Simon Grandjean Lapierre

Simon Grandjean Lapierre, MD, M.Sc., FRCPC

Associate Professor in the Microbiology, Infectious Diseases and Immunology Department of Université de Montréal

Clinical-investigator position at the Montreal University Hospital Research Center (CRCHUM)

Visiting researcher at Institut Pasteur de Madagascar

Telephone :   514 890-8000 # 20935

simon.grandjean.lapierre [at]



Tuberculosis Care and Research

Simon Grandjean Lapierre completed an MD at Université de Sherbrooke and residency training in Internal Medicine, Infectious Diseases ,and Medical Microbiology at Université de Montréal. He also completed an MSc in molecular diagnostics applied to mycobacteria at Université Aix-Marseille. He subsequently did his post-doctoral training in Madagascar on the use of emerging technologies in global health and sequencing-based TB diagnostics. He is presently a clinical investigator at the Montreal University Hospital Research Centre (CRCHUM) and an Associate Professor in the Université de Montréal's Department of Microbiology, Infectious Diseases, and Immunology.


Simon Grandjean Lapierre directs a translational research program focused  on the impact of molecular epidemiology on TB control in  high-burden settings and new technologies, including digital cough monitoring for screening and clinical monitoring of TB disease. His research is supported by the Fonds de Recherche Santé Québec, the Canadian Institutes for Health Research and the Bill and Melinda Gates Foundation.


Molecular epidemiology

Acoustic epidemiology

Innovative technologies & public health

Selected Publications



Complexities and benefits of adopting next-generation sequencing-based tuberculosis diagnostics: a qualitative study among stakeholders in low and high-income countries.

Grandjean Lapierre S, Nouvet E, Boutin CA, Rabodoarivelo MS, Mahboob O, Smith MJ, Rakotosamimanana N. BMJ Open. 2023 Apr 10;13(4):e066651. doi: 10.1136/bmjopen-2022-066651.PMID: 37037623


On-demand, hospital-based, severe acute respiratory coronavirus virus 2 (SARS-CoV-2) genomic epidemiology to support nosocomial outbreak investigations: A prospective molecular epidemiology study.

Benoit P, Jolicoeur G, Point F, Soucy C, Normand K, Morency-Potvin P, Gagnon S, Kaufmann DE, Tremblay C, Coutlée F, Harrigan PR, Hardy I, Smith M, Savard P, Grandjean Lapierre S. Antimicrob Steward Healthc Epidemiol. 2023 Mar 8;3(1):e45. doi: 10.1017/ash.2023.119. eCollection 2023.PMID: 36960087


Evaluation of Nanopore sequencing for Mycobacterium tuberculosis drug susceptibility testing and outbreak investigation: a genomic analysis.

Hall MB, Rabodoarivelo MS, Koch A, Dippenaar A, George S, Grobbelaar M, Warren R, Walker TM, Cox H, Gagneux S, Crook D, Peto T, Rakotosamimanana N, Grandjean Lapierre S, Iqbal Z. Lancet Microbe. 2023 Feb;4(2):e84-e92. doi: 10.1016/S2666-5247(22)00301-9. Epub 2022 Dec 19.PMID: 36549315 


The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis.

Walker TM, Miotto P, Köser CU, Fowler PW, Knaggs J, Iqbal Z, Hunt M, Chindelevitch L, Farhat M, Cirillo DM, Comas I, Posey J, Omar SV, Peto TE, Suresh A, Uplekar S, Laurent S, Colman RE, Nathanson CM, Zignol M, Walker AS; CRyPTIC Consortium; Seq&Treat Consortium; Crook DW, Ismail N, Rodwell TC. Lancet Microbe. 2022 Apr;3(4):e265-e273. doi: 10.1016/S2666-5247(21)00301-3.PMID: 35373160 


Making cough count in tuberculosis care.

Zimmer AJ, Ugarte-Gil C, Pathri R, Dewan P, Jaganath D, Cattamanchi A, Pai M, Grandjean Lapierre S. Commun Med (Lond). 2022 Jul 6;2:83. doi: 10.1038/s43856-022-00149-w. eCollection 2022.PMID: 35814294 


Digital cough monitoring - A potential predictive acoustic biomarker of clinical outcomes in hospitalized COVID-19 patients.

Altshuler E, Tannir B, Jolicoeur G, Rudd M, Saleem C, Cherabuddi K, Doré DH, Nagarsheth P, Brew J, Small PM, Glenn Morris J, Grandjean Lapierre S. J Biomed Inform. 2023 Feb;138:104283. doi: 10.1016/j.jbi.2023.104283. Epub 2023 Jan 9.PMID: 36632859 


Acoustic surveillance of cough for detecting respiratory disease using artificial intelligence.

Gabaldón-Figueira JC, Keen E, Giménez G, Orrillo V, Blavia I, Doré DH, Armendáriz N, Chaccour J, Fernandez-Montero A, Bartolomé J, Umashankar N, Small P, Grandjean Lapierre S, Chaccour C. ERJ Open Res. 2022 May 30;8(2):00053-2022. doi: 10.1183/23120541.00053-2022. eCollection 2022 Apr.PMID: 35651361

External Links


Twitter @SimonGLapierre 


LinkedIn @Simon Grandjean Lapierre


« Les drones participent à la lutte contre la tuberculose »


« A lemur died from tuberculosis – a likely victim of the flourishing illegal pet trade”


“AI cough-monitoring can change the way we diagnose disease”




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