iPSC Seminars: Early Drug Discovery Unit (EDDU) (Virtual)

Event

The iPSC Seminar Series at The Neuro

Supported by Healthy Brains for Healthy Lives and STEMCELL Technologies, The Neuro’s iPSC Seminar Series welcomes trainees and senior scientists working with induced pluripotent stem cells (iPSCs) to present their cutting-edge research. The Seminar Series intends to foster collaborations within the network of laboratories working with iPSCs in Montreal, Canada and around the world.

If you, or someone you know, would be interested in presenting please contact us to secure a spot on the schedule.

To register: Eventbrite


Speaker : Martin Berryer, PhD

The Broad Institute of Harvard and MIT, USA

Talk : Automated High-Throughput Synaptic Screen in Human Induced Neurons

The synapse is a fundamental point of communication in the nervous system, and deeper insight into synaptic mechanisms is critical for our understanding of normal brain function as well as dysfunction in developmental and degenerative diseases. While diverse brain cell types can now be generated from human pluripotent stem cells in vitro, knowledge of human synaptogenesis remains incomplete. We therefore developed a novel and scalable assay for automated high-content quantification of synaptic development in vitro using human neurons and astrocytes. We employed this phenotypic screening strategy to uncover modulators of human synaptogenesis from a small molecule library and successfully identified a set of diverse compounds that increase the synaptic network connectivity in human neural co-culture. Our results demonstrate the power of phenotyping assay in human neurons derived from pluripotent stem cells and provide a robust platform for the interrogation of neuronal connectivity in developmental and degenerative diseases.

Contact Information

Contact: 
Rina Shlaifer
Organization: 
Montreal Neurological Institute-Hospital
Email: 
irina.shlaifer [at] mcgill.ca

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The Neuro (Montreal Neurological Institute-Hospital) is a bilingual academic healthcare institution. We are a McGill research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.

 

 

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