Daniel J. Bernard, Ph.D.
Professor, Department of Pharmacology and Therapeutics
daniel.bernard [at] mcgill.ca
Prof. Bernard earned his Ph.D. at Johns Hopkins University and then conducted post-doctoral research in molecular endocrinology at Northwestern University. His first independent position was as a Staff Scientist at the Population Council’s Center for Biomedical Research at The Rockefeller University. He then moved his lab to McGill in April 2006.
Pituitary, neuroendocrinology, reproductive biology, signal transduction, transcription, mouse genetics, cell culture
Research or Clinical Activities
The Bernard lab investigates molecular mechanisms of pituitary hormone synthesis and action using in vitro and in vivo approaches. Projects in the lab concern: 1) signal transduction mechanisms through which members of the transforming growth factor β superfamily regulate pituitary follicle-stimulating hormone (FSH) synthesis, 2) mechanisms of gonadotropin-releasing hormone (GnRH) signaling in pituitary gonadotrope cells, 3) extragonadal actions of FSH, and 4) hypothalamic-pituitary control of thyroid hormone production.
Selected Recent Publications
Sun Y, Bak B, Schoenmakers N, van Trotsenburg AS, Oostdijk W, Voshol P, Cambridge E, White JK, le Tissier P, Gharavy SN, Martinez-Barbera JP, Stokvis-Brantsma WH, Vulsma T, Kempers MJ, Persani L, Campi I, Bonomi M, Beck-Peccoz P, Zhu H, Davis TM, Hokken-Koelega AC, Del Blanco DG, Rangasami JJ, Ruivenkamp CA, Laros JF, Kriek M, Kant SG, Bosch CA, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GC, Pereira AM, Dunnen JT, Wade MG, Breuning MH, Hennekam RC, Chatterjee K, Dattani MT, Wit JM, Bernard DJ (2012) Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nature Genetics 44(12):1375-1381.
Toufaily C, Fortin J, Alonso CAI, Lapointe E, Zhou X, Santiago-Andres Y, Lin Y-F, Cui Y, Wang Y, Devost D, Roelfsema F, Steyn F, Hanyaloglu AC, Hébert TE, Fiordelisio T, Boerboom D, Bernard DJ (2021) Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice. eLife, 10:e72937.
Ruf-Zamojski F, Zhang Z, Zamojski, Smith GR, Mendelev N, Liu H, Nudelman G, Moriwaki M, Pincas H, Castanon RG, Nair VD, Seenarine N, Amper MAS, Zhou X, Ongaro L, Toufaily C, Schang G, Nery JR, Bartlett A, Aldridge A, Jain N, Childs GV, Troyanskaya OG, Ecker JR, Turgeon JL, Welt CK, Bernard DJ, Sealfon SC (2021) Single nucleus multi-omics regulator atlas of the murine pituitary. Nature Communications 12: 2677.
Brûlé E, Wang Y, Li Y, Lin Y-F, Zhou X, Ongaro L, Alonso CAI, Buddle ERS, Schneyer AL, Byeon C-H, Hinck CS, Mendelev N, Russell JP, Cowan M, Boehm U, Ruf-Zamojski F, Zamojski M, Andoniadou CL, Sealfon SC, Harrison CA, Walton KL, Hinck AP, Bernard DJ (2021) TGFBR3L is an inhibin B co-receptor that regulates female fertility. Science Advances 7(51): eabl4391.