Chemical Society Seminar Series-Cynthia J. Burrows, The Fenton Reaction in Cells: New Surprises for DNA and RNA (Purves Lecture)

Oxidative and nitrosative stress in cells result in DNA and RNA damage due to formation of reactive oxygen and nitrogen species (ROS and RNS). These free radicals, principally CO3•¯and NO• plus NO2•, react selectively at G and C nucleobases, respectively.