Killam Seminar Series: The Role of Synapse Diversity and Synaptome Architecture in Behaviour and Disease
Supported by the generosity of the Killam Trusts, The Neuro's Killam Seminar Series invites outstanding guest speakers whose research is of interest to the scientific community at The Neuro and McGill University.
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Seth Grant
Professor of Molecular Neuroscience, Edinburgh University
Host: timothy.kennedy [at] mcgill.ca (Tim Kennedy)
Abstract: The synaptome architecture (SA) encompasses the remarkable spatial arrangement and organization of diverse excitatory synapse types and subtypes within the mammalian brain. Diverse synapses are found within every dendrite, neuron and brain region. The SA provides a new framework for understanding how information, including behavioral patterns and cognitive representations, is encoded—shaped by the interaction between genetic and environmental factors. In this lecture, we will explore the dynamic properties of the SA throughout the lifespan, examining how it is influenced by experience and sensory input, the effects of sleep deprivation on its daily functioning, and how genetic disorders target vulnerable synapses.
