Douglas Arnold, MD

Douglas Arnold, MD
Contact Information
Email address: 
douglas.arnold [at]
Hospital title: 
Distinguished James McGill Professor
BIC Core Faculty

Dr. Douglas Arnold is a neurologist with special expertise in MRI. His personal research interests are centered on the use of advanced neuro-imaging techniques to assess the pathological evolution of multiple sclerosis and Alzheimer's disease and to quantify the effects of therapy on these diseases.

Selected publications: 

Caramanos Z, DiMaio S, Narayanan S, Lapierre Y, Arnold DL: 1H-MRSI Evidence for Cortical Gray Matter Pathology that is Independent of Cerebral White Matter Lesion Load in Patients with Secondary Progressive Multiple Sclerosis. (Journal of Neurological Sciences 2009 Feb 19.(Epub ahead of print)

Harmouche R, Arnold DL, Francis S, Collins DL, Arbel T: Bayesian MS Lesion Classification Modeling Regional and Local Spatial Information. (Medical Image Analysis – In Press)

Kezele I, Arnold DL, Collins DL: Atrophy in White Matter Fiber Tracts is not Dependent on Tract Length or Local White Matter Lesions. Multiple Sclerosis 2008;14:779-785.

Giacomini PS, Arnold DL: Non-Conventional MRI Techniques for Measuring Neuroprotection, Repair and Plasticity in Multiple Sclerosis. Current Opinion in Neurology 2008, 21(3):272-277.

Ghassemi R, Antel SB, Narayanan S, Francis SJ, Bar-Or A, Sadovnick AD, Banwell B, Arnold DL: Lesion Distribution in Children with Clinically Isolated Syndromes. Annals of Neurology, 2008; 63(3):401-405.

Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, Bar-Or A, Panzara M, Sarkar N, Agarwal S, Langer-Gould A, Smith CH for the HERMES Trial Goup: B-Cell Depletion with Rituximab in Relapsing-Remitting Multiple Sclerosis. New England Journal of Medicine, 2008; 358(7):676-688.

Chen JT, Collins DL, Atkins H, Freedman MS, Arnold DL; Canadian MS/BMT Study Group: Magnetization Transfer Ratio Evolution with Demyelination and Remyelination in Multiple Sclerosis Lesions. Annals of Neurology, 2008; 63(2):254-262.

Chen JT, Kuhlmann T, Jansen GH, Collins DL, Atkins HL, Freedman MS, O’Connor PW, Arnold DL: Voxel-based Analysis of the Evolution of Magnetization Transfer to Quantify Remyelination & Demyelination with Histopathological Validation in a Multiple Sclerosis Lesion. Neuroimage. 2007 Jul 15; 36(4):1152-1158.

Kezele IB, Chen JT, Arnold DL, Collins LB: The Relation of Focal White Matter Signal Abnormality and Focal Volume Loss in Multiple Sclerosis. Multiple Sclerosis. 2007 Jul;13(6):809-813. Epub 2007 Mar 15.

Chen JT, Collins DL, Atkins HL, Freedman MS, Galal A, Arnold DL, and the Canadian MS BMT Study Group: Brain Atrophy After Immunoablation and Stem Cell Transplantation in MS. Neurology 2006;66(12):1935-1937.

Research areas: 
Neuroimaging and Neuroinformatics
Neuroimmunological Diseases

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The Neuro (Montreal Neurological Institute-Hospital) is a bilingual academic healthcare institution. We are a McGill research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.



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