There has been significant progress over the last decade in understanding the molecular basis by which sensory neurons transduce and subsequently transmit noxious (ie. tissue damaging) stimuli giving rise to the sensation of pain.
Do you ever wonder what is in the air you breathe? You should- given that you take around 20,000 breaths per day.
In the developing nervous system, an enormous number and diversity of neurons are precisely organized into neural circuits. How can such a vast set of neural connections be wired using limited cues encoded in our genomes?
Fructose is a simple sugar found in fruit and honey, but it is also used as sweeteners via added sugars, syrups, or high fructose corn syrup in processed foods or beverages.
The normal heartbeat is conditioned by transient increases in the intracellular free Ca2+ concentration. Ca2+ influx in cardiomyocytes is regulated by the activity of the heteromeric L-type voltage-activated CaV1.2 channel.
Acute myeloid leukemia (AML) is an aggressive cancer of the myeloid lineage of the blood system. Prior work has shown that a rare subset of leukemic stem cells (LSCs) is able to propagate the disease.
Mutation or disruption of the SHANK3 (SH3 domain and ankyrin repeat) gene at the 22q13.3 locus represents a highly penetrant, monogenic risk-factor for Autism Spectrum Disorder (ASD) and is a leading cause of Phelan–McDermid Syndrome (PMS).
This event is part of the Department of Physiology Friday Seminar Series and is co-sponsored by the Alan Edwards Centre for Research on Pain (AECRP)
The human naive T-cell receptor (TCR) repertoire is extremely diverse and accurately estimating its distribution is challenging.