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Thomas M.S. Chang - Emeritus Professor

Department of Physiology
McGill University
McIntyre Medical Sciences Building,
Room 1004
3655 Promenade Sir William Osler
Montréal, Québec H3G 1Y6

(514) 398-3512

artcell [dot] med [at] mcgill [dot] ca

Research Area:  Artificial Cells & Organs

Research Description:

Artificial cells in biotechnology and medicine with emphasis on potential applications in medicine
Different types of artificial cells are being investigated for many medical conditions. Contents of artificial cells include enzymes, hemoglobin, cells, genetically engineered cells and other biotechnological materials. The size ranges from cellular dimensions to the higher millimetre ranges (for cell culture and genetically engineered cells) and down to the nanometer range (for blood substitutes and delivery of protein and macromolecules) and even to the macromolecular range (e.g. cross-linked hemoglobin-enzymes as blood substitutes). More details can be obtained from our website: www.artcell.mcgill.ca

Education:   M.D., Ph.D., McGill

Recent Publications:

Chang TMS.
"Artificial Cells" in "Encyclopedia of Human Biology" 2nd edition.(Editor in chief:Renalo Dulbecco).Academic Press, Inc., San Diego, CA, 1997, 457-463.

D'Agnillo F, Chang TM. (1998)
Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties.
Nat Biotechnol. Jul;16(7):667-71.

Chang, TMS (2001)
“Bioencapsulated hepatocytes for experimental liver support” Journal of Hepatology 34:148-149

Chang TMS & Prakash, S (2001)
Procedure for microencapsulationof enzymes, cells and genetically engineered microorganisms. Molecular Biotechnology 17:249-260

Powanda D & Chang TMS (2002)
Cross-linked polyhemoglobin-superoxide dismutase-catalase supplies oxygen without causing blood brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion. Artificial Cells, Blood Substitutes & Immob. Biotechnology, an international journal 30:25-42, 2002

Liu ZC & Chang TMS (2002)
Transplantation of Co-encapsulated Hepatocytes and Marrow Stem Cells into rats Artificiall Cells, Blood Substitutes & Immob. Biotechnology, an international journal 30: 99-112, 2002

Orive G, Hernandez RM, Gascon AR, Calafiore R, Chang TMS et al (2003)
Cell encapsulation: promise and progress. Nature Medicine 9:104-107

Chang, TMS (2003)
Future generations of red blood cell substitutes.  Journal of Internal Medicine   253:527-535

TMS Chang (2005) 
Therapeutic Applications of Polymeric Artificial Cells. Nature Review Drug Discovery 4:221-235


Complete publication list can be found in: http://www.medicine.mcgill.ca/artcell/changpub.pdf