|Geoffrey N. Hendy, Ph.D.
Professor, Department of Medicine
It is with great sadness that I must announce that Dr Geoffrey N Hendy, after a bout with cancer, passed away on Thursday August 9, 2018. Dr Hendy obtained his PhD in England in the laboratory of Dr Jeffrey L.H. O'Riordan at the Middlesex Hospital in London. He subsequently did postdoctoral training at Harvard and MIT before being recruited to the Calcium Laboratory of the Division of Endocrinology in the Department of Medicine at McGill in 1985. His laboratory studied the molecular genetics of mineral metabolism disorders with a focus on functional analysis of inherited mutations in genes controlling calcium and skeletal homeostasis, and particularly genes encoding the calcium-sensing receptor, and menin (the Multiple Endocrine Neoplasia type 1 gene product). He was a very devoted scientist, with many outstanding contributions and an exemplary international reputation in his field. In addition, he was highly active as an educator at McGill, teaching and mentoring students in the Departments of Human Genetics and Medicine and was a popular choice for undergraduate students when first choosing a laboratory for their practicum. Dr Hendy also served as a mentor to numerous graduate students and started them on successful research careers, as well as serving as an Academic Advisor for many others. Postdoctoral fellows and colleagues also benefitted enormously from his knowledge and skills as a scientist. He will be missed by all.
-Dr. David Goltzman
My laboratory studies the molecular genetics of mineral metabolism disorders with a focus on functional analysis of inherited mutations in genes controlling calcium and skeletal homeostasis.
Calcium, Molecular Genetics, Calcium-sensing Receptor, Menin, Mouse Models
Research or Clinical Activities
Research foci: Calcium-sensing Receptor, Menin (the Multiple Endocrine Neoplasia type 1 gene product)
Selected Recent Publications
Puzhko, S., Goodyer, C.G., Kerachian, M.A., Canaff, L., Misra, M., Jüppner, H., Bastepe, M., Hendy, G.N. Parathyroid hormone signaling via Gαs is selectively inhibited by an NH2-terminally truncated Gαs: implications for pseudohypoparathyroidism. J. Bone Miner. Res. 26:2473-2485, 2011.
Canaff, L., Vanbellinghen, J-F., Kanazawa, I., Kwak, H., Garfield, N., Vautour, L., Hendy, G.N. Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA. J. Clin. Endocrinol. Metab. 97:E282-E291, 2012.
Canaff, L., Vanbellinghen, J-F., Kaji, H., Goltzman, D., Hendy, G.N. Impaired transforming growth factor-beta (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with Multiple Endocrine Neoplasia type 1 (MEN1). J. Biol. Chem. 287:8584-8597, 2012.
Hendy, G.N., Canaff, L., Cole, D.E.C. The CASR gene: Alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: Structure and ligand binding sites. Best Pract Res Clin Endocrinol Metab 27: 285-301, 2013.
Hendy, G.N., Cole, D.E.C. Invited Editorial. Ruling in a suspect: the role of AP2S1 mutations in familial hypocalciuric hypercalcemia type 3. J. Clin. Endocrinol. Metab. In press. 2013.