Major depressive disorder (MDD) is a psychiatric disorder linked to heightened suicide risk, yet underlying biological mechanisms remain poorly understood. Atypical brain asymmetries relative to population-level have been implicated in MDD, particularly in functional and structural studies; however, molecular-level hemispheric differences have been less explored. To address this gap, we examined cell-type specific gene expression patterns in the subgenual anterior cingulate cortex (sgACC), a region involved in emotion, cognition, and strongly implicated in MDD.