Département de mathématiques et de statistique
Laboratory web site: dms.umontreal.ca/~craigm
Graduate and summer research positions available
Research Area: Mathematical medicine
Research Description: Broadly speaking, I work in quantitative medicine. My research is focused on constructing mechanistic mathematical models of physiological systems combined with drug models to optimize treatment strategies. My current projects include:
1) various studies of hematopoietic stem cell and neutrophil dynamics in health and disease,
2) PBPK/PD models of antiretroviral drugs to improve HIV treatment and prevention (PrEP) design,
3) the reconstruction of immune networks using dynamical systems techniques to understand how the production or consumption of one cytokine casually influences the up- or down-regulation of another
4) assessing phenotypic adaptive resistance in tumour cell co-cultures using game theoretic approaches
Education: B.Sc., Université de Saint-Boniface; M.Sc., University of Manitoba, Ph.D., Université de Montréal
A.R. Kirtane, O. Abouzid, D. Minaham, T. Bensel, A.L. Hill, C. Selinger, A. Bershteyn, S.S. Mo, M. Craig, H. Mazdiyasni, C. Cleveland, J. Rogner, Y-A. Lee, L. Booth, F. Javid, T. Grant, A.M. Bellinger, B. Nikolic, A. Hayward, L. Wood, P.A. Eckhoff, M. A. Nowak, R. Langer, and G. Traverso. 2018. Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy.Nature Communications, 9, 1, p. 12.
D. Câmara De Souza*, M. Craig*, T. Cassidy, J. Li, F. Nekka, J. Bélair, and A. R. Humphries. 2018. Transit and lifespan in neutrophil production: implications for drug intervention.Journal of Pharmacokinetics and Pharmacodynamics, 45, 1, p. 59-77.[*=Co-first authors]
G.P. Langlois, M. Craig, A. R. Humphries, M. C. Mackey, J.M. Mahaffy, J Bélair, T Moulin, S.R. Sinclair, and L. Wang. 2017. Normal and pathological dynamics of platelets in humans.Journal of Mathematical Biology, 75, 6-7, p. 1141-1462.
M. Craig, A.R. Humphries, and M.C. Mackey. 2016. An upper bound for the half-removal time of neutrophils from the blood.Blood, 128, 15, p. 1989-1991.
M. Craig, A. R. Humphries, and M. C. Mackey. 2016. A mathematical model of granulopoiesis incorporating the negative feedback dynamics and kinetics of G-CSF/neutrophil binding and internalization.Bulletin of Mathematical Biology, 78, 12, p. 2304-2357.