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Killam Seminar Series: The Disappearing Act: How Microglia Influence Myelin Health Across the Lifespan

Mardi, 7 mai, 2024 16:00à17:00
Montreal Neurological Institute de Grandpre Communications Centre, 3801 rue University, Montreal, QC, H3A 2B4, CA

Grâce à la générosité des fiducies Killam, Le Neuro convoque lors d’une série de séminaires des conférenciers d’exception dont les travaux passionnent ses chercheurs et ceux de l’Université McGill. 


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Veronique Miron, PhD

Chaire John David Eaton, recherche sur la sclérose en plaques, Keenan Research Centre for Biomedical Research, St. Michael's Hospital, Canada

Professeure, Département d'immunologie, Université de Toronto, Canada

Hôte: rami.massie [at] mcgill.ca (R)roberta.lapiana [at] mcgill.ca (oberta La Piana)

Abstract: Myelin is the insulation surrounding axons, which is critical for central nervous system health and function, yet it is damaged in common neurological conditions such as multiple sclerosis (MS) and pathological aging. Although myelin can be regenerated in the form of remyelination, the efficiency of this process decreases with aging and the progression of MS. Our lab has discovered that glial interactions are critical in maintaining myelin health and regulating remyelination post-injury. For instance, we have seen that the absence of microglia is sufficient to initiate spontaneous demyelination. In addition, we have identified surprising mechanisms by which microglia support CNS remyelination. Here, I will present our latest work understanding how microglia influence oligodendrocyte heterogeneity and the dynamics of myelin damage and repair. This has important implications for devising novel therapeutic strategies to support myelin health in aging and disease.

Le Neuro McGillMcGill University Health CentreKillam Laureates

 

Le Neuro (L'Institut-hôpital neurologique de Montréal) - un institut de recherche et d’enseignement bilingue de McGill, qui offre des soins de haut calibre aux patients - est la pierre angulaire de la Mission en neurosciences du Centre universitaire de santé McGill. Nous sommes fiers d’être une institution Killam, soutenue par les fiducies Killam.

 

 

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