Reza Sharif Naeini

Academic title(s): 

Associate Professor

Reza Sharif Naeini
Contact Information
Email address: 
reza.sharif [at]

Department of Physiology & Cell Information Systems Group
Life Sciences Complex (Bellini), Room 171
H3G 0B1

Links: Sharif Lab - McGill University

Department of Physiology
Associate Professor, McGill University
Research areas: 
Basic Science
Areas of interest: 

We are interested in understanding the molecular bases of mechanotransduction, and the role of mechanosensory neurons in normal and pathological pain transmission. Mechanotransduction, the process through which cells convert a mechanical stimulus into an electrical signal, is of fundamental importance to physiological functions such as our senses of touch (including pain) and hearing, as well as our ability to regulate our hydromineral homeostasis (thirst), baroreflex function and myogenic tone (regulation of blood pressure). Mechanosensitive ion channels are membrane proteins responsible for most mechanotransduction processes, yet their molecular identity has not been fully resolved. Because these channels are involved in several pathologies of the nervous (chronic pain, deafness) and cardiovascular (hypertension) systems, the molecular identification of these channels, and understanding their activation properties may lead to the development of new therapeutic strategies in several clinical areas.

The projects in the lab focus on two areas of research:

1) Molecular mechanisms underlying neuronal mechanotransduction

2) Central neuronal circuits engaged by mechanosensory afferents


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