Andrew Bateman, Ph.D.
Professor, Department of Medicine, McGill University
Tel: 514-934-1934 ext. 35833
andrew.bateman [at] mcgill.ca
B.Sc. Imperial College of Science and Technology, University of London, (U.K.) Biochemistry 1981
Graduate Ph.D. Imperial College of Science and Technology, University of London, (U.K.) Biochemistry
Supervisor Professor, Anne Dell, 1985
Thesis topic: Fast Atom Bombardment Mass Spectrometry in the Study of Naturally Occurring Peptides
1985-1990 Postdoctoral Fellow, Endocrine Research Laboratory, Royal Victoria Hospital and McGill University (Supervisor Professor Samuel Solomon)
Research project: Post-Translational Modification of Pituitary Peptides
1991-96 Assistant Professor, Medicine, McGill, University
1996-2005 Associate Professor, Medicine, McGill University
2005 to present Full Professor, Medicine, McGill University
Progranulin, neuroprotection, wound repair, growth factors, cell communication, cancer progression
Research or Clinical Activities
I study communication between cells and its relationship to disease. Progranulin is a protein that is secreted by cells and instructs nearby cells to divide and to move. It also inhibits cell death caused by challenges such as starvation or chemotherapeutic drugs and regulates lysosomal activity. There are many important roles for this molecule.
In animal models progranulin greatly slows, and even stops, the onset of neurodegenerative diseases, while in patients, heterozygous nonsense mutation of the progranulin gene causes frontotemporal dementia. I wish to understand how progranulin protects the brain and how this can be used to develop new neuroprotective therapies.
Progranulin reduces inflammation. Its levels increase rapidly in injured tissues. We have shown that progranulin helps wound repair and may have very useful activities for regenerative medicine. Progranulin is over expressed in many cancers and renders cancer cells more aggressive. Blocking progranulin may be a route to cancer therapy.
Selected Recent Publications
Multiple Molecular Pathways Are Influenced by Progranulin in a Neuronal Cell Model-A Parallel Omics Approach.
By: Chitramuthu Babykumari P, Campos-García Victor R, Bateman Andrew.
FRONT. NEUROSCIENCE (2022) Volume 15: Article Number: 775391.
Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.
By: Doyle James J, Maios Claudia, Vrancx Celine, Duhaime Sarah, Chitramuthu Babykumari P, Bennett Hugh PJ, Bateman A, Parker JA.
Proc Natl Acad Sci U S A. (2021) Volume:118 Article Number: e2022115118.
Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease
By: Chitramuthu, Babykumari P.; Bennett, Hugh P. J.; Bateman, Andrew
BRAIN (2017) Volume: 140 Pages: 3081-3104
The Evolution of the Secreted Regulatory Protein Progranulin
By: Palfree, Roger G. E.; Bennett, Hugh P. J.; Bateman, Andrew
PLOS ONE (2015) Volume: 10 Article Number: e0133749
Expression of the Growth Factor Progranulin in Endothelial Cells Influences Growth and Development of Blood Vessels: A Novel Mouse Model
By: Toh, Huishi; Cao, Mingju; Daniels, Eugene; Bateman Andrew.
PLOS ONE (2013) Volume: 8 Article Number: e64989