Marc O. Martel

Title: 
Assistant Professor
Marc O. Martel
Salutation: 
Dr
Contact Information
Email address: 
marc.o.martel [at] mcgill.ca
Biography: 

My primary line of research is designed to explore the psychological and biological determinants of prescription opioid misuse and addiction among patients with chronic pain who are prescribed opioid medications. As a parallel line of research, I am conducting research examining the factors associated with cannabis use problems in patients with chronic pain. Some of the key research methods and procedures used in my lab include self-report questionnaires, electronic diaries, structured clinical interviews, and quantitative sensory testing (QST). The bulk of my research projects are conducted in collaboration with clinicians and researchers from the Alan Edwards Pain Management Unit (AEPMU) and the Alan Edwards Center for Research on Pain (AECRP).

Areas of expertise: 
  • Pain
  • Chronic pain
  • Opioid misuse & addiction
  • Mental health
  • Biopsychosocial factors
Research areas: 
Pain and Neuroscience
Selected publications: 

PEER-REVIEWED JOURNAL ARTICLES

66. Frimerman L, Verner M, Sirois A, Scott K, Bruneau A, Perez J, Shir Y, Martel MO. Implications of opioid-related hedonic effects for clinical practice: A reply to Blatt (Accepted/in-press, PAIN).

65. Bruneau A, Frimerman L, Verner M, Sirois A, Fournier C, Scott K, Perez J, Shir Y, Martel MO. Day-to-day opioid withdrawal symptoms, psychological distress, and opioid craving in patients with chronic pain prescribed opioid therapy. Drug Alcohol Depend. 2021 Aug 1;225:108787. doi: 10.1016/j.drugalcdep.2021.108787. Epub 2021 May 29. PMID: 34091157.

64. Kaboré JL, Pagé MG, Martel MO, Dassieu L, Hudspith M, Moor G, Sutton K, Roy JS, Williamson OD, Choinière M. Impact of the Opioid Epidemic and Associated Prescribing Restrictions on People Who Live With Chronic Noncancer Pain in Canada. Clin J Pain. 2021 Aug 1;37(8):607-615. doi: 10.1097/AJP.0000000000000951. PMID: 34054062.

63. Razaghizad A, Windle SB, Filion KB, Gore G, Kudrina I, Paraskevopoulos E, Kimmelman J, Martel MO, Eisenberg MJ. The Effect of Overdose Education and Naloxone Distribution: An Umbrella Review of Systematic Reviews. Am J Public Health. 2021 Jul 2:e1-e12. doi: 10.2105/AJPH.2021.306306. Epub ahead of print. PMID: 34214412.

62. Herrero Babiloni A, Beetz G, Bruneau A, Martel MO, Cistulli PA, Nixdorf DR, Conway JM, Lavigne GJ. Multitargeting the sleep-pain interaction with pharmacological approaches: A narrative review with suggestions on new avenues of investigation. Sleep Med Rev. 2021 Jan 28;59:101459. doi: 10.1016/j.smrv.2021.101459. Epub ahead of print. PMID: 33601274.

61. Longtin C, Décary S, Cook CE, Martel MO, Lafrenaye S, Carlesso LC, Naye F, Tousignant-Laflamme Y. Optimizing management of low back pain through the pain and disability drivers management model: A feasibility trial. PLoS One. 2021 Jan 20;16(1):e0245689. doi: 10.1371/journal.pone.0245689. PMID: 33471827; PMCID: PMC7817044.

60. Martel MO, Bruneau A, Edwards RR. Mind-body approaches targeting the psychological aspects of opioid use problems in patients with chronic pain: evidence and opportunities. Transl Res. 2021 Aug;234:114-128. doi: 10.1016/j.trsl.2021.02.013. Epub 2021 Mar 3. PMID: 33676035.

59. Silva J, Coffee Z, Ho Alex Yu C, Martel MO. Anxiety and Fear Avoidance Beliefs and Behavior May Be Significant Risk Factors for Chronic Opioid Analgesic Therapy Reliance for Patients with Chronic Pain: Results from a Preliminary Study. Pain Med. 2021 Epub ahead of print. PMID: 33595642.

58. Frimerman L, Verner M, Sirois A, Scott K, Bruneau A, Perez J, Shir Y, Martel MO. Day-to-day hedonic and calming effects of opioids, opioid craving, and opioid misuse among patients with chronic pain prescribed long-term opioid therapy (Accepted/in-press, PAIN). doi: 10.1097/j.pain.0000000000002220.

57. Herrero Babiloni A, Beetz G, Tang NK, Heinzer R, Nijs J, Martel MO, Lavigne GJ. Towards the endotyping of the sleep-pain interaction: a topical review on multitarget strategies based on phenotypic vulnerabilities and putative pathways. Pain. 2020 doi: 10.1097/j.pain.0000000000002124. Epub ahead of print.

56. Herrero Babiloni A, Bellemare A, Beetz G, Vinet SA, Martel MO, Lavigne GJ, De Beaumont L. The effects of non-invasive brain stimulation on sleep disturbances among different neurological and neuropsychiatric conditions: A systematic review. Sleep Med Rev. 2020 Sep 14;55:101381. doi: 10.1016/j.smrv.2020.101381.

55. Martel MO, Edwards RR, Jamison RN. The relative contribution of pain and psychological factors to opioid misuse: A 6-month observational study. Am Psychol. 2020 Sep;75(6):772-783. doi: 10.1037/amp0000632.

54. Pagé MG, Kudrina I, Zomahoun HTV, Croteau J, Ziegler D, Ngangue P, Martin E, Fortier M, Boisvert EE, Beaulieu P, Charbonneau C, Cogan J, Daoust R, Martel MO, Néron A, Richebé P, Clarke H. A Systematic Review of the Relative Frequency and Risk Factors for Prolonged Opioid Prescription Following Surgery and Trauma Among Adults. Ann Surg. 2020 May;271(5):845-854. doi: 10.1097/SLA.0000000000003403.

53. Herrero Babiloni A, Beetz G, Dal Fabbro C, Martel MO, Huynh N, Masse JF, Sessle B, Lavigne GJ. Dental sleep medicine: Time to incorporate sleep apnoea education in the dental curriculum. Eur J Dent Educ. 2020 Apr 22. doi: 10.1111/eje.12533.

52. Bérubé M, Moore L, Lauzier F, Côté C, Vogt K, Tremblay L, Martel MO, Pagé G, Tardif PA, Pinard AM, Hameed SM, Perreault K, Sirois C, Bélanger C, Turgeon AF. Strategies aimed at preventing chronic opioid use in trauma and acute care surgery: a scoping review protocol. BMJ Open. 2020 Apr 14;10(4):e035268. doi: 10.1136/bmjopen-2019-035268.

51. Lavigne GJ, Herrero Babiloni A, Mayer P, Daoust R, Martel MO. Thoughts on the 2019 American Academy of Sleep Medicine position statement on chronic opioid therapy and sleep. J Clin Sleep Med. 2020 May 15;16(5):831-833. doi: 10.5664/jcsm.8368.

50. El-Kefraoui C, Olleik G, Chay MA, Kouyoumdjian A, Nguyen-Powanda P, Rajabiyazdi F, Do U, Derksen A, Landry T, Amar-Zifkin A, Ramanakumar AV, Martel MO, Baldini G, Feldman L, Fiore JF Jr. Opioid versus opioid-free analgesia after surgical discharge: protocol for a systematic review and meta-analysis. BMJ Open. 2020 Feb 2;10(1):e035443. doi: 10.1136/bmjopen-2019-035443.

49. Carriere JS, Lazaridou A, Martel MO, Cornelius M, Campbell C, Smith M, Haythornthwaite JA, Edwards RR. The moderating role of pain catastrophizing on the relationship between partner support and pain intensity: a daily diary study in patients with knee osteoarthritis. J Behav Med. 2019 Dec 11. doi: 10.1007/s10865-019-00121-5.

48. Herrero Babiloni A, De Koninck BP, Beetz G, De Beaumont L, Martel MO, Lavigne GJ. Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship. J Neural Transm (Vienna). 2020 Apr;127(4):647-660. doi: 10.1007/s00702-019-02067-z.

47. Tousignant-Laflamme Y, Cook CE, Mathieu A, Naye F, Wellens F, Wideman T, Martel MO, Lam OT. Operationalization of the new Pain and Disability Drivers Management model: A modified Delphi survey of multidisciplinary pain management experts. J Eval Clin Pract. 2020 Feb;26(1):316-325. doi: 10.1111/jep.13190.

46. Nandi M, Schreiber KL, Martel MO, Cornelius M, Campbell CM, Haythornthwaite JA, Smith MT Jr, Wright J, Aglio LS, Strichartz G, Edwards RR. Sex differences in negative affect and postoperative pain in patients undergoing total knee arthroplasty. Biol Sex Differ. 2019 May 6;10(1):23. doi: 10.1186/s13293-019-0237-7.

45. Lazaridou A, Martel MO, Cornelius M, Franceschelli O, Campbell C, Smith M, Haythornthwaite JA, Wright JR, Edwards RR. The Association Between Daily physical Activity and Pain Among Patients with Knee Osteoarthritis: The Moderating Role of Pain Catastrophizing. Pain Med. 2019 May 1;20(5):916-924. doi: 10.1093/pm/pny129.

44. Pagé MG, Ziemianski D, Martel MO, Shir Y. Development and validation of the Treatment Expectations in Chronic Pain Scale. Br J Health Psychol. 2019 Sep;24(3):610 628. doi: 10.1111/bjhp.12371.

43. Wideman TH, Edwards RR, Walton DM, Martel MO, Hudon A, Seminowicz DA. The Multimodal Assessment Model of Pain: A Novel Framework for Further Integrating the Subjective Pain Experience Within Research and Practice. Clin J Pain. 2019 Mar;35(3):212-221. doi: 10.1097/AJP.0000000000000670.

42. Carriere JS, Martel MO, Meints SM, Cornelius MC, Edwards RR. What do you expect? Catastrophizing mediates associations between expectancies and pain- facilitatory processes. Eur J Pain. 2019 Apr;23(4):800-811. doi: 10.1002/ejp.1348.

41. Martel MO, Petersen K, Cornelius M, Arendt-Nielsen L, Edwards R. Endogenous Pain Modulation Profiles Among Individuals With Chronic Pain: Relation to Opioid Use. J Pain. 2019 Apr;20(4):462-471. doi: 10.1016/j.jpain.2018.10.004. Epub 2018 Oct 29.

40. Pagé MG, Kudrina I, Zomahoun HTV, Ziegler D, Beaulieu P, Charbonneau C, Cogan J, Daoust R, Martel MO, Néron A, Richebé P, Clarke H. Relative frequency and risk factors for long-term opioid therapy following surgery and trauma among adults: a systematic review protocol. Syst Rev. 2018 Jul 18;7(1):97. doi: 10.1186/s13643-018-0760-3.

39. Lazaridou A, Martel MO, Cahalan CM, Cornelius MC, Franceschelli O, Campbell CM, Haythornthwaite JA, Smith M, Riley J, Edwards RR. The impact of anxiety and catastrophizing on interleukin-6 responses to acute painful stress. J Pain Res. 2018 Mar 28;11:637-647. doi: 10.2147/JPR.S147735.

38. Ware MA, Martel MO, Jovey R, Lynch ME, Singer J. A prospective observational study of problematic oral cannabinoid use. Psychopharmacology (Berl). 2018 Feb;235(2):409-417. doi: 10.1007/s00213-017-4811-6.

37. Tousignant-Laflamme Y, Martel MO, Joshi AB, Cook CE. Rehabilitation management of low back pain - it's time to pull it all together! J Pain Res. 2017 Oct 3;10:2373-2385. doi: 10.2147/JPR.S146485.

36. Finan PH, Carroll CP, Moscou-Jackson G, Martel MO, Campbell CM, Pressman A, Smyth JM, Tremblay JM, Lanzkron SM, Haythornthwaite JA. Daily Opioid Use Fluctuates as a Function of Pain, Catastrophizing, and Affect in Patients With Sickle Cell Disease: An Electronic Daily Diary Analysis. J Pain. 2018 Jan;19(1):46-56. doi: 10.1016/j.jpain.2017.08.010.

35. Martel MO, Shir Y, Ware MA. Substance-related disorders: A review of prevalence and correlates among patients with chronic pain. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Dec 20;87(Pt B):245-254. doi: 10.1016/j.pnpbp.2017.06.032.

34. Carriere JS, Martel MO, Kao MC, Sullivan MJ, Darnall BD. Pain behavior mediates the relationship between perceived injustice and opioid prescription for chronic pain: a Collaborative Health Outcomes Information Registry study. J Pain Res. 2017 Mar 7;10:557-566. doi: 10.2147/JPR.S128184.

33. Jamison RN, Dorado K, Mei A, Edwards RR, Martel MO. Influence of opioid- related side effects on disability, mood, and opioid misuse risk among patients with chronic pain in primary care. Pain Rep. 2017 Mar 6;2(2):e589. doi: 10.1097/PR9.0000000000000589.

32. Vachon-Presseau E, Roy M, Woo CW, Kunz M, Martel MO, Sullivan MJ, Jackson PL, Wager TD, Rainville P. Multiple faces of pain: effects of chronic pain on the brain regulation of facial expression. Pain. 2016 Aug;157(8):1819-30. doi: 10.1097/j.pain.0000000000000587.

31. Edwards RR, Dolman AJ, Martel MO, Finan PH, Lazaridou A, Cornelius M, Wasan AD. Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis. BMC Musculoskelet Disord. 2016 Jul 13;17:284. doi: 10.1186/s12891-016-1124-6.

30. McHugh RK, Weiss RD, Cornelius M, Martel MO, Jamison RN, Edwards RR. Distress Intolerance and Prescription Opioid Misuse Among Patients With Chronic Pain. J Pain. 2016 Jul;17(7):806-14. doi: 10.1016/j.jpain.2016.03.004.

29. Martel MO, Finan PH, McHugh RK, Issa M, Edwards RR, Jamison RN, Wasan AD. Day-to-day pain symptoms are only weakly associated with opioid craving among patients with chronic pain prescribed opioid therapy. Drug Alcohol Depend. 2016 May 1;162:130-6. doi: 10.1016/j.drugalcdep.2016.02.047.

28. Edwards RR, Dolman AJ, Michna E, Katz JN, Nedeljkovic SS, Janfaza D, Isaac Z, Martel MO, Jamison RN, Wasan AD. Changes in Pain Sensitivity and Pain Modulation During Oral Opioid Treatment: The Impact of Negative Affect. Pain Med. 2016 Oct;17(10):1882-1891. doi: 10.1093/pm/pnw010.

27. Martel MO, Olesen AE, Jørgensen D, Nielsen LM, Brock C, Edwards RR, Drewes AM. Does catastrophic thinking enhance oesophageal pain sensitivity? An experimental investigation. Eur J Pain. 2016 Sep;20(8):1214-22. doi: 10.1002/ejp.845.

26. Jamison RN, Martel MO, Huang CC, Jurcik D, Edwards RR. Efficacy of the Opioid Compliance Checklist to Monitor Chronic Pain Patients Receiving Opioid Therapy in Primary Care. J Pain. 2016 Apr;17(4):414-23. doi: 10.1016/j.jpain.2015.12.004.

25. Martel MO, Finan PH, Dolman AJ, Subramanian S, Edwards RR, Wasan AD, Jamison RN. Self-reports of medication side effects and pain-related activity interference in patients with chronic pain: a longitudinal cohort study. Pain. 2015 Jun;156(6):1092-100. doi: 10.1097/j.pain.0000000000000154.

24. Loggia ML, Berna C, Kim J, Cahalan CM, Martel MO, Gollub RL, Wasan AD, Napadow V, Edwards RR. The lateral prefrontal cortex mediates the hyperalgesic effects of negative cognitions in chronic pain patients. J Pain. 2015 Aug;16(8):692-9. doi: 10.1016/j.jpain.2015.04.003.

23. Basaria S, Travison TG, Alford D, Knapp PE, Teeter K, Cahalan C, Eder R, Lakshman K, Bachman E, Mensing G, Martel MO, Le D, Stroh H, Bhasin S, Wasan AD, Edwards RR. Effects of testosterone replacement in men with opioid-induced androgen deficiency: a randomized controlled trial. Pain. 2015 Feb;156(2):280-8. doi: 10.1097/01.j.pain.0000460308.86819.aa.

22. Schreiber KL, Campbell C, Martel MO, Greenbaum S, Wasan AD, Borsook D, Jamison RN, Edwards RR. Distraction analgesia in chronic pain patients: the impact of catastrophizing. Anesthesiology. 2014 Dec;121(6):1292-301. doi: 10.1097/ALN.0000000000000465.

21. Jamison RN, Martel MO, Edwards RR, Qian J, Sheehan KA, Ross EL. Validation of a brief Opioid Compliance Checklist for patients with chronic pain. J Pain. 2014 Nov;15(11):1092-1101. doi: 10.1016/j.jpain.2014.07.007.

20. Martel MO, Jamison RN, Wasan AD, Edwards RR. The association between catastrophizing and craving in patients with chronic pain prescribed opioid therapy: a preliminary analysis. Pain Med. 2014 Oct;15(10):1757-64. doi: 10.1111/pme.12416.

19. Vachon-Presseau E, Roy M, Martel MO, Albouy G, Sullivan MJ, Jackson PL, Rainville P. The two sides of pain communication: effects of pain expressiveness on vicarious brain responses revealed in chronic back pain patients. J Pain. 2013 Nov;14(11):1407-15. doi: 10.1016/j.jpain.2013.07.015.

18. Martel MO, Dolman AJ, Edwards RR, Jamison RN, Wasan AD. The association between negative affect and prescription opioid misuse in patients with chronic pain: the mediating role of opioid craving. J Pain. 2014 Jan;15(1):90-100. doi: 10.1016/j.jpain.2013.09.014.

17. Martel MO, Wasan AD, Edwards RR. Sex differences in the stability of conditioned pain modulation (CPM) among patients with chronic pain. Pain Med. 2013 Nov;14(11):1757-68. doi: 10.1111/pme.12220.

16. Martel MO, Wasan AD, Jamison RN, Edwards RR. Catastrophic thinking and increased risk for prescription opioid misuse in patients with chronic pain. Drug Alcohol Depend. 2013 Sep 1;132(1-2):335-41. doi: 10.1016/j.drugalcdep.2013.02.034.

15. Vachon-Presseau E, Martel MO, Roy M, Caron E, Albouy G, Marin MF, Plante I, Sullivan MJ, Lupien SJ, Rainville P. Acute stress contributes to individual differences in pain and pain-related brain activity in healthy and chronic pain patients. J Neurosci. 2013 Apr 17;33(16):6826-33. doi: 10.1523/JNEUROSCI.4584-12.2013.

14. Vachon-Presseau E, Roy M, Martel MO, Caron E, Marin MF, Chen J, Albouy G, Plante I, Sullivan MJ, Lupien SJ, Rainville P. The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans. Brain. 2013 Mar;136(Pt 3):815-27. doi: 10.1093/brain/aws371.

13. Schreiber KL, Martel MO, Shnol H, Shaffer JR, Greco C, Viray N, Taylor LN, McLaughlin M, Brufsky A, Ahrendt G, Bovbjerg D, Edwards RR, Belfer I. Persistent pain in postmastectomy patients: comparison of psychophysical, medical, surgical, and psychosocial characteristics between patients with and without pain. Pain. 2013 May;154(5):660-8. doi: 10.1016/j.pain.2012.11.015.

12. Martel MO, Trost Z, Sullivan MJ. The expression of pain behaviors in high catastrophizers: the influence of automatic and controlled processes. J Pain. 2012 Aug;13(8):808-15. doi: 10.1016/j.jpain.2012.05.015.

11. Vachon-Presseau E, Roy M, Martel MO, Albouy G, Chen J, Budell L, Sullivan MJ, Jackson PL, Rainville P. Neural processing of sensory and emotional-communicative information associated with the perception of vicarious pain. Neuroimage. 2012 Oct 15;63(1):54-62. doi: 10.1016/j.neuroimage.2012.06.030.

10. Wideman TH, Scott W, Martel MO, Sullivan MJ. Recovery from depressive symptoms over the course of physical therapy: a prospective cohort study of individuals with work-related orthopaedic injuries and symptoms of depression. J Orthop Sports Phys Ther. 2012 Nov;42(11):957-67. doi: 10.2519/jospt.2012.4182.

9. Martel MO, Wideman TH, Sullivan MJ. Patients who display protective pain behaviors are viewed as less likable, less dependable, and less likely to return to work. Pain. 2012 Apr;153(4):843-9. doi: 10.1016/j.pain.2012.01.007.

8. Sullivan MJ, Adams H, Martel MO, Scott W, Wideman T. Catastrophizing and perceived injustice: risk factors for the transition to chronicity after whiplash injury. Spine (Phila Pa 1976). 2011 Dec 1;36(25 Suppl):S244-9. doi: 10.1097/BRS.0b013e3182387fed.

7. Vachon-Presseau E, Martel MO, Roy M, Caron E, Jackson PL, Rainville P. The multilevel organization of vicarious pain responses: effects of pain cues and empathy traits on spinal nociception and acute pain. Pain. 2011 Jul;152(7):1525-31. doi: 10.1016/j.pain.2011.02.039.

6. Martel MO, Thibault P, Sullivan MJ. Judgments about pain intensity and pain genuineness: the role of pain behavior and judgmental heuristics. J Pain. 2011 Apr;12(4):468-75. doi: 10.1016/j.jpain.2010.10.010.

5. Martel MO, Thibault P, Sullivan MJ. The persistence of pain behaviors in patients with chronic back pain is independent of pain and psychological factors. Pain. 2010 Nov;151(2):330-6. doi: 10.1016/j.pain.2010.07.004.

4. Michaliszyn D, Marchand A, Bouchard S, Martel MO, Poirier-Bisson J. A randomized, controlled clinical trial of in virtuo and in vivo exposure for spider phobia. Cyberpsychol Behav Soc Netw. 2010 Dec;13(6):689-95. doi: 10.1089/cyber.2009.0277.

3. Martel MO, Thibault P, Roy C, Catchlove R, Sullivan MJ. Contextual determinants of pain judgments. Pain. 2008 Oct 31;139(3):562-8. doi: 10.1016/j.pain.2008.06.010.

2. Sullivan MJ, Martel MO, Tripp DA, Savard A, Crombez G. Catastrophic thinking and heightened perception of pain in others. Pain. 2006 Jul;123(1-2):37-44. doi: 10.1016/j.pain.2006.02.007.

1. Sullivan MJ, Martel MO, Tripp D, Savard A, Crombez G. The relation between catastrophizing and the communication of pain experience. Pain. 2006 Jun;122(3):282-8. doi: 10.1016/j.pain.2006.02.001.

Follow us on:

Back to top