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Department of Physiology McGill University McIntyre Medical Sciences Bldg, Room 1120 3655 Promenade Sir William Osler Montréal, Québec H3A 1Y6 phone: 514-398-1743 phone (lab): 514-398-3639 email: Anmar.Khadra [at] mcgill.ca Laboratory web site: http://www.medicine.mcgill.ca/physio/khadralab/ Master's and Ph.D. Positions Available |
Research Area: Applied Mathematics
Research Description:
The core focus of my research program is to understand the interactions and mechanisms underlying the behaviour of various physiological systems using mathematical and computational approaches. I use these approaches to (i) provide important insights into the cellular and molecular processes regulating these systems; (ii) test experimental hypotheses; (iii) identify targets to manipulate their dynamics; (iv) determine the causes of abnormalities exhibited by them; and (v) ultimately develop technological tools to decipher their kinetics. The mathematical models that emerge from these studies raise intriguing mathematical questions that I then analyze either numerically, using computational tools, or theoretically, using methods of nonlinear and stochastic dynamics. This work is conducted in close collaboration with several renowned national and international experimental laboratories. For more details, please visit: http://www.medicine.mcgill.ca/physio/khadralab/
Selected Publications:
R.P.D. Alexander, J. Mitry, V. Sareen, A. Khadra, D. Bowie. Cerebellar Stellate Cell Excitability is Coordinated by Shifts in the Gating Behavior of Voltage-Gated Na+ and A-type K+ Channels. eNeuro, in press, 2019.
J. Lehnert and A. Khadra. How Pulsatile Kisspeptin Stimulation and GnRH Autocrine Feedback Can Drive GnRH Secretion: A Modeling Investigation. Endocrinology, 160, 1289–1306, 2019.
K. Tang, C.G. Boudreau, C.M. Brown and A. Khadra. Paxillin Phosphorylation at Serine 273 and its Effects on Rac, Rho and Adhesion Dynamics. PLoS Computational Biology, 14, e1006303, 2018.
S. Singha, K. Shao, Y. Yang, X. Clemente-Casares, P. Solé, A. Clemente, J. Blanco, Q. Dai, F. Song, S.W. Liu, J. Yamanouchi, C.S. Umeshappa, R.H. Nanjundappa, P. Detampel, M. Amrein, C. Fandos, R. Tanguay, S. Newbigging, P. Serra, A. Khadra, W.C.W Chan and P. Santamaria. Peptide-MHC-Based Nanomedicines for Autoimmunity Function as T-Cell Receptor Microclustering Devices. Nature Nanotechnology, 12, 701-710, 2017.
L. Mackay, H. Zemkova, S.S. Stojilkovic, A. Sherman, A. Khadra. Deciphering the Regulation of P2X4 Receptor Channel Gating by Ivermectin Using Markov Models. PLoS Computational Biology, 13, e1005643, 2017.
L. Mackay, N. Mikolajewicz, S.V. Komarova and A. Khadra. Systematic Characterization of Dynamic Parameters of Intracellular Calcium Signals. Frontier in Physiology, 7, 525, 2016.
S. Moran, S.M. Moenter and A. Khadra. A Unified Model for Two Modes of Bursting in GnRH Neurons. Journal of Computational Neuroscience, 40, 297-315, 2016.
A. Khadra and S. Schnell. Development, Growth and Maintenance of Beta-Cell Mass: Models are also Part of the Story. Molecular Aspects of Medicine, Special Issue: Recent Advances in Pancreatic Beta Cell Failure and Diabetes, 42, 42-60, 2015.
M. Jaberi-Douraki, S. Schnell, M. Pietropaolo and A. Khadra. Unraveling the Contribution of Pancreatic Beta-Cell Suicide in Autoimmune Type 1 Diabetes. Journal of Theoretical Biology, 375, 77-87, 2015.
H. Zemkova, A. Khadra, M.B. Rokic, V. Tvrdonova, A. Sherman and S.S. Stojilkovic. Allosteric Regulation of the P2X4 Receptor Channel Pore Dilation. Pflügers Archiv - European Journal of Physiology, 467, 713-726, 2015.
J. Sugarman, S. Tsai, P. Santamaria and A. Khadra. Quantifying the Importance of pMHC Valency, Total pMHC Dose and Frequency on Nanoparticle Therapeutic Efficacy. Immunology and Cell Biology, 91, 350-359, 2013.
. Khadra, Z. Yan, C. Coddou, M. Tomic, A. Sherman and S.S. Stojilkovic. Gating Properties of the P2X2a and P2X2b Receptor Channels: Experiments and Mathematical Modeling. Journal of General Physiology, 139, 333-348, 2012.
Z. Yan, A. Khadra, S. Li, M. Tomic, A. Sherman and S.S. Stojilkovic. Experimental Characterization and Mathematical Modeling of the P2X7 Receptor Channel Gating. Journal of Neuroscience, 30, 14213-14224, 2010.
A. Khadra, S. Tsai, P. Santamaria and L. Edelstein-Keshet. On How Monospecific Memory-Like Autoregulatory CD8+ T Cells Can Blunt Diabetogenic Autoimmunity: A Computational Approach. Journal of Immunology, 185, 5962-5972, 2010.