Adrien Peyrache, PhD

Adrien Peyrache, PhD
Contact Information
Alternate phone: 
Email address: 
adrien.peyrache [at]

Our thoughts, sensation, desires, emotions or even the ability to plan our lives in the long run emerge from the collective activity of billions of neurons in the brain. Understanding the organization of neuronal activity in relation to behavior is the central questions in neuroscience as even slight modifications in the brain networks can lead to debilitating brain disorders. To address these questions, one needs a model. Adrien Peyrache is studying the cognitive processes that humans use to navigate in their environment. His lab focuses on the neuronal basis of the brain's GPS in rodents as these animals are truly amazing at exploring their environments, avoiding dangerous spots and returning to their nest as quickly as needed.

Unraveling the relationship between cognitive processes and neuronal dynamics will take us one step further toward understanding the neural basis of cognitive impairments observed in disorders such as epilepsy and depression. In practice, the tools and expertise developed to answer the fundamental questions asked in the lab are used in collaborations with other teams to investigate how neuronal networks in the brain are affected in these diseases.

Selected publications: 

Transformation of the head-direction signal into a spatial code. Peyrache A, Roux L, Schieferstein N, Buzsaki G. Nature Communications,  2017; 1752. 

Cholecystokinin Neurons of the Dentate Gyrus Initiate Behavioral Response to Antidepressants
Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A and Greengard P. Neuron, 2017; 95, 564-576
Emergence of Cognition from Action. Buzsáki G, Peyrache A, Kubie J. Cold Spring Harb Symp Quant Biol., 2015

Internally-organized mechanisms of the head direction sense. Peyrache A, Lacroix M, Petersen P, Buzsaki G. Nature Neuroscience, 2015; 18(4):569-75.

Emergence of cognition from action. Buzsaki G, Peyrache A, Kubie J. Cold Spring Harb Symp Quant Biol. 2015;79:41-50.

Excitation and inhibition compete to control spiking during hippocampal ripples: intracellular study in behaving mice. English DF, Peyrache A, Stark E, Roux L, Vallentin D, Long MA, Buzsaki G. Journal of  Neuroscience 2014; 4(49):16509-17.

Spatio-temporal dynamics of neocortical excitation and inhibition during human sleep. Peyrache A, Dehghani N, Eskandar EN, Madsen JR, Anderson WS, Donoghue JA, Hochberg LR, Halgren E, Cash SS, Destexhe A. Proc Natl Acad Sci U S A 2012; 109(5):1731-6.

Inhibition recruitment in prefrontal cortex during sleep spindles and gating of hippocampal inputs. Peyrache A, Battaglia FP, Destexhe A. Proc Natl Acad Sci U S A 2011; 108(41):17207-12.

Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning. Benchenane K, Peyrache A, Khamassi M, Battaglia FP, Wiener SI. Neuron, 2010.

Replay of rule-learning related neural patterns in the prefrontal cortex during sleep. Peyrache A, Khamassi M, Benchenane K, Wiener SI, Battaglia FP. Nature Neuroscience, 2009.

Principal component analysis of ensemble recordings reveals cell assemblies at high temporal resolution. Peyrache A, Benchenane K, Khamassi M, Wiener SI, Battaglia FP.
Journal of Computational Neuroscience, 2009

Research areas: 
Neural Circuits

The Neuro logo McGill logoMcGill University Health Centre logoKillam Laureates


The Neuro (Montreal Neurological Institute-Hospital) is a bilingual academic healthcare institution. We are a McGill research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.



Facebook instagram x, formerly known as twitter linkedIn youtube

Back to top