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David Goltzman, M.D., Professor, Department of Medicine, |
Research:
Hormonal regulation of calcium and skeletal homeostasis.
The major thrust of my research is on the hormonal regulation of mineral and skeletal homeostasis. This includes the study of the interaction of cancer with the skeleton as a special focus. In these studies the major hormonal mediators which have been examined include parathyroid hormone, parathyroid hormone-related peptide, vitamin D and calcitonin. The approach to these investigations has been mainly biochemical, cell biological and molecular biological however integrative physiological approaches both in animals and man have also been employed. These studies have relevance to non-metastatic malignancy and malignancy which is metastatic to bone, to osteoporosis, and to both primary and secondary hyperparathyroidism and are elucidating basic mechanisms underlying these clinical disorders.
Selected Publications:
Amizuka, N., Kwan, M.Y., Goltzman, D., Ozawa, H., White, J.H. Vitamin D, differentially regulates parathyroid hormone/parathyroid hormone related peptide receptor expression in bone and cartilage. J. Clin. Invest. 103: 373-381, 1999.
El Abdaimi, K., Papavasiliou, V., Rabbani, S.A., Rhim, J.S., Goltzman, D., Kremer, R. Reversal of hypercalcemia with the vitamin D analogue EB1089 in a human model of squamous cancer, Cancer Res. 59: 3325-3328, 1999.
Aklilu, F., Gladu, J., Goltzman, D., Rabbani, S.A. Role of the mitogen activated protein kinases in the induction of parathyroid hormone related peptide. Cancer Res. 60(6): 1753-1760, 2000.
Kaji, H., Canaff, L., Lebrun, J.J., Goltzman, D., Hendy, G.N. Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type ß signaling. Proc. Natl. Acad. Sci. USA. 98: 3837-3842, 2001.
Panda, D.K., Miao, D., Tremblay, M.L., Sirois, J., Farookhi, R., Hendy, G.N., Goltzman, D. Targeted ablation of the 25-hydroxyvitamin D 1a-hydroxylase enzyme: Evidence for skeletal, reproductive and immune dysfunction. Proc. Natl. Acad. Sci. USA. 98(13): 7498-7503, 2001.
Miao, D., Tong, X.K., Chan, G., Panda, D., McPherson, P.S., Goltzman, D. PTHrP stimulates osteogenic cell proliferation through protein kinase C-activation of the Ras/mitogen activated protein kinase signaling pathway. J. Biol. Chem. 276(34): 32204-32213, 2001.