New frontiers in MS research

Patients and clinical trials are key to developing better treatments

Patients are the key to the success of new projects at The Neuro that could greatly help in treating multiple sclerosis (MS) and understanding its cause. One project involves patients and novel therapies. The other project focusses on gathering and analyzing patients’ data in a comprehensive new database.

This database is called Data Extraction in Multiple Sclerosis To Inform Future Interventions, or DEMySTIFI. It will become part of The Neuro’s C-BIG Repository, a vast collection of biological samples, imaging and genetic data from both neurological patients and healthy control subjects. The Neuro’s Open Science policy makes this data freely available to world science.

“We have such a large MS footprint at The Neuro: about four thousand patients are seen in our MS Clinic, and about 50 staff members are doing clinical and laboratory studies,” says the Dr. Paul Giacomini, the MS Clinic’s director, who is spearheading the DEMySTIFI project. “We can move the field forward meaningfully by capturing patients’ clinical data and using the new bio-repository platform to better analyze and understand the nuances of MS.”

MS develops differently depending on whether a patient has the relapsing-remitting form of the disease or the progressive form.

“Some patients have a mild form and can go years without a relapse. Others have numerous relapses despite aggressive treatment. We think the best way to understand this is to get as much data as possible and take advantage of improvements in data science, including machine learning and artificial intelligence. By teasing out the nuances from this data set, and applying what we learn, we hope to better predict who will respond well or poorly to a specific therapy.”

Dr. Giacomini and his colleagues, including Dr. Douglas Arnold and Dr. Louis Collins, expect DEMySTIFI will enable them eventually to personalize treatment selection for individual patients.

“Oncology has already moved into personalized medicine where a patient’s tumour is characterized by markers and receptors,” he says. “We hope that DEMySTIFI will give us the tools to treat MS in the same way so that each patient receives the best and safest treatment for them.”

DEMySTIFI will include data gathered from the latest MS clinical trials.

BTK inhibitors trial

“One of the latest exciting developments is an experimental therapy using BTK inhibitors,” says Dr. Alexander Saveriano, one of the neurologists who is overseeing MS clinical trials at The Neuro. “BTK inhibitors act on the effect of B cells in the central nervous system. B cells play an important role in generating inflammation in MS.”

Not all B cells contribute to this inflammation, however, and certain parts of B cells might have an anti-inflammatory effect.

“There are already approved therapies that target B cells to kill them,” says Dr. Saveriano. “BTK inhibitors affect B-cell functioning, preventing their activation. They also have effects on macrophages, a type of cell in the immune system that has important roles in MS. Another advantage is that BTK inhibitors are better able to enter the central nervous system as compared to larger antibodies that are also used to treat MS.”

The most recently approved drug in Canada for patients with relapsing-remitting MS is ofatumumab, which targets B cells.

“It’s been highly effective in clinical trials, some of which The Neuro participated in. Ofatumumab can be administered subcutaneously at home, which is an advantage over a similar effective drug, ocrelizumab, which is administered intravenously in an infusion clinic.”

So far, there are no approved BTK inhibitor treatments for MS. Dr. Saveriano wants to recruit MS patients willing to participate in BTK inhibitor clinical trials.

“We hope to get approximately 10 to 15 patients. Some patients will not be eligible, however, because they are already being treated effectively with an approved therapy.”

MS patients who would like to participate in clinical trials can get information at https://cru.mcgill.ca/ms/ or by writing to Sean Carlin: sean.carlin [at] mcgill.ca

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The Neuro is a McGill research and teaching institute; delivering high quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.

 

 

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