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Céline Aguer - Assistant Professor

 

F-1033, University du Québec en Outaouais (office hours: Tuesdays, 9-12 am)
Phone: (819) 595-3900 ext. 2527

1E103, Hôpital Montfort
Phone: (613) 746-4621 ext. 6047

celine.aguer [at] mcgill.ca

Dr. Céline Aguer combines her expertise in exercise physiology and biochemistry to understand how muscle metabolic defects contribute to the development of insulin resistance and type 2 diabetes. The overarching goal of her research program is to better understand how some environmental factors such as exercise and environmental pollutants may alter skeletal muscle energy metabolism. She is using an integrated approach in the study of muscle metabolism and exercise physiology ranging from metabolic pathways at the cellular level to exercise physiology at the whole-body level. She is particularly interested in the cross-talk between muscle and different tissues (e.g. adipose tissue, pancreatic islets) in the development of type 2 diabetes.

Her research lab is located at the Institut du Savoir Montfort in Ottawa, ON. At McGill she teaches physiology and she is the student academic advisor in the Med-P program, Outaouais campus.

Education:

Postdoctorate, Biochemistry, Faculty of Medicine, University of Ottawa, 2009-2013

Ph.D., Sciences chimique et biologique pour la Santé, Université Montpellier 1, France, 2008

M.Sc., Physiologie de l’exercice, Université du Sud Toulon-Var, France, 2005


List of recent publications (* indicates supervised students)

  1. C. Aguer, E. Loro, D. Di Raimondo. (2020) Editorial: The Role of Muscle Secretome in Health and Disease. Frontiers in Physiology. doi: 10.3389/fphys.2020.01101
  2. R. Al Batran, K. Gopal, M.E. Capozzi, J.J. Chahade, B. Saleme, S.A. Tabatabaei-Dakhili, A.A. Greenwell, J. Niu, M. Almutairi, N.J. Byrne, G. Masson, R, Kim, F. Eaton, E.E. Mulvihill, L. Garneau*, A.R. Masters, Z. Desta, C.A. Velázquez-Martínez, C. Aguer, P.A. Crawford, G. Sutendra, J.E. Campbell, J.R.B. Dyck, J.R. Ussher. (2020) Pimozide alleviates obesity-induced dysglycemia via inhibiting skeletal muscle ketone body oxidation. Cell Metabolism. S1550-4131(20)30132-7. doi: 10.1016/j.cmet.2020.03.
  3. L. Garneau*, S. A. Parsons, S. R. Smith, E. E. Mulvihill, L. M. Sparks$, C. Aguer$. $co-corresponding authors. (2020) Plasma Myokine Concentrations After Acute Exercise in Non-Obese and Obese Sedentary Women. Frontiers in Physiology. 11:18. doi:10.3389/fphys.2020.00018
  4. F. Ahmed*,$, L. Chehadé*,$, L. Garneau*, A. Caron*, C. Aguer. $co-first authors. (2020) The effects of acute BPA exposure on skeletal muscle mitochondrial function and glucose metabolism. Mol Cell Endocr. 499:110580. doi:10.1016/j.mce.2019.110580
  5. K.A. Hutchinson, S. Mohammad, L. Garneau*, K. McInnis, C. Aguer, K.B. Adamo. (2019) Examination of the myokine response in pregnant and non-pregnant women following an acute bout of moderate-intensity walking. Frontiers in Physiology. 10:1188. doi:10.3389/fphys.2019.
  6. E. Guérin, H. Jaafar*, L. Amrani*, D. Prud’homme, C. Aguer. (2019) Intervention strategies to prevent comorbid depression among individuals with type 2 diabetes: a scoping review. Frontiers in Public Health. 5:7-35. doi:10.3389/fpubh.2019.00035
  7. L. Garneau*, C. Aguer. (2019) Role of myokines in the development of muscle insulin resistance and related metabolic defects in type 2 diabetes. Diabetes and Metabolism. 45(6):505-516. doi:10.1016/j.diabet.2019.02.006
  8. L. Nadeau*, C. Aguer. (2019) Reply to “Discussion of ‘Interleukin-15 as a myokine: mechanistic insight into its effect on skeletal muscle metabolism’ -- Interleukin-15 and interleukin-15Rα-dependent/-independent functions in human skeletal muscle are largely unknown”. Applied Physiology, Nutrition, and Metabolism. 44(3):338-339. doi:10.1139/apnm-2018-0823
  9. C. Tremblay Laganière*, L. Garneau*, J.F. Mauger*, V. Peshdary, E. Atlas, A.S. Nikolla*, N.A. Chapados, C. Aguer. (2019) Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function. Environ Sci Pollut Res. 26(3):2375-2386. doi:10.1007/s11356-018-3738-8
  10. L. Nadeau*, D.A. Patten, A. Caron*, L. Garneau*, E. Pineault-Masson*, M. Foretz, P. Haddad*, B.G. Anderson, L. Quinn, M.-E. Harper, C. Aguer. (2019) IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation. BBA General Subject. 1863:395-407. doi:10.1016/j.bbagen.2018.10.
  11. L. Nadeau*, C. Aguer. (2019) Interleukin-15 as a myokine: mechanistic insights into its effects on skeletal muscle metabolism. Invited review in Applied Physiology, Nutrition, and Metabolism. 44(3):229-238. doi:10.1139/apnm-2018-
  12. C. Dubé, C. Aguer, K. Adamo, S. Bainbridge. (2017) A role for maternally derived myokines to optimize placental function and fetal growth across gestation. Applied Physiology, Nutrition, and Metabolism, 42(5):459-469. doi:10.1139/apnm-2016-0446
  13. D.P. Blondin, A. Daoud*, T. Taylor, H. Tingelstad, V.Bézaire, D. Richard, A.C. Carpentier, A.W. Taylor, M.-E. Harper, C. Aguer$, F. Haman$. $co-corresponding authors. (2017) Four-weeks of cold acclimation in adult humans shifts the ATPase-independent source of heat production from skeletal muscle to BAT. J Physiol, 595(6):2099-2113. doi:10.1113/JP273395
  14. L. Chehadé*,$, A. Caron*,$, C. Aguer. $co-first authors. (2016) Role of Environmental Pollutants in Skeletal Muscle Insulin Resistance and Mitochondrial Dysfunction. Invited review in Environment and Natural Resources Research, 6(4): 60-78. 10.5539/enrr.v6n4p60
  15. J.-F. Mauger*,$, L. Nadeau*,$, A. Caron*, N. Ann Chapados, C. Aguer. $co-first authors. (2016) Polychlorinated biphenyl 126 exposure in vitro in L6 myotubes alters glucose metabolism: a pilot study. Environ Sci Pollut Res, 23(8):8133-40. doi:10.1007/s11356-016-6348-3

Full list of publications: https://pubmed.ncbi.nlm.nih.gov/?term=celine+aguer&sort=date

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