 |
Stéphanie Chevalier, Ph.D. Assistant Professor: McGill University, Department of Medicine |
Research:
Protein metabolism; Insulin resistance; Cancer; Aging
Our group has recently shown blunted protein anabolism in states of insulin resistance such as obesity, aging and type 2 diabetes, concurrently with decreased sensitivity of glucose metabolism. My research focuses on the regulation of protein synthesis and degradation in the fasting state and in response to postprandial stimuli, i.e. insulin and amino acids, in lung cancer patients and frail elders who experience muscle loss.
Studies are currently conducted on 1) quantifying alterations in the muscle protein synthetic and catabolic pathways in early stages of lung cancer in both the fasted and fed states, 2) assessing the presence and magnitude of insulin resistance of both glucose and protein metabolism, and altered gluconeogenesis, in more advanced lung cancer patients and 3) developing a non-invasive surrogate approach to measure muscle protein degradation to be used in frail patients, in place of muscle biopsies.
Selected Publications:
S Chevalier, SC Burgess, CR Malloy, R Gougeon, EB Marliss, JA Morais. The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism. Diabetes 55: 675-681, 2006.
S Chevalier, R Gougeon, N Choong, M Lamarche, JA Morais. Influence of adiposity in the blunted whole-body protein anabolic response with aging. J Gerontology Med Sci 61A: 156-164, 2006.
EB Marliss, S Chevalier, R Gougeon, JA Morais, M Lamarche, G Wu. Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover. Diabetologia 49: 351-359, 2006.
JA Morais, S Chevalier, R Gougeon. Protein turnover and requirements in the healthy and frail elderly. Journal of Nutrition, Health and Aging 10(4); 272-283, 2006.
S Chevalier, EB Marliss, JA Morais, M Lamarche, R Gougeon. The influence of sex on the protein anabolic response to insulin. Metabolism Clin & Exp 54:1529-1535, 2005.
S Chevalier, EB Marliss, JA Morais, M Lamarche, R Gougeon. Insulin resistance of whole-body protein metabolism in obese women. Am J Clin Nutr 82: 355-365, 2005.
S Chevalier, R Gougeon, SH Kreisman, C Cassis, JA Morais. The hyperinsulinemic amino acid clamp increases whole-body protein synthesis in young subjects. Metabolism Clin & Exp 53: 388-396, 2004.