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Associate Members

Name & Address

Research

Jack Antel
jack [dot] antel [at] mcgill [dot] ca (jack.antel@mcgill.ca)
(514) 398-8550/8531
Montreal Neurological Institute
Neuroimmunology Unit
3801 University Street, Room 111
Montreal, Quebec H3A 2B4
Our studies focus on the mechanisms underlying the interactions between the immune system and central nervous system (CNS) and how such interactions contribute to the tissue injury observed in such human neurologic disorders as multiple sclerosis, HIV encephalopathy, and Alzheimer's disease.
Massimo Avoli
massimo [dot] avoli [at] mcgill [dot] ca
(514) 398-1952
Montreal Neurological Institute
Neurology and Neurosurgery
3801 University Street
Montréal, Québec H3A 2B4
We employ electrophysiological and molecular techniques to examine the excitability of cortical neurons in rats and mice. Our work focuses on the interplay of inhibitory and excitatory influences, especially as they relate to the genesis of synchronicity in neuronal networks. These processes are fundamental for understanding the mechanisms underlying the generation of seizures in epileptic patients and for developing new anti-epileptic drugs. We are also stutying a mouse model of Fragile X syndrome to identify the alterations in inhibition that occur in a specific brain structure, the subiculum. This aspect might represent a fundamental mechanism in the pathophysiogenesis of this form of mental retardation.
Steven Backman
steven [dot] backman [at] muhc [dot] mcgill [dot] ca
(514) 934-1934 x 34884
Royal Victoria Hospital
Department of Anethesia
McGill University
 
Curtis Baker
curtis [dot] baker [at] mcgill [dot] ca
(514) 934-1934, Ext 34819
McGill Vison Research, Ophthalmology
Royal Victoria Hospital
687 Pine Avenue W., H4-14
Montreal, Quebec H3A 1A1
Signal processing mechanisms of early visual cortical areas, particularly the representation of visual motion and texture, studied with approaches of single unit neurophysiology, optical imaging, psychophysics, and computational modeling.

 

Nicole Bernard
nicole [dot] bernard [at] mcgill [dot] ca
(514) 934-1934 x44584
Montreal General Hospital
 
Volker Blank
volker [dot] blank [at] mcgill [dot] ca
(514) 340-8260, Ext 4984
Lady Davis Institute for Medical Research Department of Medicine
McGill University
3755 Cote Sainte-Catherine
Montreal, Québec H3T 1E2
Role of Maf and CNC transcription factors in mammalian gene regulation.  (1) Control of erythroid differentiation by NF-E2, a heterodimer of the CNC protein p45 and a small Maf factor.  (2) Role of the NC protein Nrf3 in the control of gene expression in humans and mice.  (3) Regulation of small Maf proteins by proinflammatory cytokines.

Our studies are aimed at a better understanding of the transcriptional networks governing oncogenesis, differentiation and stress response.  We are using a variety of experimental approaches including cell culture and in vivo models.
Mark Blostein
mark [dot] blostein [at] mcgill [dot] ca
(514) 340-8207
Jewish General Hospital
Room E-150
3755 Cote Sainte Catherine
Montreal, Québec H3T 1E2
Currently, my laboratory has three distinct focuses: 1) In vivo and in vitro characterization of gas6, a novel survival factor in endothelial cell physiology. 2) The design of hemostatic peptides to accelerate hemostasis and mitigate bleeding. This is a project funded by the Department of National Defense of Canada.  3) A collaborative study with the laboratory of Dr. Galipeau aimed at designing a novel gene therapeutic platform to treat hemophilia B.
Charles Bourque
charles [dot] bourque [at] mcgill [dot] ca
514-934-8094
Montreal General Hospital
Centre for Research in Neuroscience
1650 Cedar avenue Montréal, Québec H3G 1A4
Website:http://bourquelab.mcgill.ca/

 
The Bourque lab studies how the mammalian brain monitors the ratio of salt to water (fluid osmolality) via special neurons called osmoreceptors. We are interested in how mechanosensitive ion channels and neuro-glial interactions allow osmoreceptors to detect changes in extracellular fluid osmolality. We are also interested in how synaptic signals distributed in central osmoregulatory circuits mediate changes in behavior (thirst, salt appetite), hormone release and autonomic function to adjust blood pressure, blood volume and fluid osmolality. Finally, we are interested in mechanisms that modulate osmoregulatory circuits. In particular, we are investigating the basis for modulation by changes in blood volume and body temperature, as well as for the circadian modulation of osmoregulatory function. .

For details see the Bourque Lab Website: http://www.bourquelab.com/

Salvatore Carbonetto
sal [dot] carbonetto [at] mcgill [dot] ca (sal.carbonetto@mcgill.ca)
(514) 934-8058
Montreal General Hospital
Centre for Research in Neuroscience
1650 Cedar avenue
Montréal, Québec H3G 1A4
Cell Biology of neuronal differentiation and nerve regeneration in culture; control of these processes by growth factors and components of extracellular matrix.
Nicolas Cermakian
nicolas [dot] cermakian [at] mcgill [dot] ca
(514) 761-6131 Ext. 4936
Douglas Mental Health University Institute
Department of Psychiatry
McGill University
6875 LaSalle Blvd.
Montréal, Québec H4H 1R3
Molecular mechanisms of circadian clocks in mammals: (1) The regulation of clock genes and clock proteins. How do the gears of the biological clock function? How are they modulated?  (2) The circadian control of physiological processes, including sleep and immune response. (3) The study of human clock gene expression, in collaboration with Dr. Diane Boivin.

This work has implications for the understanding and treatment of sleep and mood disorders, as well as cancer. We use a combination of in vitro, cell culture, in vivo and behavioural approaches.

http://ncermakianlab.mcgill.ca

Andrey Cybulsky
andrey [dot] cybulsky [at] mcgill [dot] ca
(514) 398-8148
Lyman Duff Building
Nephrology Laboratory
3775 University Street
Montréal, Québec H3A 2B4

http://nephrology.mcgill.ca/resc.htm.
1) Mechanisms of immune glomerular cell injury and proteinuria. Role of phospholipases, protein kinases, and stress proteins. 2) Role of SLK (a Ste-20-like kinase) in renal ischemia-reperfusion injury. Mechanisms/regulation of kinase activation, signaling effectors, functional effects, including apoptotic pathways. 3) Regulation of protein kinase signaling by extracellular matrix in the glomerulus. Activation of protein kinases, mediators of apoptosis/cell survival. 

 

Bernardo Oscar Dubrovsky
bernardo [dot] dubrovsky [at] mcgill [dot] ca
(514) 398-5831
Neurophysiology
Department of Psychiatry
 
Daniel Guitton
daniel [dot] guitton [at] mcgill [dot] ca
(514) 398-1954
Montreal Neurological Institute
3801 University Street
Montréal, Québec H3A 2B4
Cortical and brainstem neural mechanisms underlying the control of eye and head movements. Visuo-motor mechanisms. Spatial coding and computational maps. Movement disorders.
Terence Hébert
terence [dot] hebert [at] mcgill [dot] ca
(514)398-1398 (office)
(514)398-8803 (lab)
(514)-398-6690 (FAX)

Department of Pharmacology & Therapeutics, McGill University
Room 1303
McIntyre Medical Sciences Building
3655 Promenade Sir William Osler
Montreal, Quebec
H3G 1Y6
 
Cells must discriminate among a plethora of signals and in many instances must be able to integrate signals coming from several different pathways. Thus, the cell must simultaneously facilitate this crosstalk between receptor pathways and paradoxically limit it in order to preserve specificity.The mechanisms which regulate specificity of G protein-coupled signalling systems in vivo are not well characterized. In vivo, GPCRs demonstrate much less promiscuity in their coupling to G proteins and effectors than in vitro. We feel it is therefore important to use cellular systems to begin to look at mechanisms of specificity. Thus, the question of specificity may be addressed by positing that signalling complexes are stable in these cells and that receptors, G proteins and effectors remain associated even while activated. Work in my lab is based on the idea that stable receptor/G protein/effector interactions can serve to explain the specificity inherent in these signal transduction.
(Recent Publications)
Geoffrey Hendy
geoffrey [dot] hendy [at] mcgill [dot] ca
(514) 842-1231 ext 1632
Royal Victoria Hospital
Calcium Research Laboratory
687 Pine Avenue West Room H4.67
Montréal, Québec H3A 1A1
Research investigation of molecular biology of calcium regulating hormones.
Robert E. Kearney
robert [dot] kearney [at] mcgill [dot] ca
(514) 398-6737
Department of Biomedical Engineering 3775 University Street
Montreal, Quebec H3A 2B4
Normal and pathological human neuro muscular control; physiological applications of signal analysis and systems identification; biomedical engineering; medical computing.

 

 

Louise Larose
louise [dot] larose [at] mcgill [dot] ca
(514) 398-5844
Polypeptide Laboratory
Strathcona Dentistry Building
Room W315
The goal of our research is to further understand intracellular signaling pathways at the molecular level in order to decipher alterations responsible for the development of human pathologies such as cancer and diabetes. Currently, the laboratory focuses on the role of the adaptor protein Nck in regulating the activity of various signaling pathways initiated in cells exposed to various stress conditions. We use a combination of in vitro and in vivo approaches (cellular and animal models) to investigate the impact of Nck and other adaptor proteins on various aspects of regulation of signaling events and associated biological responses. Our long term research goal is to identify novel therapeutic targets and prognostic indicators of human diseases, particularly cancer and diabetes.
Anne-Marie Lauzon
anne-marie [dot] lauzon [at] mcgill [dot] ca
(514) 398-3864 x 00130
Meakins-Christie Laboratories
Department of Medicine
Saint Urbain 3626
 
Primary research interest is to investigate the role of smooth muscle in airway hyperresponsiveness and asthma. Dr. Lauzon's current research program addresses this question in the following ways:
1) By investigating the smooth muscle myosin heavy chain isoform expression in human bronchial biopsies and in genetic and allergic models of airway hyperresponsiveness using such techniques as quantitative real-time PCR and Western blotting;
2) By investigating the biophysical molecular properties of different SMMHC isoforms and actin regulatory proteins using such techniques as the laser trap (to measure the unitary displacement and force generated by single myosin molecules) and the in vitro motility assay (to measure the velocity of actin filaments as they get propelled by myosin molcules);
3) To study the biophysical properties of airway smooth muscle at the strip level to dissect out the relative contribution of the mechanics of the contractile proteins and their activation mechanisms.
4) To investigate fundamental properties of smooth muscle such as the latch-state. Specifically, the role of different smooth muscle myosin isoforms and the role of MgADP in the formation of the latch-state are addressed.
 
Serge Lemay
serge [dot] lemay [at] mcgill [dot] ca
(514) 398-2762
MMcGill University Health Centre
Department of Medicine, Division of Nephrology
Lyman-Duff Building, Room 228
3775 University Street
Montreal, Quebec H3A 2B4
Research in Tyrosine kinase signaling and the role of Dok-4 and Eph receptors in epithelial cell function.
James Martin
james [dot] martin [at] staff [dot] mcgill [dot] ca
(514) 398-3864 ext 00137
Meakins-Christie laboratories
Department of Medicine
 
My research program is aimed at understanding the basis for asthma, a disease of epidemic proportions, through the study of cellular and animal models. The role of the T cell in airway narrowing and in inflammation is being addressed through techniques that quantify the responsiveness of the airways to bronchoconstrictive stimuli , allergen-induced bronchoconstriction and inflammation and airway remodeling. The current focus is on the role of Th2 cells, epidermal growth factor receptor and ligands and growth of airway smooth muscle. These studies are complemented by studies of isolated airway smooth muscle in culture alone and in co-culture with T cells. In vivo and in vitro indices of proliferation are used to track muscle growth, intracellular calcium signals to evaluate changes in contractile properties and flow cytometry to phenotype T cells.
Christopher Pack
christopher [dot] pack [at] mcgill [dot] ca
(514) 398-1254
Montreal Neurological Institute
McGill University School of Medicine
3801 University Street, Room 896A
Montreal, Quebec H3A 2B4
Neurophysiology of vision and its relationship to perception, behaviour, and computation.
 
Barry Posner
barry [dot] posner [at] mcgill [dot] ca
(514) 398-4101
Royal Victoria Hospital
Polypeptide Hormone Laboratory
687 Pine Avenue West
Montréal, Québec H3A 1A1
Receptor Tyrosine Kinases; Insulin; Insulin-like growth factors (IGFs).
My laboratory focuses on the study of insulin and growth factor action with a particular emphasis on their relationship to the pathogenesis of Type 2 Diabetes Mellitus. Both insulin and IGF bind to their cell surface receptors, which are tyrosine kinases, leading to their activation and internalization into the endosomal system. Novel substrates of both the insulin receptor kinase (IRK) and the EGF receptor kinase (EGFRK) have been identified within endosomes. We identified a novel class of phosphotyrosine phosphatase (PTP) inhibitors - the peroxovanadium (pV) compounds - as potent insulin mimickers. pVs promote activation of the IRK, both in situ and in vivo by inhibiting an IRK-associated PTP, leading to IRK activation and a range of insulin effects, including hypoglycemia in normal and diabetic rats. A current focus is on the role of intraendosomal processes as regulators of IRK function. These include the modulation of intraendosomal pH, a specific endosomal acidic insulinase (EAI), and PTPs, all of which modulate IRK activation and insulin signaling. Defects in one or more of these processes could contribute to the pathogenesis of T2DM. In a recent collaboration we employed Genome wide scanning and proteomics to identify a number of novel genes and proteins which could contribute to the development of T2DM. We are following up these studies to further our understanding of insulin and growth factor signalling and their abnormalities. In this regard emphasis is being placed on how EGF and insulin signalling use very similar intracellular pathways and yet produce responses highly specific to each agent.

Publications

Satya Prakash
satya [at] bmed [dot] mcgill [dot] ca
(514) 398-3676
Department of Biomedical Engineering
Faculty of Medicine
McGill University
Lyman Duff Building
3775 University Street, Room 311
Montreal, Quebec
H3A 2B4
The primary research interests are in areas of artificial cell encapsulation, biomaterial and medical device engineering, tissue engineering, cell therapy and development of bioengineered controlled-release delivery system. The focus is to design artificial cell microcapsules that are capable of targeting specific sites and encapsulating genetically engineered cells and microorganisms, enzymes, small peptides, DNA and active drugs. Specifically, we are developing a system that integrates tissue engineering with gene and cell therapy methods with the aim to get therapeutic gene products to the targeted sites and maintain their functions for therapeutic applications by implanting live genetically engineered cells. Additionally, the research program is directed toward understanding the basic mechanisms that govern the use of microcapsules for oral delivery of therapeutic agents and developing support systems for artificial liver and kidney.
Shafaat Rabbani
shafaat [dot] rabbani [at] mcgill [dot] ca
(514) 934-1934 x35929
Basic Cancer Research
Department of Oncology
McGill University
Investigation of the molecular mechanisms of prostate and breast cancer invasion and metastasis. Development of novel therapeutic strategies.

The focus of research in my laboratory is to investigate the progression of hormone dependent malignancies (breast and prostate cancer). Toward these objectives, I am examining the role of urokinase (uPA) in the process of tumor invasion, growth and metastasis. The change in the methylation status of uPA promoter is being evaluated as the epigenetic mechanism regulating uPA gene transcription in normal, early, and late stage breast and prostate cancer. We are developing novel diagnostic and therapeutic strategies to block uPA production and its interaction with cell surface uPAR to block tumor growth and metastasis. Using our well established models of breast and prostate cancer which closely mimics the behavior of these cancers including their propensity to develop skeletal metastasis, we are examining the efficacy of small molecules, peptides, monoclonal antibodies, oligonucleotides, and gene therapy for further evaluation in patients with these common cancers. Additionally we are developing highly sensitive and reliable molecular approaches to determine the levels of uPA expression including methylation specific PCR which can predict the methylation status of uPA, invasive potential of tumor cells and response to therapy. These results will help design an effective therapeutic strategy to block uPA/uPAR interaction.

Since both breast and prostate cancer have a high propensity to develop skeletal metastases we are continuing to examine the role of parathyroid hormone related peptide (PTHrP) in hypercalcemia of malignancy. Using our syngeneic and xenograft models of prostate and breast cancer we are examining the capacity of peptides and small molecules directed against prostate secretory proteins, integrins and intracellular signaling pathways to block the development and progression of skeletal metastases.

Publications
 
David Ragsdale
dragsdale [at] mni [dot] mcgill [dot] ca
(514) 398-6644
Montreal Neurological Institute
Department of Neurology & Neurosurgery
McGill University
3801 University
Montreal, Quebec H3A 2B4
Research interests in the structure and function of voltage-gated ion channels.
Dilson E. Rassier
dilson [dot] rassier [at] mcgill [dot] ca
(514) 398-4184, ext 0558
McGill University
Department of Kinesiology and Physical Education Education, Faculty of
CURRIE Gymnasium
Research focuses on the molecular and cellular mechanisms of skeletal muscle contraction and force regulation. The general objective is to understand how muscle molecules interact and convert chemical energy into mechanical work, causing muscle contraction. To achieve this objective the laboratory uses an array of experimental preparations, including single muscle cells, isolated myofibrils and sarcomeres, and myosin/actin filaments.
Charles Vaclav Rohlicek
charles [dot] rohlicek [at] mcgill [dot] ca
(514) 412-4423
Montreal Children's Hospital
Room D-365
2300 Tupper Street
Montreal, Quebec
H3H 1P3

 
Research in the effects of neonatal hypoxia on cardiac function in later life.
Edward S. Ruthazer
edward [dot] ruthazer [at] mcgill [dot] ca
(514) 398-4022
Department of Neurology and Neurosurgery
Montreal Neurological Institute
3801 University Street
Montreal, Quebec
H3A 2B4
 
Bernard Segal
b [dot] segal [at] sympatico [dot] ca
(514) 340-8222 ext 5987
Jewish General Hospital
Dept. of Otolaryncology
3755 Cote Ste. Catherine Road room E266
Montréal, Québec H3T 1E2
Basic and clinical study of vestibular study and optokinetic mechanisms, employing both behavioural and mathematical approaches.
Amir Shmuel
amir [dot] shmuel [at] mcgill [dot] ca
(514) 398-21922
Department of Neurology and Neurosurgery
Montreal Neurological Institute
3801 University Street
Montreal, Quebec
H3A 2B4
 
Mary Stevenson
mary [dot] m [dot] stevenson [at] mcgill [dot] ca
(514) 937-6011 ext 45077
Montreal General Hospital
Research Institute
1650 Cedar Avenue
Montréal, Québec H3G 1A4
Study of cellular mechanisms of genetically controlled resistance of inbred mice to rodent malaria species, Plasmodium chabaudi; role of macrophages and their mediators in resistance to infection with intracellular bacteria and parasites.
Tomoko Takano
tomoko [dot] takano [at] mcgill [dot] ca
(514) 398-21711
Nephrology Research
McGill University
Duff Medical Building
3775 University, Room 229
Montreal, Quebec H3A 2B4
Role of lipid mediators in glomerular epithelial cell injury, with a particular focus on the role of cyclooxygenase products. 2. Mechanisms of glomerular barrier dysfunction: role of the actin cytoskeleton. Technique used: cell biology, molecular biology, protein biochemistry, small animal experiments, lipid biochemistry.
Elena Torban
elena [dot] torban [at] mcgill [dot] ca
(514) 398-81500
Department of Medicine, Division of Experimental Medicine, Nephrology Research
McGill University
Duff Medical Building
3775 University, Room 226
Montreal, Quebec H3A 2B4
 
Simon S. Wing
simon [dot] wing [at] mcgill [dot] ca
(514) 398-41011
Department of Medicine, Division of Endocrinology & Metabolism
687 Pine Ave. We. Room M905
Montreal, Quebec
H3A 1A1
http://www.mcgill.ca/endocrinology/facultydir/wingsimon