Gilles Plourde, MD, MSc

Gilles Plourde, MD, MSc
Contact Information
Phone: 
514-398-1917
Biography: 

In addition to providing clinical anesthetic care, I conduct research to understand how general anesthetics cause unconsciousness. Although general anesthetics have been in use for more than 150 years, their mechanisms of action are not well understood. My approach relies on either electrophysiological (EEG or sensory-evoked potentials) in both human subjects and animals, or functional brain imaging (PET or fMRI) studies in human subjects. A key element of this research is the use of drug administration methods that allow precise control of the concentration of the drug in the blood.

 

Selected publications: 

Plourde G, Arsenau F Attenuation of High-Frequency (30-200 Hz) Thalamocortical EEG Rhythms as Correlate of Anaesthetic Action: Evidence from Dexmedetomidine , Br J Anaesth, 119:1150–60, 2017 doi: 10.1093/bja/aex329

Reed SJ, Plourde G Attenuation of high-frequency (50-200 Hz) thalamocortical EEG rhythms by propofol in rats is more pronounced to the thalamus than for the cortex, 2015, PLoS ONE 10(4): e0123287. doi:10.1371/journal.pone.0123287

Verdonck, O, Reed SJ, Hall J, Gotman J, Plourde G The sensory thalamus and cerebral motor cortex are affected concurrently during induction of anesthesia with propofol - a case series with intracranial EEG recordings. Can J Anesth. 61:254-62, 2014. doi: 10.1007/s12630-013-0100-y. Epub 2014 Jan 22

Reed SJ, Plourde G, Tobin S and Chapman, CA Partial antagonism of proprofol anesthesia by physostigmine in rats is associated with potentiation of fast (80-200 Hz) oscillations in the thalamus, Br J Anaesthesia, 110:646–53, 2013 doi:10.1093/bja/aes432

Xie G, Deschamps A, Backman SB, Fiset P, Chartrand D, Dagher A, Plourde G. Critical involvement of the thalamus and precuneus during restoration of consciousness with physostigmine in humans during propofol anaesthesia: a positron emission tomography study, Br J Anaesthesia, 106:548-57, 2011

 

 

Research areas: 
Neural Circuits

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The Neuro is a McGill research and teaching institute; delivering high quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.

 

 

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