Dr. Erwin Schurr
(514) 934-1934 x44513
We are studying the genetic factors that predispose to tuberculosis and leprosy, two important mycobacterial infections that affect and kill an estimated three million people each year. In particular, the only effective and workable approach to break the transmission cycle of tuberculosis is the availability of a universally efficacious vaccine. Hence, we are working on the identification of host gene variants that determine the protective efficacy of present and newly developed tuberculosis vaccines. To accomplish our scientific objectives, we are collaborating closely with several research groups in the developing world and maintain several field sites for the genetic epidemiological analysis of tuberculosis and leprosy.
Tuberculosis, leprosy, human genetics
Cobat, A., C.J. Gallant, L. Simkin, G.F. Black, K. Stanley, J. Hughes, T.M. Doherty, W.A. Hanekom, B. Eley, N. Beyers, J.P. Jaïs, P. van Helden, L. Abel , E.G. Hoal, J.L. Casanova, E. Schurr, A. Alcaïs “Two loci control tuberculin skin test reactivity in a hyper-endemic region of tuberculosis” J Exp Med 206:2583-2591, 2009
M. Orlova, A. Cobat, N.T. Huong, N.N. Ba, N.V. Thuc, J Spencer, Y. Nédélec, L. Barreiro V.H. Thai, L. Abel, A. Alcais, E. Schurr “Gene set signature of reversal reaction type I in leprosy patients” PLoS Genetics, 9: e1003624;2013.
A. Cobat, E.G. Hoal, C.J. Gallant, L. Simkin, G.F. Black, K. Stanley, J.P. Jaïs, T.H. Yu, A. Boland-Auge, G. Grange, C. Delacourt, P. van Helden, J.L. Casanova, L. Abel, A. Alcaïs and E. Schurr “Identification of a major locus, TNF1, that controls BCG-triggered TNF production by leukocytes in an area hyperendemic for tuberculosis” Clin Infect Dis 57:963-970, 2013