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Jean-François Yale, M.D., CSPQ (Endocrinology) Professor, McGill Nutrition and Food Science Centre, RVH, Room H6.85 Tel: (514) 843-1665 Fax: (514) 843-1706 jean-francois [dot] yale [at] mcgill [dot] ca (Email) |
Research:
Novel treatments in diabetes.
My clinical research program includes multicentre trials on many new therapeutic agents for Type 1 and Type 2 diabetes, and several local research protocols. The multicentre studies include the assessment of various insulin analogues, inhaled insulin for Type 1 and 2 diabetes, prevention of Type 2 diabetes (ORIGIN and NAVIGATOR studies) and studies on the prevention of cardiovascular complications in diabetes (ACCORD, ORIGIN, NAVIGATOR). The major ongoing local projects are described here
Prevention of nocturnal hypoglycemia in people with Type 1 diabetes intensive insulin therapy. (Ph. D. Project) Nocturnal hypoglycemia is very frequent in people with Type 1 diabetes. The first phase (supported by the Canadian Diabetes Association) in an in-patient study assessing the ability and mechanisms of various bedtime nutritional interventions to prevent nocturnal hypoglycemia without causing morning hyperglycemia. The second phase includes a 6 month out-patient study assessing the longer term effects of the strategy found to be most effective in phase 1.
Intensive oral agent therapy. This M.Sc. project will assess whether teaching patients how to adjust the dose of their short-acting insulin secretagogue to their current glucose level and to their carbohydrate intake can lead to improvements in glucose control, compared to the more traditional approach of constant dosages of pills and constant food intake.
Diabetes Care Optimization Project. This project assesses the impact of a new program that includes a team of health professionals that verify for patients coming at the Metabolic Day Centre if the current Canadian Guidelines for the care of diabetes are followed, and intervenes as required.