Jake Barralet

Jake Barralet
Contact Information
Email address: 
jake.barralet [at] mcgill.ca

Dr Barralet is a Materials Science graduate who specialised in Biomaterials during his PhD at the Interdisciplinary Research Centre in Biomedical Materials, QMW, University of London. After a postdoctoral position with Professor Aoki at Tokyo Medical and Dental University he worked at Smith and Nephew Group Research Centre, York, UK developing bone graft and casting materials. At the University of Birmingham UK he progressed research themes in tissue engineering and bone grafts in collaboration with biologist and clinical co-workers.

He specialises in Bioceramics in particular low temperature syntheses of nanocrystalline and amorphous inorganics, cold setting materials (cements) and precipitation to create new or improved materials or devices for tissue repair or delivery. Work on tissue engineering has focussed on new ways to build 3D structures using microscaffolds as building blocks for macroscale constructs. In addition calcium cross linked alginate has been evaluated as a tissue engineering scaffold. He has been awarded a Canada Research Chair in Osteoinductive Biomaterials and will work on this topic as well as extending prior work to include biomineralisation.

Areas of expertise: 
  • Biomaterials
  • Drug delivery
  • Tissue regeneration
Research areas: 
Biomaterials, Nanobiotechnology and Tissue Engineering
Selected publications: 


Barralet JE, Best S, Bonfield W. Carbonate Hydroxyapatite Gel Monolith formation and Drying. Biomed. Mater. and Eng., 9:101-112 1996

Barralet JE, Best S, Bonfield W. Carbonate Substitution in Precipitated Hydroxyapatite: an Investigation into the Effects of Reaction Temperature and Bicarbonate Ion Concentration. J. Biomed. Mater. Res., 41, 79-86, 1998

Barralet JE, Akao M, Aoki H, Aoki H. Dissolution of Dense Carbonate Apatite Subcutaneously Implanted in Wistar Rats, J. Biomed. Mater. Res., 49, 176-182 2000

Barralet JE, Best S, Bonfield W. Effect of Sintering Parameters on the Density and Microstructure of Carbonate Hydroxyapatite J. Mater. Sci:Mats. in Med., 11, 719-24, 2000

Barralet JE, Gibson IR, Knowles JK, Gaunt T, Wright AJ. Effect of Porosity Reduction on Compressive Strength and Microstructure of Calcium Phosphate Cement J.Biomed. Mater. Res., 63, 1-9 2002

Barralet JE, Aldred S, Wright AJ, Coombes AGA. In vitro behaviour of albumin loaded carbonate hydroxyapatite gels J. Biomed. Mater. Res. 60, 360-7, 2002

Barralet JE, Knowles JC, Best S, Bonfield W. Thermal decomposition of synthesized carbonate hydroxyapatite J. Mater. Sci:Mats in Med, 13, 529-533 2002

Barralet JE, Gibson IR, Grover LM, Gaunt T, Wright AJ. Preparation of Macroporous Calcium Phosphate Tissue Engineering Scaffold Biomaterials, 23 (15) 3063-3072, 2002.

Wang L, Shelton RM, Cooper PR, Lawson M, Triffitt JT, Barralet JE. Evaluation Of Sodium Alginate For Bone Marrow Cell Tissue Engineering Biomaterials, 24 (20) 3475 – 3481, 2003.

Gbureck U, Grolms O, Barralet JE, Grover LM, Thull R. Mechanical activation and setting reaction of ß-Tricalcium Phosphate Biomaterials 24 (23) 4123-31, 2003

Fleming GJP, Farooq AA, Barralet JE. The influence of powder/liquid mixing ratio on the performance of a glass-ionomer dental cement, Biomaterials 24 (23) 4173-9, 2003

Grover LM, Knowles JC, Barralet JE. In vitro dissolution of Brushite cement, Biomaterials 24 (23) 4133-41, 2003

Barralet JE, Wallace LL, Strain AJ. Tissue Engineering of Human Biliary Epithelial Cells on Polyglycolic Acid / Polycaprolactone Scaffolds Maintains Long-term Phenotypic Stability, Tissue Engineering 9 (5) 1037-1046 2003

Barralet JE, Fleming GJP, Campion C, Wright AJ, Harris J. Effect of furnace atmosphere on sintering behaviour of hydroxyapatite J. Mater. Sci. 38 (19) 3979-3993 2003

Barralet JE, Hofmann M, Grover LM, Gbureck U. High Strength Apatitic Cement by Modification with α-Hydroxy Acid Salts Adv. Mater. 15 (24), 2091-95, 2003.

Williams M, Downes S, Wallace WA, Rizzi S, Barralet JE, Coombes AGA. Precipitation casting of polycaprolactone for applications of tissue engineering and drug delivery Biomaterials 25 (2) 315-325 2004

Gbureck U, Barralet JE, Spatz K, Grover LM, Thull R. Ionic Modification of Calcium Phosphate Cement Viscosity Part I: Hypodermic injection and Strength Improvement of Apatite Cement Biomaterials 25 (11) 2187-2195 2004

Barralet JE, Gbureck U, Grover LM. Ionic Modification of Calcium Phosphate Cement Viscosity Part II: Hypodermic injection and Strength Improvement of Brushite Cement Biomaterials 25 (11) 2197-2203 2004

Gbureck U, Barralet JE, Hofmann M, Thull R. Mechanical Activation of Tetracalcium Phosphate J. Am. Ceram. Soc. 87 (2) 311–13 2004

Georgiou G, Knowles JC, Barralet JE. The Dynamic Shrinkage Behaviour of Hydroxyapatite and Glass-Reinforced Hydroxyapatites J Mater Sci Lett 39 2205-8 2004

Gbureck U, Barralet JE, Radu L, Klinger HG, Thull R. Amourphous alpha-tricalcium phosphate: Preparation and aqueous setting reaction J. Am. Ceram. Soc. 87 1126-32 2004

Georgiou G, Knowles JC, Barralet JE, Kong YM, Kim HE. The effect of hot pressing on the physical properties of glass reinforced hydroxyapatite J. Mater Sci.: Mats .in Med. 15 705 -10 2004

Gbureck U, Barralet JE, Hofmann M, Thull R. Nanocrystalline TTCP Cement J. Dent. Res. 83 425-8 2004

Perrie Y, Barralet JE, McNeil S, Vangala A. Liposome and noisome mediated delivery of DNA vaccines via the subcutaneous route. International Journal of Pharmaceutics 284, 31-41, 2004

Lawson M, Barralet JE,Wang L, Shelton RM, Triffitt JT. Adhesion and Growth of Bone Marrow Stromal Cells on Modified Alginate Hydrogels Tissue Engineering, 10, 1480-1491, 2004

Gbureck U, Dembski S, Thull R, Barralet JE. Solid State Reactions in Calcium Phosphate Cement Mixtures During Ageing, Biomaterials 26,3691-3697 2005

Gbureck U, Spatz K, Barralet JE , Thull R. Rheological enhancement of mechanically activated alpha-tricalcium phosphate cements J Biomed Mater Res 73B:1-6, 2005

Saleem IY, Vordermeier M, Barralet JE. AGA Coombes Improving peptide-based assays to differentiate between vaccination and M. bovis infection in cattle using nanoparticle carriers for adsorbed antigens. J. Contr. Rel. 102, 551-61, 2005

Barralet JE, Tremayne M, Lilley KJ, Gbureck U. Modification of calcium phosphate cement with α-hydroxy acids and their salts Chem. Mater. 17(6): 1313-1319, 2005

Duncan C.O., Shelton RM, Papini RPG, Balderson DS, Navsaria H, Barralet JE. In-vitro transfer of keratinocytes: comparison of transfer from fibrin membrane and delivery by aerosol spray J Biomed Mater Res, 73(2), 238-243, 2005

Barralet JE, Duncan C.O., Dover SM, Bassett DC, Nishikawa H, Monaghan A, Gbureck U. Cortical bone screw fixation in ionically modified apatite cements J Biomed Mater Res, 73(2), 221-228, 2005

Gbureck U, Dembski S, Thull R, Barralet JE. Thermal Analysis of Mechanically Activated TTCP, J. Am. Ceram. Soc, 88(5) 1327-1330, 2005.

Bohner M, Gbureck U, Barralet JE. Technological issues for the development of more efficient calcium phosphate bone cements: a critical assessment, Biomaterials 26(33) 6423-6429, 2005

Gbureck U, Knappe O, Grover LM, Barralet JE. Antimicrobial Potency of Alkali Ion Substituted Calcium Phosphate Cements Biomaterials, Biomaterials 26(34) 6880-6886, 2005

Jackson LE, Kariuki BM, Barralet JE, Wright AJ. Synthesis and structure γ-Ca(PO3)2; metaphosphate with unique criss-cross arrangement polyphosphate chains, Chem Mater 17(18); 4642, 2005

Grover LM, Gbureck U, Wright AJ, Barralet JE. Cement formulations in the calcium phosphate H2O-H3PO4-H4P2O7 system J. Am. Ceram. Soc. 88 (11) 3096-3103 2005

Gbureck U, Grübel S, Thull R, Barralet JE. Modified PMMA-cements for a hydrolysis resistant metal-polymer interface in orthopaedic applications. Acta Biomaterialia 6 (1) 671-676 2005

Grover LM, Gbureck U, Young AM, Wright AJ, Barralet JE. The effect of temperature on the setting and mechanical properties of an aqueous β-tricalcium phosphate – pyrophosphoric acid cement. J. Mater. Chem., 2005, 15, 4955 – 4962

LM Grover, U Gbureck, M Tremayne, A J Wright, J E Barralet, Biologically mediated resorption of brushite cement in vitro, Biomaterials, 27, (10) 2178-2185, 2006.

N.J.S. Gorst , Y. Perrie , U. Gbureck, A.L. Hutton, M.P. Hofmann, L.M. Grover, J.E. Barralet Effects of fibre reinforcement on the mechanical properties of brushite cement, Acta Biomaterialia 2, 95-102, (2006).

Fleming GJP, Kenny SM, Barralet JE The optimisation of the initial viscosity of an encapsulated glass-ionomer filling material following different mechanical mixing regimes. Journal of Dentistry 34 (2): 155-163 2006

R. M. Shelton; Y. Liu; P. R. Cooper; U. Gbureck; M.J. German; J. E Barralet, Bone Marrow Cell Gene Expression and Tissue Construct Assembly Using Octacalcium Phosphate Microscaffolds Biomaterials 27, 2874-2881, 2006

Xia Z, Grover LM, Huang Y, Adamopoulos I, Gbureck U, Triffit JT, Shelton RM, Barralet JE. In vitro Biodegradation of Three Brushite Calcium Phosphate Cements by a Macrophage Cell-line, Biomaterials. 27 (26) 2006, 4557-4565,

Hofmann MP, Young AM, Gbureck U, Barralet JE. FTIR monitoring of a fast setting brushite bone cement: Effect of intermediate phases, Journal of Materials Chemistry. 16 (31): 3199-3206 2006

M. P. Hofmann, S. N. Nazhat, U. Gbureck, J. E. Barralet, Real Time Monitoring of the Setting Reaction of Brushite-Forming Cement: Influence of Citric Acid Retardant Concentration and Powder-to-Liquid Ratio, J Biomed Mater Res. 79B (2): 360-364, 2006

Liu Y, Cooper PR, Barralet JE, Shelton RM. Influence of calcium phosphate crystal assemblies on the proliferation and osteogenic gene expression of rat bone marrow stromal cells. Biomaterials. 2007, 28(7):1393-403, 2006

U. Gbureck, T. Hölzel, C. Doillon, F. A. Müller, J.E. Barralet, Direct printing of bioceramic implants with spatially localised angiogenic factors, Adv. Mater 2007, 19, No. 6, 795-800.

K.J. Lilley, U. Gbureck, A.J. Wright, J.C. Knowles, D.F. Farrar and J.E. Barralet, Brushite Cements from Polyphosphoric Acid, Calcium Phosphate Systems, J. Am. Ceram. Soc. 2007, 90, 6: 1892-1898.

M.P. Hofmann, U. Gbureck, C.O. Duncan, M.S. Dover, J.E. Barralet, Carvable calcium phosphate bone substitute material, J Biomed Mater Res. 2007, 83B (1): 1-8.

U Gbureck, O Knappe, N Hofmann, J E. Barralet Antimicrobial Properties of Nanocrystalline Tetracalcium Phosphate Cements, J Biomed Mater Res. 2007, 83(1): 132-7.

U. Gbureck, E. Vorndran, F. A. Müller, J Barralet, Low temperature direct 3D printed bioceramics and biocomposites as drug release matrices, J. Contr Rel. 2007, 122(2): 173-180.

Frank A. Müller, U Gbureck, T Kasuga, J E. Barralet, U Lohbauer, Whisker-Reinforced Calcium Phosphate Cements, J Am Ceram Soc. 2007, 90(11): 3694-3697.

U. Gbureck, T. Hölzel, U. Klammert, K. Würzler, F. A. Müller, J. E. Barralet, Resorbable dicalcium phosphate bone substitutes made by 3D powder printing, Advanced Functional Materials 2007, 17, 3940-3945.

H Assaaoudi, Z Fang, JE Barralet, AJ Wright, IS Butler, JA Kozinski, Synthesis, characterization and properties of erbium-based nanofibres and nanorods, Nanotechnology, 2007, 18 (44): 1-7.

P. Habibovic, U. Gbureck, C. J. Doillon, D. C. Bassett, C. A. van Blitterswijk and J. E. Barralet, Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants, Biomaterials 2008, 29(7): 944-953


A M. Young, P Y J. Nga, U Gbureck, S N. Nazhat, J E, Barralet, M P. Hofmann Characterisation of chlorhexidine – releasing, fast setting, brushite bone cements Acta Biomaterialia 2008


S. Akhtar, J.E. Barralet, D.Farrar and A.J.Wright , Influence of Phosphate Ions on the Stability of Amorphous Calcium Carbonate Key Engineering Materials 309-311 179-82 2006

LM Grover, S Patel, Y Hu, U Gbureck, JE Barralet, Modifying Brushite Cement Degradation Using Calcium Alginate Beads, Key Engineering Materials, 2008, Vols. 361-363: 311-314.

Y Liu, J Barralet, P Cooper, R Shelton, Effects of Octacalcium Phosphate on the Development of Bone Marrow Derived Stromal Cells: Comparison of Osteogenic Medium/OCP Induced Osteocalcin Expression, Key Engineering Materials, 2008, Vols. 361-363: 2009-1012.

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