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Daniel J. Bernard, Ph.D. Professor, Department of Pharmacology and Therapeutics Tel: 514-398-2525 daniel.bernard [at] mcgill.ca
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Biographical Sketch
Prof. Bernard earned his Ph.D. at Johns Hopkins University and then conducted post-doctoral research in molecular endocrinology at Northwestern University. His first independent position was as a Staff Scientist at the Population Council’s Center for Biomedical Research at The Rockefeller University. He then moved his lab to McGill in April 2006.
Keywords
Pituitary, neuroendocrinology, reproductive biology, signal transduction, transcription, mouse genetics, cell culture
Research or Clinical Activities
The Bernard lab investigates molecular mechanisms of pituitary hormone synthesis using in vitro and in vivo approaches. Projects in the lab concern: 1) signal transduction mechanisms through which members of the transforming growth factor β superfamily regulate pituitary follicle-stimulating hormone (FSH) synthesis, 2) mechanisms of gonadotropin-releasing hormone (GnRH) signaling in pituitary gonadotrope cells, and 3) hypothalamic-pituitary control of thyroid hormone production.
Selected Recent Publications
Li Y, Schang G, Boehm U, Deng CX, Graff J, Bernard DJ (2017) SMAD3 regulates follicle-stimulating hormone (FSH) synthesis by pituitary gonadotrope cells in vivo. Journal of Biological Chemistry 292(6):2301-2314.
Turgeon M-O, Silander TL, Doycheva D, Liao X-H, Rigden M, Ongaro L, Zhou X, Joustra SD, Wit JM, Wade MG, Heuer H, Refetoff S,Bernard DJ (2017) TRH action is impaired in pituitaries of male IGSF1-deficient mice. Endocrinology 158 (4): 815-830.
Fortin J, Deng C-X, Boehm U, Bernard DJ (2014) Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. FASEB J 28(8):3396-3410.
Sun Y, Bak B, Schoenmakers N, van Trotsenburg AS, Oostdijk W, Voshol P, Cambridge E, White JK, le Tissier P, Gharavy SN, Martinez-Barbera JP, Stokvis-Brantsma WH, Vulsma T, Kempers MJ, Persani L, Campi I, Bonomi M, Beck-Peccoz P, Zhu H, Davis TM, Hokken-Koelega AC, Del Blanco DG, Rangasami JJ, Ruivenkamp CA, Laros JF, Kriek M, Kant SG, Bosch CA, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GC, Pereira AM, Dunnen JT, Wade MG, Breuning MH, Hennekam RC, Chatterjee K, Dattani MT, Wit JM, Bernard DJ (2012) Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nature Genetics 44(12):1375-1381.