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Brian M. Gilfix, MDCM, PhD, FRCPC, DABCC, FACB Assistant Professor, McGill University |
Research:
Homocysteine and its metabolism; Inborn Errors of Metabolism (Homocystinuria); Development of Laboratory Methods in Molecular Diagnostics and HPLC
My activities are focused in three areas:
Homocysteine and its Metabolism/Inborn Errors of Metabolism (Homocystinuria) We have a large cohort of patients in my Adult Genetics Clinical with homocystinuria. We are using this opportunity to explore new treatments of homocystinuria and investigate the effect of elevated homocysteine on other risk factors for cardiovascular disease.
Development of Laboratory Methods in Molecular Diagnostics and HPLC We are developing and implementing assays based on hybridization probes to replace standard assays based on restriction fragment length polymorphism used to genotype for single nucleotide polymorphisms in the clinical laboratory. The benefit of this is decreased net cost and faster turn-around-time.
Selected Publications:
Gilfix BM. Hyperhomocysteinemia: genetic determinants and selected mouse models. Clin Invest Med 2003;26(3): 121-132.
Cianflone K, Phelis S, Davignon J, Gilfix BM. ApoE phenotype influences plasma ASP in hyperapoB subjects. Atherosclerosis. 2003 Oct;170(2):285-291.
Higgins NM, Lalonde RG, Gibbs B, Colantonio D, Gilfix B, Boulerice A, Courchesne M, Baril JG, Blank D, Sheehan NL. Québec Provincial Program for Antiretroviral Therapeutic Drug Monitoring. 16th Annual Canadian Conference on HIV/AIDS Research, Toronto, Canada; April 26-29, 2007.
Rousseau F, Lindsay C, Charland M, Bergeron J, Blanqueart I, Delage R, Gilfix B, Miron M, Mitchell GA, Oligny L. An Operational Checklist for Evaluation of Genetic tests destined to Clinical Use: Development and Description. EuroLabMed. 17th IFCC-FESCC European Congress of Clinical chemistry and Laboratory Medicine, Amsterdam, June 3- 7, 2007.