Albert Aguayo Lecture: Axon Regeneration and Functional Restoration after CNS Injuries
This annual lecture honours Dr. Albert Aguayo, OC, FRCP, Professor Emeritus founder and former Director of the Centre for the Research in Neuroscience at McGill University. A cocktail reception will follow
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Zhigang He, PhD, BM
Professor of Neurology and Ophthalmology, Boston Children’s Hospital, Harvard Medical School, USA
Abstract: Despite the tremendous progresses made following Dr. Aguayo’s pioneering work, there remains no pro-regenerative treatments in clinical settings after central nervous system (CNS) injuries in adult humans. In my talk, I will first summarize our findings on the following areas: the reasons underlying the lack of spontaneous axon regrowth after CNS injuries, the molecular pathways for promoting adult CNS axon regeneration, and the strategies for enabling functions of regenerated axons in different experimental injury models. I will then discuss our approaches and perspectives on translating experimental findings into clinical treatments for functional restoration after CNS injuries.
Bio: Zhigang He is Professor of Neurology and Ophthalmology in Boston Children’s Hospital and Harvard Medical School. He received his PhD from the University of Toronto and completed his postdoctoral research at the University of California, San Francisco. His group studies axon regeneration, neural modulation and related sensorimotor circuit mechanisms, with the goal of developing novel CNS neural repair strategies. He was a recipient of the Reeve-Irvine Research Medal in 2019 and a Visionary Award of the Greenberg END Blindness in 2020. He has the honor of being named as a Klingenstein Fellow in Neuroscience, a John Merck Scholar, a McKnight Scholar and the EJLB fellow. He is a member of the National Academy of Medicine of US.
This annual lecture honours Dr. Albert Aguayo, OC, FRCP, Professor Emeritus founder and former Director of the Centre for the Research in Neuroscience at McGill University. He is a former President of the Society for Neurosciences and the Canadian Association of Neuroscience. Dr. Aguayo also held the positions of Secretary General and President of the International Brain Research Organization ( IBRO) and been a member of many international advisory committees and editorial boards. He holds honorary degrees from the Universities of Lund (Sweden), Cordoba ( Argentina) and Queen’s and Dalhousie in Canada. Albert Aguayo’s scientific contributions concerned the regenerative capacity of the adult mammalian central nervous system