Thomas Ming Swi Chang

Academic title(s): 

Professor Department of Biomedical Engineering
Professor Department of Physiology  

Thomas Ming Swi Chang
Contact Information

Artificial Cells and Organs Research Centre
McIntyre Medical Sciences Building
3655 Promenade Sir William Osler, Room 1004
Montréal, QC  H3G 1Y6

Email address: 
thomas.chang [at]
Research areas: 
Molecules & Materials
Living Systems Engineering
Areas of expertise: 

Chang is credited with inventing microencapsulation, the technique that enables functional biochemical to be held inside artificial membranes so they can emulate both in-vitro and in-vivo the behaviour of some natural cells. "Artificial cells" already have many medical applications.They are used in cases of chronic renal failure, drug poisoning, liver failure, enzyme therapy and metabolic function replacement. 

Chang's group is working with artificial cells filled with enzymes. They convert waste products such as ammonia and urea into the essntial amino acids valine, leucine and isoleucine which also hold promise as a treatment of enzyme-deficiency diseases such as phenylketonuria (PKU) that could process the damaging phenylalanine and remove it from the system. 


Artificial Cells
Blood Substitutes
Drug Delivery
Enzyme Engineering

Selected publications: 
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