Stuart Trenholm, PhD

Stuart Trenholm, PhD
Contact Information
Email address: 
stuart.trenholm [at]
Hospital title: 
Group Leader, Neural Circuits Research Group

Stuart Trenholm's lab studies how neural connectivity enables us to see objects around us. His work could discover new ways to improve the vision of people who have lost their sight by understanding how the specific wiring of neuronal circuits in the visual system leads to complex visually responsive neurons and ultimately leads to perception. The lab studies visual circuits in healthy, vision-impaired and vision-rehabilitated animals. The lab merges multiple disciplines, including physiology, animal behaviour, virology, genetics, disease models and optogenetics. Techniques in the lab include monitoring brain activity at cellular resolution using in vivo 2-photon calcium imaging, utilizing virus-mediated neuronal circuit tracing strategies, and implementing optogenetic vision restoration strategies.

Selected publications: 

Hillier D, Fiscella M, Drinnenberg A, Trenholm S, Rompani SB, Raics Z, Katona G, Juttner J, Hierlemann A, Rozsa B, Roska B (2017) Causal evidence for retina-dependent and –independent visual motion computation in mouse cortex. Nature Neuroscience. 20: 960-68.

Wertz A*, Trenholm S*, Yonehara K, Hillier D, Raics Z, Leinwieber M, Szalay G, Keller G, Rozsa B, Conzellman KK, Roska B (2015) Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules. Science. 349:70-4. *indicates equal contribution. 

Trenholm S & Awatramani GB (2015) Origins of spontaneous activity in the degenerating retina.Frontiers in Cellular Neuroscience. 9:277. doi: 10.3389.    

Trenholm S*, McLaughlin AJ*, Schwab DJ, Turner MH, Smith RG, Rieke F, Awatramani GB (2014) Non-linear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations.Nature Neuroscience. 17:1759-66. *indicates equal contribution.

Trenholm S, Schwab DJ, Balasubramanian VB, Awatramani GB (2013) Lag normalization in an electrically-coupled neural network. Nature Neuroscience. 16:154-6.

Trenholm S, Johnson K, Li X, Smith RG, Awatramani GB (2011) Parallel mechanisms encode direction in the retina. Neuron. 71:683-94.   

Research areas: 
Neural Circuits

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The Neuro (Montreal Neurological Institute-Hospital) is a bilingual academic healthcare institution. We are a McGill research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.



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