Jean Gotman, PhD
Jean Gotman’s research laboratory investigates the mechanisms of generation of epileptic discharges as recorded in the electroencephalogram (EEG) of epileptic patients. His work aims to improve both our understanding of epileptogenesis and our diagnostic techniques. Combining functional imaging techniques (fMRI) and EEG in a novel non-invasive approach, his group studies the brain regions in which abnormal activity is taking place when a discharge occurs. The laboratory also analyzes patterns of High Frequency Oscillations recently discovered in the EEG, which could improve the ability to localize epileptogenic regions and to understand better epileptogenesis.
Perucca P, Dubeau F, Gotman J. Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology. Brain. 2014 Jan;137(Pt 1):183-96
Pittau F, Dubeau F, Gotman J. Contribution of EEG/fMRI to the definition of the epileptic focus. Neurology. 2012 May 8;78(19):1479-87
Jacobs J, Zijlmans M, Zelmann R, Chatillon CE, Hall J, Olivier A, Dubeau F, Gotman J. High-frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery. Ann Neurol 67:209-220, 2010.
Tyvaert L, LeVan P, Dubeau F, Gotman J. Non-invasive dynamic imaging of seizures in epileptic patients. Human Brain Mapping 30:3993-4011, 2009.
Gotman J, Grova C, Bagshaw AP, Kobayashi E, Aghakhani Y and Dubeau F. Generalized Epileptic Discharges: Thalamo-cortical Activation and Suspension of the Default State of the Brain. Proc Natl Acad Sci USA, 102:15236-15240, 2005.