|Department of Physiology|
McIntyre Medical Sciences Building,
3655 Promenade Sir William Osler
Montréal, Québec H3G 1Y6
monroe [dot] cohen [at] mcgill [dot] ca
Research Area: Neurophysiology
My research is aimed at understanding how the formation and development of presynaptic and postsynaptic specializations are regulated during nerve-muscle synaptogenesis. Currently our focus is on the development and alignment of presynaptic active zones and postsynaptic junctional folds. This work is carried out on cultures of embryonic Xenopus nerve and muscle cells as well as on neuromuscular junctions formed in vivo. Fluorescent staining and microscopy is used to assess the distribution of the specific synaptic molecules.
Education: Ph.D., McGill
Cohen MW, Moody-Corbett F, Godfrey EW.
Neuritic deposition of agrin on culture substrate: implications for nerve-muscle synaptogenesis.
J Neurosci. 1994 May;14(5 Pt 2):3293-303.
Cohen MW, Jacobson C, Godfrey EW, Campbell KP, Carbonetto S.
Distribution of alpha-dystroglycan during embryonic nerve-muscle synaptogenesis.
J Cell Biol. 1995 May;129(4):1093-101.
Cohen MW, Jacobson C, Yurchenco PD, Morris GE, Carbonetto S.
Laminin-induced clustering of dystroglycan on embryonic muscle cells: comparison with agrin-induced clustering.
J Cell Biol. 1997 Mar 10;136(5):1047-58.
Cohen MW, Hoffstrom BG, DeSimone, DW (PDF file)
Active zones on motor nerve terminals contain α3ß1 integrin. J. Neurosci. 2000 Jul; 20(13): 4912-4921.