Associate Members

Name & Address

Research

Jack Antel
jack.antel [at] mcgill.ca (jack.antel@mcgill.ca)
(514) 398-8531

Montreal Neurological Institute
Neuroimmunology Unit
3801 University Street, Room 111
Montreal, Quebec H3A 2B4

Our studies focus on the mechanisms underlying the interactions between the immune system and central nervous system (CNS) and how such interactions contribute to the tissue injury observed in such human neurologic disorders as multiple sclerosis, HIV encephalopathy, and Alzheimer's disease.

Curtis Baker
curtis.baker [at] mcgill.ca
(514) 934-1934, Ext 34819

McGill Vison Research, Ophthalmology
Royal Victoria Hospital
687 Pine Avenue W., H4-14
Montreal, Quebec H3A 1A1

Signal processing mechanisms of early visual cortical areas, particularly the representation of visual motion and texture, studied with approaches of single unit neurophysiology, optical imaging, psychophysics, and computational modeling.

 

Daniel Bernard
daniel.bernard [at] mcgill.ca
(514) 398-2525

McIntyre Medical Building
3655 Prom. Sir-William-Osler
Room 1315A
Montreal, QC, H3G 1Y6

 

Volker Blank
volker.blank [at] mcgill.ca
(514) 340-8260 ext. 24984

Lady Davis Institute for Medical Research
Jewish General Hospital
3755, Cote-Ste-Catherine Road
Montreal, QC H3T 1E2

Projects: 

1. Analysis of the role of cap 'n' collar (CNC) transcription factors in mammalian gene regulation, stress response and tumorigenesis.
2. Regulation of small Maf transcription factors by cytokines.

Website: http://www.ladydavis.ca/en/volkerblank

Mark Blostein
mark.blostein [at] mcgill.ca
(514) 340-8207

Jewish General Hospital
Room E-150
3755 Cote Sainte Catherine
Montreal, Québec H3T 1E2

Currently, my laboratory has three distinct focuses: 1) In vivo and in vitro characterization of gas6, a novel survival factor in endothelial cell physiology. 2) The design of hemostatic peptides to accelerate hemostasis and mitigate bleeding. This is a project funded by the Department of National Defense of Canada.  3) A collaborative study with the laboratory of Dr. Galipeau aimed at designing a novel gene therapeutic platform to treat hemophilia B.

Charles Bourque
charles.bourque [at] mcgill.ca
514-934-8094

Montreal General Hospital
Centre for Research in Neuroscience
1650 Cedar avenue Montréal, Québec H3G 1A4
Website:http://bourquelab.mcgill.ca/

 

The Bourque lab studies how the mammalian brain monitors the ratio of salt to water (fluid osmolality) via special neurons called osmoreceptors. We are interested in how mechanosensitive ion channels and neuro-glial interactions allow osmoreceptors to detect changes in extracellular fluid osmolality. We are also interested in how synaptic signals distributed in central osmoregulatory circuits mediate changes in behavior (thirst, salt appetite), hormone release and autonomic function to adjust blood pressure, blood volume and fluid osmolality. Finally, we are interested in mechanisms that modulate osmoregulatory circuits. In particular, we are investigating the basis for modulation by changes in blood volume and body temperature, as well as for the circadian modulation of osmoregulatory function. .

For details see the Bourque Lab Website: http://www.bourquelab.com/

Nicolas Cermakian
nicolas.cermakian [at] mcgill.ca
(514) 761-6131 Ext. 4936

Douglas Mental Health University Institute
Department of Psychiatry
McGill University
6875 LaSalle Blvd.
Montréal, Québec H4H 1R3

Molecular mechanisms of circadian clocks in mammals: (1) The regulation of clock genes and clock proteins. How do the gears of the biological clock function? How are they modulated?  (2) The circadian control of physiological processes, including sleep and immune response. (3) The study of human clock gene expression, in collaboration with Dr. Diane Boivin.
This work has implications for the understanding and treatment of sleep and mood disorders, as well as cancer. We use a combination of in vitro, cell culture, in vivo and behavioural approaches.

http://ncermakianlab.mcgill.ca

Andrey Cybulsky
andrey.cybulsky [at] mcgill.ca
(514) 937-1937 x 76299

Division of Nephrology
McGill University Health Centre
Research Insitute  Glen Site    EM13238 ,1001 Decarie BLvd.    
Montréal, Québec H4A 3J1
http://nephrology.mcgill.ca/resc.htm.

1) Mechanisms of immune glomerular cell injury and proteinuria. Role of phospholipases, protein kinases, and stress proteins. 2) Role of SLK (a Ste-20-like kinase) in renal ischemia-reperfusion injury. Mechanisms/regulation of kinase activation, signaling effectors, functional effects, including apoptotic pathways. 3) Regulation of protein kinase signaling by extracellular matrix in the glomerulus. Activation of protein kinases, mediators of apoptosis/cell survival. 

 

Jorg Fritz
jorg.fritz [at] mcgill.ca
(514) 398-1707 (office)
(514) 398-6417 (lab)
(514) 398-2603 (fax)

McGill Life Sciences Complex
Complex Traits Group
Bellini Pavilion
3649 Promenade Sir William Osler,
Room: 371 (Office) & 356 (Lab)
Montreal, QC H3G 0B1

The laboratory of Jörg Hermann Fritz focuses on understanding how innate host resistance regulates inflammatory and antigen-specific adaptive immune responses. In particular, he investigates how innate immune recognition of microbes and of infection-associated physiological changes activates pattern recognition molecules (PRM) such as Toll-like receptors (TLR) and Nod-like receptors (NLR) for the activation of mucosal and systemic immunity against commensal and pathogenic microorganisms. Focusing on the NLR members Nod1 and Nod2, the laboratory further studies the molecular and immunological consequences of innate immune recognition by non-hematopoietic stromal cells for the regulation of mucosal homeostasis as well as for the initiation of inflammatory and adaptive immune responses.

Daniel Guitton
daniel.guitton [at] mcgill.ca
(514) 398-1954

Montreal Neurological Institute
3801 University Street
Montréal, Québec H3A 2B4

Cortical and brainstem neural mechanisms underlying the control of eye and head movements. Visuo-motor mechanisms. Spatial coding and computational maps. Movement disorders.

Terence Hébert
terence.hebert [at] mcgill.ca
(514)398-1398 (office)
(514)398-8803 (lab)
(514)-398-6690 (FAX)

Department of Pharmacology & Therapeutics, McGill University
Room 1303
McIntyre Medical Sciences Building
3655 Promenade Sir William Osler
Montreal, Quebec
H3G 1Y6
 

Cells must discriminate among a plethora of signals and in many instances must be able to integrate signals coming from several different pathways. Thus, the cell must simultaneously facilitate this crosstalk between receptor pathways and paradoxically limit it in order to preserve specificity.The mechanisms which regulate specificity of G protein-coupled signalling systems in vivo are not well characterized. In vivo, GPCRs demonstrate much less promiscuity in their coupling to G proteins and effectors than in vitro. We feel it is therefore important to use cellular systems to begin to look at mechanisms of specificity. Thus, the question of specificity may be addressed by positing that signalling complexes are stable in these cells and that receptors, G proteins and effectors remain associated even while activated. Work in my lab is based on the idea that stable receptor/G protein/effector interactions can serve to explain the specificity inherent in these signal transduction.
(Recent Publications)

Tony Humphries
tony.humphries [at] mcgill.ca
(514) 398-3821

Room 1112, Burnside Hall
805 Sherbrooke West
Montreal, QC H3A 0B9

My research lies in the areas of mathematical modelling, numerical analysis and dynamical systems, often at the intersection of all three. Current and recent projects mainly focus on mathematical modelling of hematopoiesis, and investigating the dynamics, bifurcations and numerical analysis of the resulting delay differential equations including equations with state-dependent and distributed delays.

http://www.math.mcgill.ca/humphries/

Anne-Marie Lauzon
anne-marie.lauzon [at] mcgill.ca
(514) 934-1934 x96176

Research Institute MUHC Glen Site       

1001 Decarie Blvd. Montreal, Quebec    H4A 3J1

Primary research interest is to investigate the role of smooth muscle in airway hyperresponsiveness and asthma. Dr. Lauzon's current research program addresses this question in the following ways:
1) By investigating the smooth muscle myosin heavy chain isoform expression in human bronchial biopsies and in genetic and allergic models of airway hyperresponsiveness using such techniques as quantitative real-time PCR and Western blotting;
2) By investigating the biophysical molecular properties of different SMMHC isoforms and actin regulatory proteins using such techniques as the laser trap (to measure the unitary displacement and force generated by single myosin molecules) and the in vitro motility assay (to measure the velocity of actin filaments as they get propelled by myosin molcules);
3) To study the biophysical properties of airway smooth muscle at the strip level to dissect out the relative contribution of the mechanics of the contractile proteins and their activation mechanisms.
4) To investigate fundamental properties of smooth muscle such as the latch-state. Specifically, the role of different smooth muscle myosin isoforms and the role of MgADP in the formation of the latch-state are addressed.

James Martin
james.martin [at] staff.mcgill.ca
(514) 398-3864 ext 00137

Meakins-Christie laboratories
Department of Medicine
 

My research program is aimed at understanding the basis for asthma, a disease of epidemic proportions, through the study of cellular and animal models. The role of the T cell in airway narrowing and in inflammation is being addressed through techniques that quantify the responsiveness of the airways to bronchoconstrictive stimuli , allergen-induced bronchoconstriction and inflammation and airway remodeling. The current focus is on the role of Th2 cells, epidermal growth factor receptor and ligands and growth of airway smooth muscle. These studies are complemented by studies of isolated airway smooth muscle in culture alone and in co-culture with T cells. In vivo and in vitro indices of proliferation are used to track muscle growth, intracellular calcium signals to evaluate changes in contractile properties and flow cytometry to phenotype T cells.

Christopher Pack christopher.pack [at] mcgill.ca
(514) 398-1254

Montreal Neurological Institute
McGill University School of Medicine
3801 University Street, Room 896A
Montreal, Quebec H3A 2B4

Neurophysiology of vision and its relationship to perception, behaviour, and computation.
 

Satya Prakash
satya [at] bmed.mcgill.ca
(514) 398-3676

Department of Biomedical Engineering
Faculty of Medicine
McGill University
Lyman Duff Building
3775 University Street, Room 311
Montreal, Quebec
H3A 2B4

The primary research interests are in areas of artificial cell encapsulation, biomaterial and medical device engineering, tissue engineering, cell therapy and development of bioengineered controlled-release delivery system. The focus is to design artificial cell microcapsules that are capable of targeting specific sites and encapsulating genetically engineered cells and microorganisms, enzymes, small peptides, DNA and active drugs. Specifically, we are developing a system that integrates tissue engineering with gene and cell therapy methods with the aim to get therapeutic gene products to the targeted sites and maintain their functions for therapeutic applications by implanting live genetically engineered cells. Additionally, the research program is directed toward understanding the basic mechanisms that govern the use of microcapsules for oral delivery of therapeutic agents and developing support systems for artificial liver and kidney.

Shafaat Rabbani
shafaat.rabbani [at] mcgill.ca
(514) 934-1934 x35929

Basic Cancer Research
Department of Oncology
McGill University

Molecular mechanisms of cancer invasion and metastasis. Development of novel therapeutic strategies.

Keywords: Cancer metastasis, skeleton, Epigenetics, DNA methylation, urokinase and urokinase receptor.

The focus of research in my laboratory is to investigate the progression of hormone dependent malignancies (breast and prostate cancer). Toward these objectives, I am examining the role of urokinase (uPA) and its receptor (uPAR) in tumor invasion, growth, and metastasis. We are developing novel diagnostic and therapeutic strategies to block uPA production and its interaction with cell surface uPAR to block tumor growth and metastasis. Using our well established syngeneic, xenograft and transgenic models of cancer (breast, prostate ,melanoma, osteosarcoma) which closely mimics the behavior of these cancers including their propensity to develop skeletal metastasis, we are examining the efficacy of small molecules, peptides, monoclonal antibodies, oligonucleotides, and gene therapy for further evaluation in patients with these common cancers.

Another area of interest in my laboratory is “epigenetic regulation of gene expression in cancer”. Our genes are regulated by a set of chemical marks on DNA called DNA methylation. We discovered that if we used specific drugs that block the process of removal of DNA methylation, cancer metastasis was inhibited as well. Interestingly, the process of metastasis could be blocked with S-adenosylmethionine (SAMe), a universal methyl donor. This natural compound interferes with DNA demethylation. We then showed the ability of SAMe to prevent cancer growth and metastasis in several common cancers. Currently we are examining the effect SAMe in combination with already approved agents including immune checkpoint inhibitors. The studies will also examine in depth the mechanism of action of these agents alone and for any synergistic effects. Since SAMe is an approved nontoxic nutritional supplement results from these studies could be translated into new therapeutics strategies alone and in combination setting to prevent cancer development, growth, and metastasis.

Publications

Simon Rousseau
simon.rousseau [at] mcgill.ca
 (514) 934-1934 loc. 76394 

Meakins-Christie Laboratories
Medicine, Department of
MUHC GLEN

 

Edward S. Ruthazer
edward.ruthazer [at] mcgill.ca
(514) 398-4022

Department of Neurology and Neurosurgery
Montreal Neurological Institute

 

Jesper Sjostrom
jesper.sjostrom [at] mcgill.ca
(514) 934-1934 loc. 44561 (office)
(514) 934-8216 (fax)
(438) 826-1971 (cell)

Neurology and Neurosurgery, Department of
MONTREAL NEUROLOGICAL Institute & Hospital

 

Mary Stevenson
mary.m.stevenson [at] mcgill.ca
(514) 937-6011 ext 45077

Montreal General Hospital
Research Institute
1650 Cedar Avenue
Montréal, Québec H3G 1A4

Study of cellular mechanisms of genetically controlled resistance of inbred mice to rodent malaria species, Plasmodium chabaudi; role of macrophages and their mediators in resistance to infection with intracellular bacteria and parasites.

Tomoko Takano
tomoko.takano [at] mcgill.ca
(514) 398-21711

Nephrology Research
McGill University
Duff Medical Building
3775 University, Room 229
Montreal, Quebec H3A 2B4

Role of lipid mediators in glomerular epithelial cell injury, with a particular focus on the role of cyclooxygenase products. 2. Mechanisms of glomerular barrier dysfunction: role of the actin cytoskeleton. Technique used: cell biology, molecular biology, protein biochemistry, small animal experiments, lipid biochemistry.

Elena Torban
elena.torban [at] mcgill.ca
(514) 934-1934 x 76116

Department of Medicine
MUHC GLEN

 

 

Simon S. Wing
simon.wing [at] mcgill.ca
(514) 934-1934 x 76184

Department of Medicine, Division of Endocrinology & Metabolism
MUHC GLEN

https://www.mcgill.ca/endocrinology/facultydir/wingsimon
 

 

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