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Rob Sladek Assistant Professor McGill University and Genome Quebec, |
Research:
Current projects in the laboratory include:
The Living Microarray Project. In collaboration with H. de Sterck (Waterloo), J. Wan (Waterloo), T. Hudson (Toronto), B. Bodmann (Houston), H. Djambazian and S. Sundararajan(McGill), I am developing a high-throughout imaging platform to identify and characterize gene transcription networks in living cells. The platform is able to simultaneously image hundreds of fluorescent reporter constructs during cell division and differentiation (including myogenesis).
Functional Characterization of Risk Loci for Type 2 Diabetes. In collaboration with M. Wheeler (Toronto), J. Chicoine and A. Pramatarova (McGill), I am involved in characterizing the effects of diabetes risk loci on beta-cell physiology and particularly the effects of SLC30A8 coding variants on zinc transport, beta-cell viability and insulin secretion.
The Gene Regulation in Disease (GRID) project. In collaboration with T. Pastinen, J. Majewski and H. Chu Pham Dang (McGill), I am involved in developing strategies to identify causative genetic polymorphisms that underlie disease risk loci and determine their effects on cell physiology and gene regulation.
Nanomedicine Sensors Project. This collaboration, with Z. Mi, H. Guo, J. White, B. Lennox and P. Grutter seeks to develop novel sensors to measure nucleic acid levels. These techniques, based on atomic force microscopy and nanowires will be used to provide rapid and sensitive assays to detect single nucleotide polymorphisms and to measure gene transcription from endogenous loci in real time.
Diabetes Gene Discovery Group. This multicentre collaboration with P. Froguel, G. Rocheleau, D. Serre, M. Swiatek, C. Dina, N. Bouatia-Naji, D. Meyre, S. Cauchy, M. Vaxillaire, J. Rung, L. Shen, A. Mazur and C. Polychronakos seeks to identify genetic variants that predispose to type 2 diabetes.