Simon Tran

Title: 
Professor
Simon Tran
Contact Information
Phone: 
514-398-7203
514-398-4400 Ext 09182
Email address: 
simon.tran [at] mcgill.ca
Biography: 

Dr. Tran is experienced in all three fields of research: basic science, translational research, and clinical studies. He is committed to the training of graduate and postdoctoral students in the area of stem cell biology and tissue engineering. The aim of this laboratory is to identify, isolate, and characterize post-natal stem cells of the craniofacial complex (such as salivary and periodontal stem cells). We are also working on the growth and behavior of post-natal stem cell on different 3-D tissue engineered matrices. Our hypothesis is that post-natal stem cells from one tissue (such as stem cells from the bone marrow) can differentiate into cells of another tissue (such as the salivary gland) and how to translate this phenomenon into clinically useful therapies to regenerate lost salivary gland tissue of patients experiencing the disabling effects of a dry mouth (i.e. reduced salivary secretion) due to Sjogren’s Syndrome or to the damage caused to the salivary glands following irradiation treatment for head and neck cancer. In addition to providing a new understanding of tissue dynamics in health and disease, the Tran’s laboratory presents unique possibilities for the emerging field of regenerative medicine.

Areas of expertise: 
  • Tissue engineering
  • Stem cell
  • Saliva
  • Regenerative medicine
  • Translational research
  • Periodontal diseases
Research areas: 
Biomaterials, Nanobiotechnology and Tissue Engineering
Selected publications: 

1: Wang Y, Upadhyay A, Pillai S, Khayambashi P, Tran SD. Saliva as a diagnostic
specimen for SARS-CoV-2 detection: A scoping review. Oral Dis. 2022 Apr 21. doi:
10.1111/odi.14216. Epub ahead of print. PMID: 35445491.

2: Idrissi Janati A, Karp I, Von Renteln D, Bouin M, Liu Y, Tran SD, Emami E.
Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a
pilot study. Sci Rep. 2022 Apr 4;12(1):5622. doi: 10.1038/s41598-022-09587-x.
PMID: 35379861; PMCID: PMC8979950.

3: Buck E, Lee S, Gao Q, Tran SD, Tamimi F, Stone LS, Cerruti M. The Role of
Surface Chemistry in the Osseointegration of PEEK Implants. ACS Biomater Sci
Eng. 2022 Apr 11;8(4):1506-1521. doi: 10.1021/acsbiomaterials.1c01434. Epub 2022
Mar 15. PMID: 35290033.

4: Tauer JT, Al-Jallad H, Umebayashi M, Bakhsh D, Rauch D, Tran SD, Rauch F,
Hamdy R. Characterization and functional analysis of the adipose tissue-derived
stromal vascular fraction of pediatric patients with osteogenesis imperfecta.
Sci Rep. 2022 Feb 14;12(1):2414. doi: 10.1038/s41598-022-06063-4. PMID:
35165317; PMCID: PMC8844034.

5: Pham HM, Zhang Y, Munguia-Lopez JG, Tran SD. Egg White Alginate as a Novel
Scaffold Biomaterial for 3D Salivary Cell Culturing. Biomimetics (Basel). 2021
Dec 28;7(1):5. doi: 10.3390/biomimetics7010005. PMID: 35076454; PMCID:
PMC8788534.

6: Pillai S, Upadhyay A, Sayson D, Nguyen BH, Tran SD. Advances in Medical
Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare
Monitoring. Molecules. 2021 Dec 28;27(1):165. doi: 10.3390/molecules27010165.
PMID: 35011400; PMCID: PMC8746599.

7: Morsi H, Golizeh M, Brosseau N, Janati AI, Emami E, Ndao M, Tran SD.
Detection of Fusobacterium nucleatum subspecies in the saliva of pre-colorectal
cancer patients, using tandem mass spectrometry. Arch Oral Biol. 2022
Feb;134:105337. doi: 10.1016/j.archoralbio.2021.105337. Epub 2021 Dec 14.
Erratum in: Arch Oral Biol. 2022 May;137:105398. PMID: 34929558.

8: Smith S, ElKashty O, Tamimi F, Tran SD, Cerruti M. Titanium-Containing
Silicate-Based Sol-Gel Bioactive Glass: Development, Characterization, and
Applications. Langmuir. 2021 Dec 14;37(49):14243-14253. doi:
10.1021/acs.langmuir.1c01593. Epub 2021 Dec 3. PMID: 34860533.

9: Wu DT, Munguia-Lopez JG, Cho YW, Ma X, Song V, Zhu Z, Tran SD. Polymeric
Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine. Molecules.
2021 Nov 22;26(22):7043. doi: 10.3390/molecules26227043. PMID: 34834134; PMCID:
PMC8621873.

10: Hariharan A, Iyer J, Wang A, Tran SD. Tracking of Oral and Craniofacial Stem
Cells in Tissue Development, Regeneration, and Diseases. Curr Osteoporos Rep.
2021 Dec;19(6):656-668. doi: 10.1007/s11914-021-00705-8. Epub 2021 Nov 6. PMID:
34741728.

11: Kort-Mascort J, Bao G, Elkashty O, Flores-Torres S, Munguia-Lopez JG, Jiang
T, Ehrlicher AJ, Mongeau L, Tran SD, Kinsella JM. Decellularized Extracellular
Matrix Composite Hydrogel Bioinks for the Development of 3D Bioprinted Head and
Neck in Vitro Tumor Models. ACS Biomater Sci Eng. 2021 Nov 8;7(11):5288-5300.
doi: 10.1021/acsbiomaterials.1c00812. Epub 2021 Oct 18. PMID: 34661396.

12: Lin KT, Wang A, Nguyen AB, Iyer J, Tran SD. Recent Advances in Hydrogels:
Ophthalmic Applications in Cell Delivery, Vitreous Substitutes, and Ocular
Adhesives. Biomedicines. 2021 Sep 12;9(9):1203. doi:
10.3390/biomedicines9091203. PMID: 34572389; PMCID: PMC8471559.

13: Al-Hamed FS, Abu-Nada L, Rodan R, Sarrigiannidis S, Ramirez-Garcialuna JL,
Moussa H, Elkashty O, Gao Q, Basiri T, Baca L, Torres J, Rancan L, Tran SD,
Lordkipanidzé M, Kaartinen M, Badran Z, Tamimi F. Differences in platelet-rich
plasma composition influence bone healing. J Clin Periodontol. 2021
Dec;48(12):1613-1623. doi: 10.1111/jcpe.13546. Epub 2021 Sep 27. PMID: 34517437.

14: Elkashty OA, Hariharan A, Tran SD. Aging, stem cells and cancer updated.
Aging (Albany NY). 2021 Sep 11;13(17):20854-20855. doi: 10.18632/aging.203535.
Epub 2021 Sep 11. PMID: 34516403; PMCID: PMC8457615.

15: Iyer J, Hariharan A, Cao UMN, Mai CTT, Wang A, Khayambashi P, Nguyen BH,
Safi L, Tran SD. An Overview on the Histogenesis and Morphogenesis of Salivary
Gland Neoplasms and Evolving Diagnostic Approaches. Cancers (Basel). 2021 Aug
3;13(15):3910. doi: 10.3390/cancers13153910. PMID: 34359811; PMCID: PMC8345412.

16: Charbonneau AM, Åström P, Salo T, Roy S, Tran SD. Axolotls' and Mices' Oral-
Maxillofacial Trephining Wounds Heal Differently. Cells Tissues Organs.
2021;210(4):260-274. doi: 10.1159/000518036. Epub 2021 Jul 1. PMID: 34348272.

17: Al-Hamed FS, Rodan R, Ramirez-Garcialuna JL, Elkashty O, Al-Shahrani N, Tran
SD, Lordkipanidzé M, Kaartinen M, Badran Z, Tamimi F. The effect of aging on the
bone healing properties of blood plasma. Injury. 2021 Jul;52(7):1697-1708. doi:
10.1016/j.injury.2021.05.001. Epub 2021 May 9. PMID: 34049703.

18: Kishimoto N, Nguyen BH, Tran SD, Seo K. Telesimulation training applying
flipped classroom in the dental clinic for medical emergencies. J Dent Anesth
Pain Med. 2021 Apr;21(2):179-181. doi: 10.17245/jdapm.2021.21.2.179. Epub 2021
Mar 31. PMID: 33880411; PMCID: PMC8039157.

19: Elkashty OA, Tran SD. Sulforaphane as a Promising Natural Molecule for
Cancer Prevention and Treatment. Curr Med Sci. 2021 Apr;41(2):250-269. doi:
10.1007/s11596-021-2341-2. Epub 2021 Apr 20. PMID: 33877541.

20: Abughanam G, Maria OM, Tran SD. Studying Sjögren's syndrome in mice: What is
the best available model? J Oral Biol Craniofac Res. 2021 Apr-Jun;11(2):245-255.
doi: 10.1016/j.jobcr.2020.12.001. Epub 2020 Dec 8. PMID: 33665074; PMCID:
PMC7903136.

21: Khayambashi P, Iyer J, Pillai S, Upadhyay A, Zhang Y, Tran SD. Hydrogel
Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue
Engineering. Int J Mol Sci. 2021 Jan 12;22(2):684. doi: 10.3390/ijms22020684.
PMID: 33445616; PMCID: PMC7827932.

22: Pillai S, Upadhyay A, Khayambashi P, Farooq I, Sabri H, Tarar M, Lee KT,
Harb I, Zhou S, Wang Y, Tran SD. Dental 3D-Printing: Transferring Art from the
Laboratories to the Clinics. Polymers (Basel). 2021 Jan 4;13(1):157. doi:
10.3390/polym13010157. PMID: 33406617; PMCID: PMC7795531.

23: Zhang Y, Pham HM, Munguia-Lopez JG, Kinsella JM, Tran SD. The Optimization
of a Novel Hydrogel-Egg White-Alginate for 2.5D Tissue Engineering of Salivary
Spheroid-Like Structure. Molecules. 2020 Dec 6;25(23):5751. doi:
10.3390/molecules25235751. PMID: 33291221; PMCID: PMC7730374.

24: Almansoori AA, Kim B, Lee JH, Tran SD. Tissue Engineering of Oral Mucosa and
Salivary Gland: Disease Modeling and Clinical Applications. Micromachines
(Basel). 2020 Nov 30;11(12):1066. doi: 10.3390/mi11121066. PMID: 33266093;
PMCID: PMC7761376.

25: Charbonneau AM, Tran SD. 3D Cell Culture of Human Salivary Glands Using
Nature-Inspired Functional Biomaterials: The Egg Yolk Plasma and Egg White.
Materials (Basel). 2020 Oct 28;13(21):4807. doi: 10.3390/ma13214807. PMID:
33126509; PMCID: PMC7672643.

26: Upadhyay A, Pillai S, Khayambashi P, Sabri H, Lee KT, Tarar M, Zhou S, Harb
I, Tran SD. Biomimetic Aspects of Oral and Dentofacial Regeneration. Biomimetics
(Basel). 2020 Oct 12;5(4):51. doi: 10.3390/biomimetics5040051. PMID: 33053903;
PMCID: PMC7709662.

27: Al-Hamed FS, Maria OM, Phan J, Al Subaie A, Gao Q, Mansour A, Abu Nada L,
Boukhatem I, Elkashty OA, Tran SD, Lordkipanidzé M, Badran Z, Tamimi F.
Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil,
Interferes with Bone Healing and Implant Osseointegration in a Rat Model.
Biomolecules. 2020 Sep 14;10(9):1318. doi: 10.3390/biom10091318. PMID: 32937955;
PMCID: PMC7563209.

28: Elkashty OA, Tran SD. Broccoli extract increases drug-mediated cytotoxicity
towards cancer stem cells of head and neck squamous cell carcinoma. Br J Cancer.
2020 Oct;123(9):1395-1403. doi: 10.1038/s41416-020-1025-1. Epub 2020 Aug 10.
PMID: 32773768; PMCID: PMC7591858.

29: Wu DT, Wu KY, Nguyen TT, Tran SD. The impact of COVID-19 on dental education
in North America-Where do we go next? Eur J Dent Educ. 2020 Nov;24(4):825-827.
doi: 10.1111/eje.12561. Epub 2020 Jul 12. PMID: 32654328; PMCID: PMC7404882.

30: D'Agostino C, Elkashty OA, Chivasso C, Perret J, Tran SD, Delporte C.
Insight into Salivary Gland Aquaporins. Cells. 2020 Jun 25;9(6):1547. doi:
10.3390/cells9061547. PMID: 32630469; PMCID: PMC7349754.

31: Wu KY, Wu DT, Nguyen TT, Tran SD. COVID-19's impact on private practice and
academic dentistry in North America. Oral Dis. 2021 Apr;27 Suppl 3:684-687. doi:
10.1111/odi.13444. Epub 2020 Jun 16. PMID: 32472974; PMCID: PMC7300727.

32: Su X, Liu Y, Bakkar M, ElKashty O, El-Hakim M, Seuntjens J, Tran SD. Labial
Stem Cell Extract Mitigates Injury to Irradiated Salivary Glands. J Dent Res.
2020 Mar;99(3):293-301. doi: 10.1177/0022034519898138. Epub 2020 Jan 14. PMID:
31937182.

33: Elkashty OA, Abu Elghanam G, Su X, Liu Y, Chauvin PJ, Tran SD. Cancer stem
cells enrichment with surface markers CD271 and CD44 in human head and neck
squamous cell carcinomas. Carcinogenesis. 2020 Jun 17;41(4):458-466. doi:
10.1093/carcin/bgz182. PMID: 31742606; PMCID: PMC7298622.

34: Elkashty OA, Ashry R, Tran SD. Head and neck cancer management and cancer
stem cells implication. Saudi Dent J. 2019 Oct;31(4):395-416. doi:
10.1016/j.sdentj.2019.05.010. Epub 2019 Jun 10. PMID: 31700218; PMCID:
PMC6823822.

35: Charbonneau AM, Kinsella JM, Tran SD. 3D Cultures of Salivary Gland Cells in
Native or Gelled Egg Yolk Plasma, Combined with Egg White and 3D-Printing of
Gelled Egg Yolk Plasma. Materials (Basel). 2019 Oct 24;12(21):3480. doi:
10.3390/ma12213480. PMID: 31652954; PMCID: PMC6861896.

36: I T, Sumita Y, Yoshida T, Honma R, Iwatake M, Raudales JLM, Shizuno T,
Kuroshima S, Masuda H, Seki M, Tran SD, Asahara T, Asahina I. Anti-inflammatory
and vasculogenic conditioning of peripheral blood mononuclear cells reinforces
their therapeutic potential for radiation-injured salivary glands. Stem Cell Res
Ther. 2019 Oct 17;10(1):304. doi: 10.1186/s13287-019-1414-7. PMID: 31623661;
PMCID: PMC6798785.

37: Mantha S, Pillai S, Khayambashi P, Upadhyay A, Zhang Y, Tao O, Pham HM, Tran
SD. Smart Hydrogels in Tissue Engineering and Regenerative Medicine. Materials
(Basel). 2019 Oct 12;12(20):3323. doi: 10.3390/ma12203323. PMID: 31614735;
PMCID: PMC6829293.

38: Abughanam G, Elkashty OA, Liu Y, Bakkar MO, Tran SD. Mesenchymal Stem Cells
Extract (MSCsE)-Based Therapy Alleviates Xerostomia and Keratoconjunctivitis
Sicca in Sjogren's Syndrome-Like Disease. Int J Mol Sci. 2019 Sep
25;20(19):4750. doi: 10.3390/ijms20194750. Erratum in: Int J Mol Sci. 2021 Jan
18;22(2): PMID: 31557796; PMCID: PMC6801785.

39: Tran SD, Bakkar MO, Sumita Y, Kishimoto N. Regenerative dentistry in
periodontics. Saudi Dent J. 2019 Jul;31(3):301-302. doi:
10.1016/j.sdentj.2019.05.002. Epub 2019 May 13. PMID: 31337930; PMCID:
PMC6626286.

40: Tao O, Kort-Mascort J, Lin Y, Pham HM, Charbonneau AM, ElKashty OA, Kinsella
JM, Tran SD. The Applications of 3D Printing for Craniofacial Tissue
Engineering. Micromachines (Basel). 2019 Jul 17;10(7):480. doi:
10.3390/mi10070480. PMID: 31319522; PMCID: PMC6680740.

41: Charbonneau AM, Al-Samadi A, Salo T, Tran SD. 3D Culture Histology
Cryosectioned Well Insert Technology Preserves the Structural Relationship
between Cells and Biomaterials for Time-Lapse Analysis of 3D Cultures.
Biotechnol J. 2019 Nov;14(11):e1900105. doi: 10.1002/biot.201900105. Epub 2019
Aug 2. PMID: 31294920.

42: Seo YJ, Lilliu MA, Abu Elghanam G, Nguyen TT, Liu Y, Lee JC, Presley JF,
Zeitouni A, El-Hakim M, Tran SD. Cell culture of differentiated human salivary
epithelial cells in a serum-free and scalable suspension system: The salivary
functional units model. J Tissue Eng Regen Med. 2019 Sep;13(9):1559-1570. doi:
10.1002/term.2908. Epub 2019 Jul 2. PMID: 31151134.

43: Mansour A, Abu-Nada L, Al-Waeli H, Mezour MA, Abdallah MN, Kinsella JM,
Kort-Mascort J, Henderson JE, Ramirez-Garcialuna JL, Tran SD, Elkashty OA, Mousa
A, El-Hadad AA, Taqi D, Al-Hamad F, Alageel O, Kaartinen MT, Tamimi F. Bone
extracts immunomodulate and enhance the regenerative performance of dicalcium
phosphates bioceramics. Acta Biomater. 2019 Apr 15;89:343-358. doi:
10.1016/j.actbio.2019.03.012. Epub 2019 Mar 8. PMID: 30853609.

44: Lin Y, Umebayashi M, Abdallah MN, Dong G, Roskies MG, Zhao YF, Murshed M,
Zhang Z, Tran SD. Combination of polyetherketoneketone scaffold and human
mesenchymal stem cells from temporomandibular joint synovial fluid enhances bone
regeneration. Sci Rep. 2019 Jan 24;9(1):472. doi: 10.1038/s41598-018-36778-2.
PMID: 30679553; PMCID: PMC6345789.

45: Kumari A, Wu DT, Motiani KK, Wu KY, Palumbo M, Tran SD. Career pathways and
professional skills of postgraduate students from a dental research-intensive
programme. Eur J Dent Educ. 2019 May;23(2):143-150. doi: 10.1111/eje.12413. Epub
2019 Jan 17. PMID: 30582648.

46: Elkashty OA, Ashry R, Elghanam GA, Pham HM, Su X, Stegen C, Tran SD.
Broccoli extract improves chemotherapeutic drug efficacy against head-neck
squamous cell carcinomas. Med Oncol. 2018 Aug 4;35(9):124. doi:
10.1007/s12032-018-1186-4. PMID: 30078069.

47: Lin LC, Elkashty O, Ramamoorthi M, Trinh N, Liu Y, Sunavala-Dossabhoy G,
Pranzatelli T, Michael DG, Chivasso C, Perret J, Chiorini JA, Delporte C, Tran
SD. Cross-contamination of the human salivary gland HSG cell line with HeLa
cells: A STR analysis study. Oral Dis. 2018 Nov;24(8):1477-1483. doi:
10.1111/odi.12920. Epub 2018 Jul 10. PMID: 29923277.

48: Abdallah MN, Abughanam G, Tran SD, Sheikh Z, Mezour MA, Basiri T, Xiao Y,
Cerruti M, Siqueira WL, Tamimi F. Comparative adsorption profiles of basal
lamina proteome and gingival cells onto dental and titanium surfaces. Acta
Biomater. 2018 Jun;73:547-558. doi: 10.1016/j.actbio.2018.04.017. Epub 2018 Apr
13. PMID: 29660511.

49: Su X, Fang D, Liu Y, Ruan G, Seuntjens J, Kinsella JM, Tran SD. Lyophilized
bone marrow cell extract functionally restores irradiation-injured salivary
glands. Oral Dis. 2018 Mar;24(1-2):202-206. doi: 10.1111/odi.12728. PMID:
29480601.

50: Kishimoto N, Honda Y, Momota Y, Tran SD. Dedifferentiated Fat (DFAT) cells:
A cell source for oral and maxillofacial tissue engineering. Oral Dis. 2018
Oct;24(7):1161-1167. doi: 10.1111/odi.12832. Epub 2018 Apr 24. PMID: 29356251.

51: Fang D, Su X, Liu Y, Lee JC, Seuntjens J, Tran SD. Cell extracts from spleen
and adipose tissues restore function to irradiation-injured salivary glands. J
Tissue Eng Regen Med. 2018 Feb;12(2):e1289-e1296. doi: 10.1002/term.2567. Epub
2017 Nov 27. PMID: 29178627.

52: Kâ K, Rousseau MC, Tran SD, Henderson M, Nicolau B. Association between
metabolic syndrome and gingival inflammation in obese children. Int J Dent Hyg.
2018 Aug;16(3):397-403. doi: 10.1111/idh.12322. Epub 2017 Nov 10. PMID:
29124887.

53: Roskies MG, Fang D, Abdallah MN, Charbonneau AM, Cohen N, Jordan JO, Hier
MP, Mlynarek A, Tamimi F, Tran SD. Three-dimensionally printed
polyetherketoneketone scaffolds with mesenchymal stem cells for the
reconstruction of critical-sized mandibular defects. Laryngoscope. 2017
Nov;127(11):E392-E398. doi: 10.1002/lary.26781. Epub 2017 Aug 4. PMID: 28776691.

54: Fang D, Shang S, Liu Y, Bakkar M, Sumita Y, Seuntjens J, Tran SD. Optimal
timing and frequency of bone marrow soup therapy for functional restoration of
salivary glands injured by single-dose or fractionated irradiation. J Tissue Eng
Regen Med. 2018 Feb;12(2):e1195-e1205. doi: 10.1002/term.2513. Epub 2017 Nov 8.
PMID: 28714550.

55: Abdallah MN, Abdollahi S, Laurenti M, Fang D, Tran SD, Cerruti M, Tamimi F.
Scaffolds for epithelial tissue engineering customized in elastomeric molds. J
Biomed Mater Res B Appl Biomater. 2018 Feb;106(2):880-890. doi:
10.1002/jbm.b.33897. Epub 2017 Apr 18. PMID: 28419685.

56: Abdallah MN, Tran SD, Abughanam G, Laurenti M, Zuanazzi D, Mezour MA, Xiao
Y, Cerruti M, Siqueira WL, Tamimi F. Biomaterial surface proteomic signature
determines interaction with epithelial cells. Acta Biomater. 2017
May;54:150-163. doi: 10.1016/j.actbio.2017.02.044. Epub 2017 Mar 1. PMID:
28259836.

57: Fang D, Roskies M, Abdallah MN, Bakkar M, Jordan J, Lin LC, Tamimi F, Tran
SD. Three-Dimensional Printed Scaffolds with Multipotent Mesenchymal Stromal
Cells for Rabbit Mandibular Reconstruction and Engineering. Methods Mol Biol.
2017;1553:273-291. doi: 10.1007/978-1-4939-6756-8_22. PMID: 28229424.

58: Bakkar M, Liu Y, Fang D, Stegen C, Su X, Ramamoorthi M, Lin LC, Kawasaki T,
Makhoul N, Pham H, Sumita Y, Tran SD. A Simplified and Systematic Method to
Isolate, Culture, and Characterize Multiple Types of Human Dental Stem Cells
from a Single Tooth. Methods Mol Biol. 2017;1553:191-207. doi:
10.1007/978-1-4939-6756-8_15. PMID: 28229417.

59: Elghanam GA, Liu Y, Khalili S, Fang D, Tran SD. Compact Bone-Derived
Multipotent Mesenchymal Stromal Cells (MSCs) for the Treatment of Sjogren's-like
Disease in NOD Mice. Methods Mol Biol. 2017;1553:25-39. doi:
10.1007/978-1-4939-6756-8_3. PMID: 28229405.

60: Charbonneau AM, Roy S, Tran SD. Oral-Facial Tissue Reconstruction in the
Regenerative Axolotl. J Exp Zool B Mol Dev Evol. 2016 Dec;326(8):489-502. doi:
10.1002/jez.b.22723. PMID: 28121390.

61: Vorstenbosch J, Nguyen CM, Zhou S, Seo YJ, Siblini A, Finnson KW, Bizet AA,
Tran SD, Philip A. Overexpression of CD109 in the Epidermis Differentially
Regulates ALK1 Versus ALK5 Signaling and Modulates Extracellular Matrix
Synthesis in the Skin. J Invest Dermatol. 2017 Mar;137(3):641-649. doi:
10.1016/j.jid.2016.09.039. Epub 2016 Nov 17. PMID: 27866969.

62: Tran SD, Nguyen BH. Human umbilical cord blood hematopoietic stem cell
expansion by the RNA-binding protein Musashi-2. Oral Dis. 2017
Jul;23(5):548-550. doi: 10.1111/odi.12548. Epub 2016 Aug 11. PMID: 27454802.

63: Su X, Fang D, Liu Y, Ramamoorthi M, Zeitouni A, Chen W, Tran SD. Three-
dimensional organotypic culture of human salivary glands: the slice culture
model. Oral Dis. 2016 Oct;22(7):639-48. doi: 10.1111/odi.12508. Epub 2016 Jul 4.
PMID: 27214128.

64: Maria OM, Liu Y, El-Hakim M, Zeitouni A, Tran SD. The role of human
fibronectin- or placenta basement membrane extract-based gels in favouring the
formation of polarized salivary acinar-like structures. J Tissue Eng Regen Med.
2017 Sep;11(9):2643-2657. doi: 10.1002/term.2164. Epub 2016 May 3. PMID:
27138462.

65: Roskies M, Jordan JO, Fang D, Abdallah MN, Hier MP, Mlynarek A, Tamimi F,
Tran SD. Improving PEEK bioactivity for craniofacial reconstruction using a 3D
printed scaffold embedded with mesenchymal stem cells. J Biomater Appl. 2016
Jul;31(1):132-9. doi: 10.1177/0885328216638636. Epub 2016 Mar 14. PMID:
26980549.

66: Javaid MA, Ahmed AS, Durand R, Tran SD. Saliva as a diagnostic tool for oral
and systemic diseases. J Oral Biol Craniofac Res. 2016 Jan-Apr;6(1):66-75. doi:
10.1016/j.jobcr.2015.08.006. Epub 2015 Sep 9. PMID: 26937373; PMCID: PMC4756071.

67: Lilliu MA, Seo YJ, Isola M, Charbonneau AM, Zeitouni A, El-Hakim M, Tran SD.
Natural extracellular matrix scaffolds recycled from human salivary digests: a
morphometric study. Oral Dis. 2016 May;22(4):313-23. doi: 10.1111/odi.12444.
Epub 2016 Feb 11. PMID: 26785831.

68: Nguyen CM, Kim JW, Quan VH, Nguyen BH, Tran SD. Periodontal associations in
cardiovascular diseases: The latest evidence and understanding. J Oral Biol
Craniofac Res. 2015 Sep-Dec;5(3):203-6. doi: 10.1016/j.jobcr.2015.06.008. Epub
2015 Jul 29. PMID: 26587382; PMCID: PMC4623887.

69: Fang D, Hu S, Liu Y, Quan VH, Seuntjens J, Tran SD. Identification of the
active components in Bone Marrow Soup: a mitigator against irradiation-injury to
salivary glands. Sci Rep. 2015 Nov 3;5:16017. doi: 10.1038/srep16017. PMID:
26526154; PMCID: PMC4630618.

70: Kawasaki T, Sumita Y, Egashira K, Ohba S, Kagami H, Tran SD, Asahina I.
Transient Exposure to Hypoxic and Anoxic Oxygen Concentrations Promotes Either
Osteogenic or Ligamentogenic Characteristics of PDL Cells. Biores Open Access.
2015 Feb 1;4(1):175-87. doi: 10.1089/biores.2014.0049. PMID: 26309794; PMCID:
PMC4497711.

71: Xia D, Qu X, Tran SD, Schmidt LL, Qin L, Zhang C, Cui X, Deng D, Wang S.
Histological characteristics following a long-term nitrate-rich diet in
miniature pigs with parotid atrophy. Int J Clin Exp Pathol. 2015 Jun
1;8(6):6225-34. Erratum in: Int J Clin Exp Pathol. 2019 Dec 01;12(12):4405-4406.
PMID: 26261499; PMCID: PMC4525833.

72: Ramamoorthi M, Bakkar M, Jordan J, Tran SD. Osteogenic Potential of Dental
Mesenchymal Stem Cells in Preclinical Studies: A Systematic Review Using
Modified ARRIVE and CONSORT Guidelines. Stem Cells Int. 2015;2015:378368. doi:
10.1155/2015/378368. Epub 2015 May 28. PMID: 26106427; PMCID: PMC4464683.

73: Xie X, Hu K, Fang D, Shang L, Tran SD, Cerruti M. Graphene and
hydroxyapatite self-assemble into homogeneous, free standing nanocomposite
hydrogels for bone tissue engineering. Nanoscale. 2015 May 7;7(17):7992-8002.
doi: 10.1039/c5nr01107h. PMID: 25864935.

74: Beaudin A, Emami E, Palumbo M, Tran SD. Quality of supervision: postgraduate
dental research trainees' perspectives. Eur J Dent Educ. 2016 Feb;20(1):32-8.
doi: 10.1111/eje.12137. Epub 2015 Jan 6. PMID: 25564935.

75: Arellano-Garcia ME, Misuno K, Tran SD, Hu S. Interferon-γ induces
immunoproteasomes and the presentation of MHC I-associated peptides on human
salivary gland cells. PLoS One. 2014 Aug 7;9(8):e102878. doi:
10.1371/journal.pone.0102878. PMID: 25102056; PMCID: PMC4125149.

76: I T, Sumita Y, Minamizato T, Umebayashi M, Liu Y, Tran SD, Asahina I. Bone
Marrow-derived Cell Therapy for Oral Mucosal Repair after Irradiation. J Dent
Res. 2014 Aug;93(8):813-20. doi: 10.1177/0022034514541124. Epub 2014 Jun 30.
PMID: 24980658; PMCID: PMC4293762.

77: Denis JF, Lévesque M, Tran SD, Camarda AJ, Roy S. Axolotl as a Model to
Study Scarless Wound Healing in Vertebrates: Role of the Transforming Growth
Factor Beta Signaling Pathway. Adv Wound Care (New Rochelle). 2013
Jun;2(5):250-260. doi: 10.1089/wound.2012.0371. PMID: 24527347; PMCID:
PMC3857354.

78: Misuno K, Tran SD, Khalili S, Huang J, Liu Y, Hu S. Quantitative analysis of
protein and gene expression in salivary glands of Sjogren's-like disease NOD
mice treated by bone marrow soup. PLoS One. 2014 Jan 29;9(1):e87158. doi:
10.1371/journal.pone.0087158. PMID: 24489858; PMCID: PMC3906116.

79: Kâ K, Rousseau MC, Tran SD, Kaartinen MT, Myneni VD, Henderson M, Nicolau B.
Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour
necrosis factor-α in children. J Clin Periodontol. 2014 May;41(5):467-72. doi:
10.1111/jcpe.12232. Epub 2014 Feb 17. PMID: 24460774.

80: Khalili S, Faustman DL, Liu Y, Sumita Y, Blank D, Peterson A, Kodama S, Tran
SD. Treatment for salivary gland hypofunction at both initial and advanced
stages of Sjögren-like disease: a comparative study of bone marrow therapy
versus spleen cell therapy with a 1-year monitoring period. Cytotherapy. 2014
Mar;16(3):412-23. doi: 10.1016/j.jcyt.2013.10.006. Epub 2014 Jan 9. PMID:
24411591.

81: Xia D, Sumita Y, Liu Y, Tai Y, Wang J, Uehara M, Agata H, Kagami H, Fan Z,
Asahina I, Wang S, Tran SD. GDFs promote tenogenic characteristics on human
periodontal ligament-derived cells in culture at late passages. Growth Factors.
2013 Oct;31(5):165-73. doi: 10.3109/08977194.2013.830611. PMID: 24079397.

82: Khosravi R, Ka K, Huang T, Khalili S, Nguyen BH, Nicolau B, Tran SD. Tumor
necrosis factor- α and interleukin-6: potential interorgan inflammatory
mediators contributing to destructive periodontal disease in obesity or
metabolic syndrome. Mediators Inflamm. 2013;2013:728987. doi:
10.1155/2013/728987. Epub 2013 Aug 28. PMID: 24068858; PMCID: PMC3771422.

83: Maria OM, Maria SM, Redman RS, Maria AM, Saad El-Din TA, Soussa EF, Tran SD.
Effects of double ligation of Stensen's duct on the rabbit parotid gland.
Biotech Histochem. 2014 Apr;89(3):181-98. doi: 10.3109/10520295.2013.832798.
Epub 2013 Sep 23. PMID: 24053197.

84: Kâ K, Rousseau MC, Lambert M, Tremblay A, Tran SD, Henderson M, Nicolau B.
Metabolic syndrome and gingival inflammation in Caucasian children with a family
history of obesity. J Clin Periodontol. 2013 Nov;40(11):986-93. doi:
10.1111/jcpe.12146. Epub 2013 Aug 26. PMID: 23980866.

85: Durand R, Tran SD, Mui B, Voyer R. Managing postoperative pain following
periodontal surgery. J Can Dent Assoc. 2013;79:d66. PMID: 23920074.

86: Tran SD, Liu Y, Xia D, Maria OM, Khalili S, Wang RW, Quan VH, Hu S,
Seuntjens J. Paracrine effects of bone marrow soup restore organ function,
regeneration, and repair in salivary glands damaged by irradiation. PLoS One.
2013 Apr 24;8(4):e61632. doi: 10.1371/journal.pone.0061632. PMID: 23637870;
PMCID: PMC3634855.

87: Nguyen TT, Mui B, Mehrabzadeh M, Chea Y, Chaudhry Z, Chaudhry K, Tran SD.
Regeneration of tissues of the oral complex: current clinical trends and
research advances. J Can Dent Assoc. 2013;79:d1. PMID: 23522126.

88: Tamimi F, Comeau P, Le Nihouannen D, Zhang YL, Bassett DC, Khalili S,
Gbureck U, Tran SD, Komarova S, Barralet JE. Perfluorodecalin and bone
regeneration. Eur Cell Mater. 2013 Jan 2;25:22-36. doi: 10.22203/ecm.v025a02.
PMID: 23283637.

89: Khalili S, Liu Y, Kornete M, Roescher N, Kodama S, Peterson A, Piccirillo
CA, Tran SD. Mesenchymal stromal cells improve salivary function and reduce
lymphocytic infiltrates in mice with Sjögren's-like disease. PLoS One.
2012;7(6):e38615. doi: 10.1371/journal.pone.0038615. Epub 2012 Jun 7. PMID:
22685592; PMCID: PMC3369846.

90: Alajbeg I, Falcão DP, Tran SD, Martín-Granizo R, Lafaurie GI, Matranga D,
Pejda S, Vuletić L, Mantilla R, Leal SC, Bezerra AC, Ménard HA, Kimoto S, Pan S,
Maniegas L, Krushinski CA, Melilli D, Campisi G, Paderni C, Mendoza GR, Yepes
JF, Lindh L, Koray M, Mumcu G, Elad S, Zeevi I, Barrios BC, López Sánchez RM,
Lassauzay C, Fromentin O, Beiski BZ, Strietzel FP, Konttinen YT, Wolff A, Zunt
SL. Intraoral electrostimulator for xerostomia relief: a long-term, multicenter,
open-label, uncontrolled, clinical trial. Oral Surg Oral Med Oral Pathol Oral
Radiol. 2012 Jun;113(6):773-81. doi: 10.1016/j.oooo.2012.01.012. PMID: 22668705.

91: Maria OM, Maria AM, Cai Y, Tran SD. Cell surface markers CD44 and CD166
localized specific populations of salivary acinar cells. Oral Dis. 2012
Mar;18(2):162-8. doi: 10.1111/j.1601-0825.2011.01858.x. Epub 2011 Oct 5. PMID:
21973167.

92: Kuriki Y, Liu Y, Xia D, Gjerde EM, Khalili S, Mui B, Zheng C, Tran SD.
Cannulation of the mouse submandibular salivary gland via the Wharton's duct. J
Vis Exp. 2011 May 14;(51):3074. doi: 10.3791/3074. PMID: 21610677; PMCID:
PMC3197132.

93: Maria OM, Maria O, Liu Y, Komarova SV, Tran SD. Matrigel improves functional
properties of human submandibular salivary gland cell line. Int J Biochem Cell
Biol. 2011 Apr;43(4):622-31. doi: 10.1016/j.biocel.2011.01.001. Epub 2011 Jan 7.
PMID: 21216302.

94: Maria OM, Zeitouni A, Gologan O, Tran SD. Matrigel improves functional
properties of primary human salivary gland cells. Tissue Eng Part A. 2011
May;17(9-10):1229-38. doi: 10.1089/ten.TEA.2010.0297. Epub 2011 Feb 8. PMID:
21189069.

95: Maria OM, Tran SD. Human mesenchymal stem cells cultured with salivary gland
biopsies adopt an epithelial phenotype. Stem Cells Dev. 2011 Jun;20(6):959-67.
doi: 10.1089/scd.2010.0214. Epub 2011 Feb 10. PMID: 21187001.

96: Tran SD, Sumita Y, Khalili S. Bone marrow-derived cells: A potential
approach for the treatment of xerostomia. Int J Biochem Cell Biol. 2011
Jan;43(1):5-9. doi: 10.1016/j.biocel.2010.10.010. Epub 2010 Oct 28. PMID:
21035563.

Tran SD, Sumita Y, Khalili S, Bone Marrow Derived Cells: a Potential Approach for the Treatment of Xerostomia. International Journal Biochemistry Cell Biology. 2011;43:5-9.

Sumita Y, Liu Y, Khalili S, Maria OM, Xia D, Key S, Mezey E, Tran SD. Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation. International Journal Biochemistry Cell Biology. 2011;43:80-7.

Tran SD, Redman RS, Barrett AJ, Pavletic SZ, Key S, Liu Y, Carpenter A, Nguyen HM, Sumita Y, Baum BJ, Pillemer SR, Mezey E. Microchimerism in salivary glands after blood- and marrow-derived stem cell transplantation. Biology Blood Marrow Transplantation. 2011;17:429-33.

Strietzel FP, Lafaurie GI, Bautista Mendoza GR, Alajbeg I, Pejda S, Vuletić L, Mantilla R, Falcão DP, Leal SC, Barreto Bezerra AC, Tran SD, Ménard HA, Kimoto S, Pan S, et al. Efficacy and safety of an intraoral electrostimulation device for xerostomia relief: A multicenter randomized trial. Arthritis Rheumatism. 2011;63:180-90.

Maria OM, Maria O, Liu Y, Komarova SV, Tran SD. Matrigel improves functional properties of human submandibular gland cell line. International Journal Biochemistry Cell Biology. 2011;43:622-31.

Nguyen T, El-Hakim M, Arseneau R, Tran SD. L’ostéonécrose des maxillaires associée aux bisphosphonates, un dépliant d’information destiné au personnel des soins dentaires et leurs patients. Journal Ordre Dentistes Quebec 2011;48:7-14

Khalili S, Liu Y, Sumita Y, Maria OM, Blank D, Key S, Mezey E, Tran SD. Bone marrow cells are a source of undifferentiated cells to prevent Sjögren's syndrome and to preserve salivary glands function in the non-obese diabetic mice. International Journal Biochemistry Cell Biology. 2010;42:1893-99.

roozbeh.kh [at] gmail.com (Khosravi)R, TranSD, LambertM, O'loughlinJ, Ka K, FeineJS, CaronC, TremblayA, Nicolau B. Adiposity and gingival crevicular fluid tumour necrosis factor-alpha levels in children. Journal Clinical Periodontology. 2009;36:301-7.

Maria OM, Kim JW, Gerstenhaber JA, Baum BJ, Tran SD. Distribution of tight junction proteins in adult human salivary glands. Journal Histochemical Cytochemistry. 2008;56:1093-8.

Dai M, Li Y, Head TW, McKee MD, Tran SD. Point of Care: Dental management of patients on oral bisphosphonate. Journal Canadian Dental Association. 2008;74:617-18.

Khosravi R, Kim MJW, Vilela LD, Greenspoon J, Thibodeau EA, Khalili S, Tran SD: Le lien entre les maladies parodontales et l’obésité. Journal Ordre Dentistes Quebec 2007;44:169-172.

Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Khalili S, Faustman DL, Mezey E. Reversal of Sjogren's-like syndrome in non-obese diabetic mice. Annals Rheumatic Diseases. 2007;66:812-4.

Maria OM, Khosravi R, Mezey E, Tran SD. Cells from bone marrow that evolve into oral tissues and their clinical applications. Oral Diseases. 2007;13:11-6.

Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E. Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice. Science. 2006;314:1243

Tran SD, Sugito T, Dipasquale G, Cotrim AP, Bandyopadhyay BC, Riddle K, Mooney D, Kok MR, Chiorini JA, Baum BJ. Re-engineering Primary Epithelial Cells from Rhesus Monkey Parotid Glands for Use in Developing an Artificial Salivary Gland. Tissue Engineering. 2006; 12:2939-48.

Baum BJ, Tran SD. Synergy between genetic and tissue engineering: creating an artificial salivary gland. Periodontology 2000. 2006;41:218-23.

Crain BJ, Tran SD, Mezey E. Transplanted human bone marrow cells generate new brain cells. Journal Neurological Science. 2005;233:121-3.

Tran SD, Wang J, Bandyopadhyay BC, Redman RS, Dutra A, Pak E, Swaim WD, Gerstenhaber JA, Bryant JM, Zheng C, Goldsmith CM, Kok MR, Wellner RB, Baum BJ. Primary culture of polarized human salivary epithelial cells for use in developing an artificial salivary gland. Tissue Engineering. 2005;11:172-81.

Kok MR, Voutetakis A, Yamano S, Wang J, Cotrim A, Katano H, Bossis I, Chiorini JA, Tran SD, Tak PP, Baum BJ. Immune responses following salivary gland administration of recombinant adeno-associated virus serotype 2 vectors. Journal Gene Medicine. 2005;7:432-41.

Tran SD, Pillemer SR, Dutra A, Barrett AJ, Brownstein MJ, Key S, Pak E, Leakan RA, Kingman A, Yamada KM, Baum BJ, Mezey E. Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet. 2003;361:1084-8.

Aframian DJ, Tran SD, Cukierman E, Yamada KM, Baum BJ. Absence of tight junction formation in an allogeneic graft cell line used for developing an engineered artificial salivary gland. Tissue Engineering. 2002;8:871-8.

Tran H, Pankov R, Tran SD, Hampton B, Burgess WH, Yamada KM. Integrin clustering induces kinectin accumulation. Journal Cell Science. 2002;115:2031-40.

Baum BJ, Kok M, Tran SD, Yamano S. The impact of gene therapy on dentistry: a revisiting after six years. Journal American Dental Association. 2002;133:35-44.

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