Edward Ruthazer, PhD

Edward Ruthazer, PhD
Contact Information
Email address: 
ed.ruthazer [at] mcgill.ca
Hospital title: 
James McGill Professor

Edward Ruthazer is the recipient of a Tier II Canada Research Chair, a FRQS chaire de recherche, and a James McGill Professorship. He is also the Director of the Integrated Program in Neuroscience graduate program at McGill University with about 600 full-time students.

The Ruthazer lab uses in vivo multiphoton microscopy and electrophysiology to study the development of topographic maps in the visual systems of zebrafish and Xenopus tadpoles, powerful animal models for live imaging. In particular, Dr. Ruthazer is interested in the influence of neural activity and early experience on the morphology and connectivity of the individual neurons that make up these neural maps.  He also studies how glial cells and gliotransmitters interact with neurons in the developing nervous system to modulate the structural and functional plasticity of circuits. In addition to studying these key events and molecular players in CNS development, the lab is interested in developing novel imaging and electrophysiology techniques for the study of neuronal connectivity and intracellular signalling.


Selected publications: 

Schwartz, N, Schohl, A. and Ruthazer, E.S. (2011) Activity-dependent transcription of BDNF enhances visual acuity during development. Neuron, 70(3):455-67.

*Munz M, *Gobert D, Schohl A, Poquérusse J, Podgorski K, Spratt P, Ruthazer ES (2014) Rapid Hebbian Axonal Remodeling Mediated by Visual Stimulation, Science, 344(6186): 904-9.

Sild M, Van Horn MR, Schohl A, Jia D, and Ruthazer ES (2016) Neural Activity-Dependent Regulation of Radial Glial Filopodial Motility Is Mediated by Glial cGMP-Dependent Protein Kinase 1 and Contributes to Synapse Maturation in the Developing Visual System, J Neurosci, 36:5279–5288.

Miraucourt LS, Tsui J, Gobert D, Desjardins JF, Schohl A, Sild M, Spratt P, Castonguay A, De Koninck Y, Marsh-Armstrong N, Wiseman PW and Ruthazer ES (2016) Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells. eLife, 10.7554/eLife.15932.

Van Horn, M.R., Strasser, A., Miraucourt, L.S., Pollegioni, L. and Ruthazer, E.S. (2017) The Gliotransmitter D-serine Promotes Synapse Maturation and Axonal Stabilization In Vivo. J Neurosci, 37: 6277-88.

Rahman, T.N., Munz, M., Kutsarova, E., Bilash, O.M. and Ruthazer, E.S. (2020) Stentian Structural Plasticity in the Developing Visual System. PNAS, 117: 10636-10638.

Kesner, P., Schohl, A., Warren, E., Ma, F. and Ruthazer, E.S (2020) Postsynaptic and Presynaptic NMDARs Have Distinct Roles in Neural Circuit Development. Cell Reports, 32: 107955.

Lim, T.K. and Ruthazer, E.S. (2021) Microglial Trogocytosis and the Complement System Regulate Axonal Pruning In Vivo. eLife, 10:e62167.

Li, V.J. Schohl, A., Ruthazer, E.S. (2022) Topographic map formation and the effects of NMDA receptor blockade in the developing visual system. PNAS, 119 (8) e2107899119.

Research areas: 
Neural Circuits
Neurodevelopmental Disorders
Neuroimmunological Diseases

The Neuro logo McGill logoMcGill University Health Centre logoKillam Laureates


The Neuro (Montreal Neurological Institute-Hospital) is a bilingual academic healthcare institution. We are a McGill research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.



Facebook instagram x, formerly known as twitter linkedIn youtube

Back to top