Andrew Bateman

 

 

Andrew Bateman, Ph.D.

Professor, Department of Medicine, McGill University
Research Institute of the McGill University Health Centre
Room EM2.3226, 1001 Decarie Blvd.
Montreal, QC, H4A 3J1 

Tel: 514-934-1934 ext. 35833

andrew.bateman [at] muhc.mcgill.ca

Biographical Sketch

Education
B.Sc.  Imperial College of Science and Technology, University of London, (U.K.) Biochemistry 1981
Graduate  Ph.D.  Imperial College of Science and Technology, University of London, (U.K.) Biochemistry
Supervisor Professor, Anne Dell, 1985
Thesis topic: Fast Atom Bombardment Mass Spectrometry in the Study of Naturally Occurring Peptides

Post-graduate training
1985-1990   Postdoctoral Fellow, Endocrine Research Laboratory, Royal Victoria Hospital and McGill University (Supervisor Professor Samuel Solomon)
Research project: Post-Translational Modification of Pituitary Peptides

University Appointments
1991-96   Assistant Professor, Medicine, McGill, University
1996-2005   Associate Professor, Medicine, McGill University
2005 to present   Full Professor, Medicine, McGill University

Keywords

Progranulin, neuroprotection, wound repair, growth factors, cell communication, cancer progression

Research or Clinical Activities

I study communication between cells and its relationship to disease. Progranulin is a protein that is secreted by cells and instructs nearby cells to divide and to move. It also inhibits cell death caused by challenges such as starvation or chemotherapeutic drugs. There are many important roles for this molecule.

It is over expressed in many cancers and renders cancer cells much more aggressive. Blocking progranulin may be a route to cancer therapy.

Progranulin keeps nerve cells alive. Losing only one half of the brain’s progranulin levels by mutation causes frontotemporal dementia, a devastating degenerative brain disease. I wish to understand how progranulin protects the brain. 

Progranulin reduces inflammation. Its levels increase rapidly in injured tissues. We have shown that progranulin helps the wound repair process. This may help diabetics and others with chronic wounds that fail to heal properly.

Selected Recent Publications

Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease 
By: Chitramuthu, Babykumari P.; Bennett, Hugh P. J.; Bateman, Andrew
BRAIN   (2017) Volume: 140   Pages: 3081-3104  
 
Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS 
By: Chitramuthu, Babykumari P.; Kay, Denis G.; Bateman, Andrew; et al.
PLOS ONE   (2017) Volume: 12    Article Number: e017478
 
The Evolution of the Secreted Regulatory Protein Progranulin 
By: Palfree, Roger G. E.; Bennett, Hugh P. J.; Bateman, Andrew
PLOS ONE   (2015) Volume: 10    Article Number: e0133749 
 
Expression of the Growth Factor Progranulin in Endothelial Cells Influences Growth and Development of Blood Vessels: A Novel Mouse Model 
By: Toh, Huishi; Cao, Mingju; Daniels, Eugene; et al.
PLOS ONE   (2013) Volume: 8    Article Number: e64989
 
Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models 
Tauffenberger, Arnaud; Chitramuthu, Babykumari P.; Bateman, Andrew; et al.
HUMAN MOLECULAR GENETICS   (2013) Volume: 22    Pages: 782-794

PubMed Publications (partial) – A. Bateman