|Department of Physiology|
McIntyre Medical Sciences Bldg, rm 1120
3655 Promenade Sir William Osler
Montréal, Québec H3A 1Y6
phone (lab): 514-398-3639
email: Anmar.Khadra [at] mcgill.ca
Laboratory web site: http://www.medicine.mcgill.ca/physio/khadralab/
Master's and Ph.D. Positions Available
Research Area: Applied Mathematics
The core focus of my research program is to understand the interactions and mechanisms underlying the behaviour of various physiological systems using mathematical and computational approaches. I use these approaches to (i) provide important insights into the cellular and molecular processes regulating these systems; (ii) test experimental hypotheses; (iii) identify targets to manipulate their dynamics; (iv) determine the causes of abnormalities exhibited by them; and (v) ultimately develop technological tools to decipher their kinetics. The mathematical models that emerge from these studies raise intriguing mathematical questions that I then analyze either numerically, using computational tools, or theoretically, using methods of nonlinear and stochastic dynamics. This work is conducted in close collaboration with several renowned national and international experimental laboratories. For more details, please visit: http://www.medicine.mcgill.ca/physio/khadralab/
Khadra and Y.X. Li, ``A Model for the Pulsatile Secretion of Gonadotropin-Releasing Hormone from Synchronized Hypothalamic Neurons'', Biophysical Journal, 91, 74-83, 2006.
Y.X. Li and A. Khadra, ``Robust Synchrony and Rhythmogenesis in Endocrine Neurons Via Autocrine Regulations in Vitro and in Vivo'', Bulletin of Mathematical Biology, 70, 2103-2125, 2008.
A. Khadra, "Synchrony Due to Parametric Averaging in Neurons Coupled by a Shared Signal'', Physica D, 238, 771-781, 2009.
A. Khadra, P. Santamaria and L. Edelstein-Keshet, ``The Role of Low Avidity T Cells in the Protection Against Type 1 Diabetes: A Modeling Investigation'', Journal of Theoretical Biology, 256, 126-141, 2009.
A. Khadra, P. Santamaria and L. Edelstein-Keshet, ``The Pathogenicity of Self-Antigen Decreases at High Levels of Autoantigenicity: A Computational Approach'', International Immunology, 22, 571-582, 2010.
A. Khadra, S. Tsai, P. Santamaria and L. Edelstein-Keshet, ``On How Monospecific Memory-Like Autoregulatory CD8+ T Cells Can Blunt Diabetogenic Autoimmunity: A Computational Approach'', Journal of Immunology, 185, 5962-5972, 2010.
Z. Yan*, A. Khadra*, S. Li, M. Tomić., A. Sherman and S.S. Stojilkovic, ``Experimental Characterization and Mathematical Modeling of the P2X7 Receptor Channel Gating'', Journal of Neuroscience, 30, 14213-14224, 2010. *Contributed equally to this work.
A. Khadra, M. Pietropaolo, G. T. Nepom and A. Sherman, ``Investigating the Role of T-Cell Avidity and Killing Efficacy in Relation to Type 1 Diabetes Prediction'', PLoS ONE, 6, e14796, 2011.
Z. Yan, A. Khadra, A. Sherman and S.S. Stojilkovic, ``Calcium-Dependent Block of P2X7 Receptor Channel Function is Allosteric'', Journal of General Physiology, 138, 437-452, 2011.