 |
Andrew Bateman, Ph.D. Professor, Department of Medicine, McGill University Tel: 514-934-1934 ext. 35833 andrew.bateman [at] muhc.mcgill.ca |
Biographical Sketch
Education
B.Sc. Imperial College of Science and Technology, University of London, (U.K.) Biochemistry 1981
Graduate Ph.D. Imperial College of Science and Technology, University of London, (U.K.) Biochemistry
Supervisor Professor, Anne Dell, 1985
Thesis topic: Fast Atom Bombardment Mass Spectrometry in the Study of Naturally Occurring Peptides
Post-graduate training
1985-1990 Postdoctoral Fellow, Endocrine Research Laboratory, Royal Victoria Hospital and McGill University (Supervisor Professor Samuel Solomon)
Research project: Post-Translational Modification of Pituitary Peptides
University Appointments
1991-96 Assistant Professor, Medicine, McGill, University
1996-2005 Associate Professor, Medicine, McGill University
2005 to present Full Professor, Medicine, McGill University
Keywords
Progranulin, neuroprotection, wound repair, growth factors, cell communication, cancer progression
Research or Clinical Activities
I study communication between cells and its relationship to disease. Progranulin is a protein that is secreted by cells and instructs nearby cells to divide and to move. It also inhibits cell death caused by challenges such as starvation or chemotherapeutic drugs. There are many important roles for this molecule.
It is over expressed in many cancers and renders cancer cells much more aggressive. Blocking progranulin may be a route to cancer therapy.
Progranulin keeps nerve cells alive. Losing only one half of the brain’s progranulin levels by mutation causes frontotemporal dementia, a devastating degenerative brain disease. I wish to understand how progranulin protects the brain.
Progranulin reduces inflammation. Its levels increase rapidly in injured tissues. We have shown that progranulin helps the wound repair process. This may help diabetics and others with chronic wounds that fail to heal properly.
Selected Recent Publications
Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease
By: Chitramuthu, Babykumari P.; Bennett, Hugh P. J.; Bateman, Andrew
BRAIN (2017) Volume: 140 Pages: 3081-3104
Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS
By: Chitramuthu, Babykumari P.; Kay, Denis G.; Bateman, Andrew; et al.
PLOS ONE (2017) Volume: 12 Article Number: e017478
The Evolution of the Secreted Regulatory Protein Progranulin
By: Palfree, Roger G. E.; Bennett, Hugh P. J.; Bateman, Andrew
PLOS ONE (2015) Volume: 10 Article Number: e0133749
Expression of the Growth Factor Progranulin in Endothelial Cells Influences Growth and Development of Blood Vessels: A Novel Mouse Model
By: Toh, Huishi; Cao, Mingju; Daniels, Eugene; et al.
PLOS ONE (2013) Volume: 8 Article Number: e64989
Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models
Tauffenberger, Arnaud; Chitramuthu, Babykumari P.; Bateman, Andrew; et al.
HUMAN MOLECULAR GENETICS (2013) Volume: 22 Pages: 782-794