Preetha Krishnamoorthy

Preetha Krishnamoorthy, M.D. Assistant professor - Department of Pediatrics MUHC - Montreal Children's Hospital Attending physician - Division of Endocrinology & Metabolism The Montreal Children’s Hospital C-244, 2300 Tupper Street Montreal, Quebec H3H 1P3 Tel: (514) 412-4315 Fax: (514) 412-4264 preetha [dot] krishnamoorthy [at] muhc [dot] mcgill [dot] ca (Email)

Research:

1. In cystic fibrosis, defective water and chloride transport leads to viscous secretions causing scarring and destruction of multiple organs. This may result in exocrine and endocrine pancreatic insufficiency as well as in cystic fibrosis-related diabetes (CFRD). In conjunction with members of the Endocrinology and Respirology Divisions at both the MCH and Hopital Sainte-Justine, we have been studying glucose metabolism in pediatric cystic fibrosis patients from both centers. We have also been interested in determining whether markers of oxidative stress, such as glutathione, HNE-P adducts and DHN-MA, are correlated to and may be predictive of glucose metabolism in CF patients.
2. Another project that Dr. Legault and I are working on with the Respirology Division of the MCH is the use of Repaglinide in pediatric CFRD.
3. Obesity has been associated with an increased risk of asthma, atopy, and obstructive sleep apnea. Asthma and, more recently, obstructive sleep apnea (OSA), are recognized as chronic inflammatory disorders. A subset of obese subjects has the metabolic syndrome, a chronic inflammatory condition. In collaboration with members of our Respirology Division, we are in the process of investigating the risk of developing asthma in obese children with and without the metabolic syndrome. We will also compare the prevalence of atopy and OSA between these two groups using screening questionnaires.

Selected Publications:

P. Krishnamoorthy, S. Alyaarubi, S. Abish, M. Gale, P. Albequerque, N. Jabado. Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease. Pediatrics. 2006 Aug;118(2):e537-9.

P. Krishnamoorthy, C. Freeman, M. Bernstein, S. Lawrence, C. Rodd. Osteopenia in children who have undergone posterior fossa or craniospinal irradiation for brain tumors. Arch Pediatr Adolesc Med. 2004 May;158(5):491-6.

J. Richmond, P. Krishnamoorthy, E. Andremann, A. Benjamin. Epilepsy and pregnancy: an obstetric perspective. Am J Obstet Gynecol. 2004 Feb;190(2):371-9.