid program offers:

  • Organoid maintenance and quality control
  • 3D model development
  • Histology and 3D imaging
  • Single cell phenotyping

Researchers: Learn more

Training and outreach


Meet Rozzy

We are sharing our experiences with iPSCs and engaging with research communities in many ways:

  • “Introduction to iPSCs” hands-on workshops
  • One-on-one, hands-on training
  • Open protocols
  • iPSC Seminar Series

Researchers: Learn more


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The Neuro is a McGill research and teaching institute; delivering high quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.

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