Yves De Koninck
Our research focuses on the physiological, pharmacological and anatomical bases of synaptic transmission, with a particular emphasis on cellular substrates of pathological conditions in the Central Nervous System (CNS). Our recent work focuses on three main themes:
- synaptic mechanisms in the sensory spinal cord and their plasticity during development and in experimental models of chronic pain;
- synaptic changes in the neocortex during ageing and Alzheimer’s disease;
- the impact of synaptic activity on the computational properties of neurons.
We use a wide array of approaches, including electrophysiological recording in vivo (micro-optrodes) and in vitro (patch clamp in slices), multiphoton and other non-linear imaging techniques, time-resolved fluorescence microscopy, in vivo optogenetics, tissue-based biochemical analysis, neural tracing and immunocytochemistry, and computational approaches.
The lab is also actively involved in the development of novel photonics technique development, including fluctuation analysis of fluorescent signals, fibreoptic-based probe development, novel microscopy techniques and neural modeling approaches.