Darcy Wagner

Academic title(s): 

Professor, Department of Biomedical Engineering

Professor, Department of Medicine, Division of Experimental Medicine

Canada Excellence Research Chair in Lung Regenerative Medicine 

Faculty, Meakins-Christie Laboratories (Meakins)

Scientist, Translational Research in Respiratory Diseases Program (RESP) at the Research Institute of the McGill University Health Centre (RI-MUHC)

Principal Investigator, McGill Regenerative Medicine Network (MRM Network

Darcy Wagner
Contact Information

Research Institute of the McGill University Health Centre

1001 Décarie Blvd., Block E, Montreal, QC, CANADA H4A 3J1

514 934-1934 x76172
Email address: 
darcy.wagner [at] mcgill.ca
Areas of expertise: 

Our lab focuses on how the extracellular environment directs stem cell behavior for endogenous and exogenous lung tissue regeneration. We use a multidisciplinary approach using advances in materials science (polymer design and synthesis), manufacturing (e.g. 3D bioprinting), and endogenous and iPSC-derived lung stem cells to construct these new models. 

The main areas of interest of the lab are: 

  • Design and use of biologic (acellular) and synthetic scaffolds in diverse manufacturing approaches to bioengineer new lung tissue for transplantation. 

  • Understand the role of the extracellular matrix in directing lung stem cell behaviour in vivo and ex vivo during regeneration (normal and pathologic)  

  • Build and validate new models of human lung tissue and chronic lung disease to reduce animal usage and for use as drug discovery and therapeutic screening platforms

Keywords: bioengineering, lung regeneration, biomaterials, stem cells, bioprinting, microfluidics, light sheet fluorescence microscopy, image analysis

Selected publications: 

Recent select publications:

Gvazava et al. Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos. Journal of the American Chemical Society. 2023, 145 (45): 24796–24808. Link

Ptasinski et al. Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids. Life Science Alliance. 2023, 6(8):e202201853. Link

Da Silva et al. Formalin-free fixation and xylene-free tissue processing preserves cell-hydrogel interactions for histological evaluation of 3D calcium alginate tissue engineered constructs. Front Biomaterial Science 2023, 2:1155919. Link

Alsafadi et al. Simultaneous isolation of proximal and distal lung progenitor cells from individual mice using a 3D printed guide reduces proximal cell contamination of distal lung epithelial cell isolations. Stem Cell Rep 2022, 17(12): 2718-2731. Link and Cover Article

De Santis et al. Extracellular matrix reinforced bioinks for 3D bioprinting human tissue. Adv Materials 2021, 33(3):2005476. Link

Complete Publication List:

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