Wayne Sossin, PhD
Wayne Sossin is interested in the specialized cellular and molecular events that shape brain function. Sossin is interested in neurodevelopmental disorders and the role that local protein synthesis in neurons plays in the origin and regulation of these disorders. In particular, the lab examines how neurons transport mRNAs to synapses as stalled ribosomes. Sossin has proposed that memories are stored using specialized synapses that can be distinguished by their molecular constituents. This proposal is being examined both in the simple nervous system of Aplysia, where behavioural memory is encoded by changes in the synaptic strength of identified neurons and in rodent models where powerful genetic tools allows for detailed correlations between molecular changes and behavior.
Anadolu M, Sun J, Li JT, Graber TE, Ortega J, Sossin WS. (2024) Puromycin reveals a distinct conformation of neuronal ribosomes (PNAS, Feb 13;121(7):e2306993121. doi: 10.1073/pnas.2306993121.
Zha C, Farah CA, Holt RJ, Ceroni F, AlAbdi L, Thuriot F, Khan AO, Helaby R, Lévesque S, Alkuraya FS, Kraus A, Ragge N, Sossin WS. (2020)Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits. Hum. Mol. Genet. 29: 3054-3063
Ferguson L, Hu J, Cai D, Chen S, Dunn TW, Pearce K, Glanzman DL, Schacher S, Sossin WS. Isoform Specificity of PKMs during Long-Term Facilitation in Aplysia Is Mediated through Stabilization by KIBRA.(2019) J. Neuroscience Oct 30;39(44):8632-8644. doi: 10.1523/JNEUROSCI.0943-19.2019. Epub 2019 Sep 19.Sossin WS and Costa-Mattioli M (2018) Translational Control in the Brain in Health and Disease. Cold Spring Harbor Perspectives in Biology doi: 10.1101/cshperspect.a032912
Sossin WS (2018) Memory synapses are distinguished by distinct molecular complexes: A proposal. Frontiers in Synaptic Neuroscience doi: 10.3389/fnsyn.2018.00005.
