Dr. Benoit Gentil

Title: 
Assistant Professor
Dr. Benoit Gentil
Contact Information
Address: 

475 Pine Avenue West
Montreal, Quebec H2W 1S4

Email address: 
benoit.gentil [at] mcgill.ca
Laboratory: 
Laboratory of Genetics and Epigenetics in Motor Development
Areas of expertise: 

Motor development; Rare neurological disease; Genetics and epigenetics; Neurobiology; stress and stress proteins.

Students interested in pursuing training opportunities are encouraged to contact Dr. Gentil directly,providing a copy of their current resumé or curriculum vitae.

Degree(s): 
  • Postdoctoral Fellow, mentor: Walter Mushynski, dep. of biochemistry, McGill University,
  • Postdoctoral Fellow, mentor: Jean-pierre Julien, dep. of neurology and neurosurgery, McGill University,
  • Ph.D., Molecular and Cell Biology. Université Joseph Fourier, Grenoble.
  • MSc in Human Nutrition, Diplôme d’Etudes Approfondies in Physiology and Pathology of Human Nutrition, University Diderot (Paris VII).
  • Licence (BSc) in Biology and Physiology, University Joseph Fourier, Grenoble.
Research areas: 
Biomechanics and Neuroscience
Selected publications: 

Dagher R*, Massie R, Gentil BJ. MTP deficiency caused by HADHB mutations: Pathophysiology and clinical manifestations.Mol Genet Metab. 2021 May;133(1):1-7

A. Dabbaghizadeh*, A. Paré*, Z. Cheng-Boivin*, R. Dagher*, S. Minotti**, M.Dicaire, B. Brais, J. Young, H.D. Durham, B.J. Gentil. The J domain of sacsin disrupts intermediate filament assembly. Bio Rxiv 2021.

D.L. Demy, M.L. Campanari, R. Munoz-Ruiz, H.D. Durham, B.J. Gentil, E. Kabashi, Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish, Cells, 9(2020).

R. Kuta, N. Larochelle, M. Fernandez, A. Pal, S. Minotti, M. Tibshirani*, K. St Louis, B.J. Gentil, J.N. Nalbantoglu, A. Hermann, H.D. Durham, Depending on the stress, histone deacetylase inhibitors act as heatshock protein co-inducers in motor neuronsand potentiate arimoclomol, exerting neuroprotection throughmultiple mechanisms in ALS modelsCell Stress Chaperones 25 (2020) 173-191.

J.Baudier, B.J. Gentil, The S100B Proteinand Partners in Adipocyte Responseto Cold Stressand Adaptive Thermogenesis: Facts, Hypotheses, and Perspectives. Biomolecules 10 (2020).

B.J. Gentil, G.T. Lai *, M. Menade,R. Lariviere, S. Minotti**, K. Gehring, J.P. Chapple, B. Brais, H.D. Durham, Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics FASEB J 33 (2019) 2982-2994.

M. Tibshirani, B. Zhao, B.J. Gentil, S. Minotti, C. Marques, J. Keith, E. Rogaeva, L. Zinman, C. Rouaux, J. Robertson, H.D. Durham, Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis Hum Mol Genet 26 (2017) 4142-4152.

B.J. Gentil, E. O'Ferrall, C. Chalk, L.F. Santana, H.D. Durham, R. Massie, A New Mutationin FIG4 Causes a SevereForm of CMT4J Involving TRPV4 in the Pathogenic CascadeJ Neuropathol Exp Neurol 76 (2017) 789-799.

E.J. Duncan, R. Lariviere, T.Y. Bradshaw, F. Longo, N. Sgarioto, M.J. Hayes, L.E.L. Romano,S. Nethisinghe, P. Giunti, M.B. Bruntraeger, H.D. Durham, B. Brais, F. Maltecca, B.J. Gentil, J.P. Chapple,Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin Hum Mol Genet 26 (2017) 3130-3143.

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