Richard Kremer

Richard Kremer, MD, Ph.D.

Professor of Medicine, Department of Medicine


Director, Bone and Mineral Unit
Co-Director, Musculoskeletal Axis
Academic Director, McGill Division of Medical Biochemistry
Centre for Bone and Periodontal Research
McGill University Health Centre, 1001 Decarie Blvd., Montreal, QC H4A 3J1

Tel: 514 934-1934 ext. 35698

richard.kremer [at] mcgill.ca

Biographical Sketch

Dr. Richard Kremer is currently Professor and Director of the Bone and Mineral Unit in the Department of Medicine of McGill University.  He is also the co-leader of the Musculoskeletal Axis of the McGill University Health Centre.  Born in Paris, Dr Kremer received his MD (1977) and Ph.D. (1979) degrees at the Pierre et Marie Curie University of Paris, and completed his internal medicine and endocrinology residency at La Pitié-Salpêtrière Hospital in Paris.  He then moved to Canada and completed his residency training at the Montreal General Hospital, Royal Victoria and Ottawa Civic Hospitals.  He pursued his research training at the Royal Victoria Hospital and joined the Division of Endocrinology as a full-time physician-scientist in 1989.

Dr. Kremer is the recipient of several prizes and awards including the Chercheur National award from the Fonds de Recherches en Santé du Québec.  He has made significant contributions to the Canadian Institutes of Health Research (CIHR), the US National Institutes of Health (NIH) and the US National Cancer Research Institute (NCI) on grant and award committees.  He is a reviewer and sits on the Editorial Board for several international journals and is a consultant to industry, academic and lay organizations in his capacity as a clinician scientist and expert in metabolic bone diseases.

Keywords

Vitamin D, PTHrP, osteoporosis, bone strength, animal models, breast cancer, circulating tumor cells, translational research, clinical trials, skeletal metastasis

Research or Clinical Activities

Over the past 20 years research in my laboratory has focused on the role of calcium regulating hormones in health and disease. First, my laboratory is trying to elucidate how 1, 25-dihydroxyvitamin D3 1, 25(OH) 2D3, the active form of vitamin D, influences cell growth and differentiation in the skeleton and in cancer cells. An extension of these studies is to elaborate new therapeutic strategies with vitamin D derivatives in osteoporosis and in cancer. For this purpose we developed animal models to study the efficacy of vitamin D and its analogs in models of osteoporosis and cancer. In collaboration with colleagues in Australia and in the US we discovered that a lack of vitamin D results in fat accumulation in bone and muscle with deleterious consequences for the musculoskeletal system. We also reported that a lack of vitamin D leads to accelerated development of breast cancer. Another major focus of our  research activities has been to establish the role of parathyroid hormone related protein (PTHrP) in tumor initiation, growth and metastasis This has led to the development of a novel targeted therapy against breast cancer using monoclonal antibodies raised against PTHrP. Finally, a recent focus of our research activities has been to elucidate the role of circulating tumor cells in breast cancer progression in view of identifying specific markers of skeletal metastasis in breast and prostate cancer. The goal of these studies is to develop targeted therapies in cancer based on the unique profile of cancer cells that are refractory to most chemotherapeutic interventions.

Selected Recent Publications

Kremer R, Gagnon B, Meguerditchian AN, Nadeau L,  Mayo N. Effects of oral bisphosphonates for osteoporosis on development of skeletal metastases in women with breast cancer: Results from a pharmaco-epidemiological study. J. Natl Cancer Inst. 106(11),2014.

Huang DC, Yang XF, Camirand A, Kremer R. Suppression of parathyroid hormone-related peptide in a female mouse xenograft model identifies a novel therapeutic target against melanoma. Endocrinology 155(10):3739-49,2014 .

Li J, Karaplis AC, Huang DC, Siegel PM, Camirand A, Yang XF, Muller WJ, Kremer R. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target J Clin Invest. 121(12):4655-69, 2011

Gilsanz V, Kremer A, Mo AO, Wren TA, Kremer R. Vitamin D status and its relation to muscle mass and muscle fat in young women.J Clin Endocrinol Metab 95(4):1595-1601, 2010

Gustavo Duque, Dao Chao Huang, Michael Macoritto, Daniel Rivas, Xian Fang Yang, Richard Kremer. Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis. Stem Cells 27(3):550-558, 2009

PubMed Publications – R. Kremer