Yu Xia

Academic title(s): 

Canada Research Chair in Computational and Systems Biology

Yu Xia
Contact Information

Macdonald Engineering Building, Room 389

Email address: 
brandon.xia [at] mcgill.ca
Department of Bioengineering

Ph.D. Stanford University
B.S. Peking University


BIEN 310: Introduction to Biomolecular Engineering (3 credits)
BIEN 410: Computational Methods in Biomolecular Engineering (3 Credits)

Research areas: 
Computational Biology
Selected publications: 

Structural principles within the human-virus protein-protein interaction network.
Franzosa EA, Xia Y. 
Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).

Structural determinants of protein evolution are context-sensitive at the residue level.
Franzosa EA, Xia Y. 
Mol. Biol. Evol. 26: 2387-2395 (2009).

Relating three-dimensional structures to protein networks provides evolutionary insights. 
Kim PM, Lu LJ, Xia Y, Gerstein MB. 
Science 314: 1938-1941 (2006).

Visit MEDLINE indexed publications and the following list for more.

Areas of interest: 
  • Construction of genome-scale computer models of biomolecular networks with high spatial and temporal resolutions.
  • Use of genome-scale models to probe the biophysical and engineering principles of biological networks.
  • Use of genome-scale models to study the systems biology of diseases
  • Computational Structural Biology. Prediction and analysis of protein structure and function; evolutionary and design principles of proteins
  • Computational Systems Biology. Prediction and analysis of protein networks; evolutionary and design principles of protein networks.
  • Bioinformatics. Development and application of bioinformatics algorithms to analyze biological sequence, structural and functional data.
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