Laurent Legault

Laurent Legault, M.D. Assistant Professor – Department of Pediatrics McGill University Attending Physician – MUHC-MCH-Division of Endocrinology and Metabolism Executive member – Pediatric Insulin Pump Center Head – Diabetes Clinic The Montreal Children’s Hospital C-1239 – 2300 Tupper Street Montreal, Quebec H3H 1P3 Tel: (514) 412-4400 Ext 22864 Fax: (514) 412-4264 laurent [dot] legault [at] muhc [dot] mcgill [dot] ca (Email)

Research:

1. We are now able to screen high risk families for the development of type 1 diabetes. This multicenter international study looks at the effect of nicotinamide as a potential treatment for delaying or perhaps preventing the occurrence of type 1 diabetes in high risk individuals.
2. The genetic susceptibility to type 1 diabetes is explored using linkage studies in 1st degree relatives of known type 1 diabetic patients to look at markers of high risk for type I susceptibility in this multicenter pan-Canadian study.

   Registre québécois du diabète-PI R.Barnes, feasability study on the possibility of establishing a registry for diabetes in the province of Quebec for type 1 diabetes - Co-PI

   Impact of resistance training on insulin resistance and metabolic markers in 8-12 year old obese children, in collaboration with Concordia University’s Kinesiology department (Dr Joanna Komorowski)

   Mentors in Mention-Teenage obesity intervention study (CIHR)

   Metabolic profiles of mothers and daughters 15 years after a gestational pregnancy, co-PI, CIHR--funds managed at RVH-co-PIs; Sara Meltzer and Grace Egeland (2004-2006)

   Repaglanide use in CFRD-Novo Nordisk-sponsor- (2005-)

   Principal Investigator, Characterization of early signs of atherogenesis in a teenage obese population. (sponsored by Pfizer, Canada) (2004-)

Selected Publications:

Barlund S, Vuthberson D, Nucci A on behalh of TRIGR Study group, Breastfeeding among mothers with type 1 diabetes in a primary diabetes prevention trial. Diabetologia 2006;49:170-171, 0272 suppl 1

Hamelin C, Anglin G, Quigley C and Deal CL for the Canadian Growth Hormone Advisory Committee, Genomic Imprinting in Turner Syndrome: effects on response to growth hormone and of risk of sensorineural hearing loss, J Clin Endocrinol Metab. 2006 Aug;91(8):3002-10

Fulcher GR, Gilbert RE, Yue DK et al for Lantus study. Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy, Intern J Med 2005 Sep;35(9):536-42

Jean-Pierre Chanoine; Sarah Hampl; Craig Jensen; Mark Boldrin; Jonathan Hauptman for the Orlistat study group, Effect of Orlistat on Weight and Body Composition in Obese Adolescents: A Randomized Controlled Trial. JAMA. 2005;293:2873-2883