Isadore Rosenfeld Chair in Cardiology
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Department of Physiology McGill University McIntyre Medical Sciences Building, Room 1118 3655 Promenade Sir William Osler Montréal, Québec H3G 1Y6 (514) 398-4338 glass [at] cnd.mcgill.ca |
Research Area: Dynamics of Physiological Control
Research Description:
Leon Glass carries out research on various aspects of application of nonlinear dynamics to physiology and medicine. In particular he has worked on problems associated with respiratory rhythmogenesis and the effects of periodic forcing on respiration, dynamics of tremor and motor control, dynamics of cardiac arrhythmia, visual perception, and dynamics in gene networks. Current research involves studying dynamics of complex dynamics in experimental and theoretical models of cardiac arrhythmias with an emphasis on understanding the mechanisms that lead to the transition from normal heart rhythms to pathological rhythms. Other current projects deal with dynamics in equations that model genetic networks and understanding the evolution of genetic control networks.
Education: Ph.D., Chicago
Recent Publications:
L. Glass.
Synchronization and rhythmic processes in physiology. Nature 410, 277-284 (2001)
G. Bub, A. Shrier, L. Glass.
Global organization of dynamics in oscillatory heterogeneous excitable media. Physical Review Letters 94, 028105 (2005).
V. Lemaire, C. F. Lee, J. Lei, R. Metivier, L. Glass.
Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. Physical Review Letters, 96, 198102, 2006.
T. J. Perkins, J. Jaeger, J. Reinitz, L. Glass.
Reverse engineering the gap gene network of Drosophila melanogaster. PLoS Computational Biology, 2(5), e51 (2006), 2006.
C. Lerma, C. F. Lee, L. Glass, A. L. Goldberger.
The rule of bigeminy revisited: Analysis in sudden cardiac death syndrome. Journal of Electrocardiology, 40, 78-88, 2007.