René St-Arnaud

rst-arnaud [at] (Email)
Rene St-Arnaud

René St-Arnaud, Ph.D.
Professor of Medicine, Surgery, and Human Genetics, McGill University
Associate Member, Faculty of Dentistry, McGill University

Acting Director of Research
Shriners Hospital for Children – Canada
1529 Cedar Avenue
Montreal (Quebec) H3G 1A6

Research Group:

3 Research Assistants
2 Post-doctoral trainees
5 Graduate students

Academic Career

Dr. St-Arnaud graduated from Laval University (Quebec City, Canada) with a Ph.D. in Physiology in 1986. Following post-doctoral training in molecular biology at the University of Ottawa (86-88) and at the State University of New York at Stony Brook (88-89), Dr. St-Arnaud joined the Genetics Unit of the Shriners Hospital for Children in Montreal, Canada, in 1989, where he is currently Acting Director of Research and Senior Investigator. Dr. St-Arnaud also holds cross-appointments as a tenured Full Professor of Medicine, Surgery, and Human Genetics at McGill University, where he is also cross-appointed to the Faculty of Dentistry.

Research Awards and Distinctions

Dr. St-Arnaud has held a competitive Scholarship from the Quebec Medical Research Council (FRSQ) from 1991 to 2004, and was awarded the Fuller-Albright Young Insvestigator award from the American Society for Bone and Mineral Research (1997), the Outstanding Investigator Award in the Bone Field from the International Bone and Calcium Institute (1997), and the Excellence Award from the Foundation for Research on Children’s Diseases (2003). He currently sits on the editorial boards of the journals Gene, Bone and Calcified Tissue International. Dr. St-Arnaud chaired the Gordon Conference on Bones & Teeth in 2005 and served as Councilor for the American Society for Bone and Mineral Research (2006-09). He was appointed Director of the Network for Oral and Bone Health Research in August of 2008 and serves on the Council of the Canadian Council on Animal Care. He is the immediate past-President of the Association of Osteobiology and the President of Advances in Mineral Metabolism (2011-2013).

Research Interests

We are interested in the control of gene expression in bone cells as well as in vitamin D metabolism. My laboratory uses state-of-the-art techniques in molecular biology and molecular genetics to identify and characterize regulators of gene expression in osteoblasts and to develop animal models of metabolic bone disease. My group has made significant contributions to our understanding of bone cell differentiation and function: we have cloned the 25-hydroxyvitamin D-1-alpha-hydroxylase gene (Cyp27b1), characterized the role of the aNAC transcriptional coregulator molecule in bone, isolated and characterized the Factor Inhibiting ATF4-mediated Transcription, and cloned a novel membrane receptor for 24,25-dihydroxyvitamin D. Our long-term goals include the study of the molecular mechanisms and signal transduction cascades involving the genes that we have cloned, in order to identify ‘druggable’ targets for the treatment of fractures and metabolic bone diseases.

Publication Summary

Dr. St-Arnaud has published over 100 peer-reviewed articles in scientific journals and authored more than 30 book chapters.



St-Arnaud, R., Walker, P., Kelly, P.A. and Labrie, F. 1983. Rat ovarian epidermal growth factor receptors: characterization and hormonal regulation. Mol. Cell. Endocrinol. 31: 43-52.

St-Arnaud, R., Chabot, J.-G., Labrie, F. and Walker, P. 1984. Le facteur de croissance épidermique (epidermal growth factor): structure, localisation, phosphorylation et régulation de son récepteur. Biochimie 66: 515-531.

Chabot, J.-G., St-Arnaud, R., Walker, P. and Pelletier, G. 1986. Distribution of epidermal growth factor receptors in the rat ovary. Mol. Cell. Endocrinol. 44: 99-108.

Labrie, F., Dupont, A., Bélanger, A., St-Arnaud, R., Giguère, M., Lacoursière, Y., Emond, J. and Monfette, G. 1986. Treatment of prostate cancer with gonadotropin-releasing hormone agonists. Endocrine Rev. 7: 67-77.

St-Arnaud, R., Lachance, R., Dupont, A. and Labrie, F. 1986. Serum luteinizing hormone (LH) biological activity in castrated patients with cancer of the prostate receiving a pure antiandrogen and in estrogen-pretreated patients treated with an LH-releasing hormone agonist and antiandrogen. J. Clin. Endocrinol. Metab. 63: 297-302.

St-Arnaud, R., Lachance, R., Kelly, S.J., Bélanger, A., Dupont, A. and Labrie, F. 1986. Loss of luteinizing hormone (LH) bioactivity in patients with prostatic cancer treated with an LHRH agonist and a pure antiandrogen. Clin. Endocrinol. 24: 21-30.

St-Arnaud, R., Lachance, R., Dupont, A. and Labrie, F. 1986. Stimulation of the circulating levels of glycoprotein hormone alpha-subunits after combined administration of a luteinizing hormone-releasing hormone (LHRH) agonist and Flutamide in patients with cancer of the prostate. Clin. Invest. Med. 9: 215-221.

St-Arnaud, R., Lachance, R. and Labrie, F. 1987. Characteristics of radioimmuno-assays for the alpha- and beta-subunits of human luteinizing hormone. J. Immunoassay 8: 97-114.

St-Arnaud, R., Poyet, P., Walker, P. and Labrie, F. 1988. Androgens modulate epidermal growth factor receptor levels in the rat ventral prostate. Mol. Cell. Endocrinol. 56: 21-27.

Lacoste, D., St-Arnaud, R., Bélanger, A. and Labrie, F. 1988. A pure antiandrogen does not interfere with the LHRH agonist-induced blockade of testicular androgen secretion in the dog. Mol. Cell. Endocrinol. 56: 141-147.

Crim, L.W., St-Arnaud, R., Lavoie, M. and Labrie, F. 1988. A study of LHRH receptors in the pituitary gland of the winter flounder (Pseudopleuronectes americanus Walbaum). Gen. Compar. Endocrinol. 69: 372-377.

Lacoste, D., St-Arnaud, R., Caron, S., Bélanger, A. and Labrie, F. 1988. The rise in testicular androgens during the first days of treatment with an LHRH agonist in the dog can be blocked by aminoglutethimide or ketoconazole. J. Steroid Biochem. 31: 963-970.

St-Arnaud, R., Nepveu, A., Marcu, K.B. and McBurney, M.W. 1988. Two transient increases in c-myc gene expression during neuroectodermal differentiation of mouse embryonal carcinoma cells. Oncogene 3: 553-559.

St-Arnaud, R., Craig, J., McBurney, M.W. and Papkoff, J. 1989. The int-1 proto-oncogene is transcriptionally activated during neuroectodermal differentiation of P19 mouse embryonal carcinoma cells. Oncogene 4: 1077-1080.


Candeliere, G.A., Prud'homme, J. and St-Arnaud, R. 1991. Differential stimulation of fos and jun family members by calcitriol in osteoblastic cells. Mol. Endocrinol. 5: 1780-1788.

Yotov, W.V. and St-Arnaud, R. 1992. Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-1 (HMG1). Nucl. Acids Res. 20: 3516.

St-Arnaud, R. and Moir, J.M. 1993. Wnt-1 inducing factor-1 (WiF-1): A novel G/C box-binding transcription factor regulating the expression of Wnt-1 during neuroectodermal differentiation. Mol. Cell. Biol. 13: 1590-1598.

Yotov, W.V. and St-Arnaud, R. 1993. Mitochondrial ATP synthase. Cloning and functional expression analysis of the alpha subunit of mouse ATP synthase. Biochem. Biophys. Res. Comm. 191: 142-148.

St-Arnaud, R. 1993. Fonction osseuse: fos et les autres. Médecine/Sciences 9: 1243-1246.

Sutherland, L.C., R. St-Arnaud, and M.W. McBurney. 1995. An upstream activator sequence regulates the murine pgk-1 promoter and binds multiple nuclear proteins. Gene Expression 4: 265-279.

Candeliere, G.A., F.H. Glorieux, J. Prud’homme, and R. St-Arnaud. 1995. Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia. N. Engl. J. Med. 332: 1546-1551.

St-Arnaud, R. 1995. Expression anormale du proto-oncogène c-fos dans l’os atteint de dysplasie fibreuse. Médecine/Sciences 9: 1342-1343.

St-Arnaud, R., J. Prud’homme, C. Leung-Hagesteijn, and S. Dedhar. 1995. Constitutive expression of calreticulin in osteoblasts inhibits mineralization. J. Cell Biol. 131: 1351-1359.

Candeliere, G.A., P.W. Jurutka, M.R. Haussler, and R. St-Arnaud. 1996. A composite element binding the vitamin D receptor, Retinoid X Receptor a, and a member of the CTF/NF-1 family of transcription factor mediates the vitamin D-responsiveness of the c-fos promoter. Mol. Cell. Biol. 16: 584-592.

Yotov, W.V., and R. St-Arnaud. 1996. Mapping of the human gene for the alpha-NAC/1.9.2 transcriptional coactivator to chromosome 12q23-24.1. Mammalian Genome 7: 163-164.

Yotov, W.V., and R. St-Arnaud. 1996. Fine mapping of the alpha-NAC gene (Naca) to the distal end (D2-D3) of mouse chromosome 10. Mammalian Genome 7: 240.

Yotov, W.V. and R. St-Arnaud. 1996. Differential splicing-in of a proline-rich exon converts aNAC into a muscle-specific transcription factor. Genes Dev. 10: 1763-1772.

St-Arnaud, R., G.A. Candeliere, and S. Dedhar. 1996. New mechanisms of regulation of the genomic actions of vitamin D in bone cells: interaction of the vitamin D receptor with non-classical response elements and with the multifunctional protein, calreticulin. Frontiers in Bioscience 1: 176-187.

Coppolino, M.R., M.J. Woodside, N. Demaurex, S. Grinstein, R. St-Arnaud, and S. Dedhar. 1997. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature 386:843-847.

Masuyama, H., C.M. Brownfield, R. St-Arnaud, and P.N. MacDonald. 1997. Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction. Mol. Endocrinol. 11: 1507-1517.

St-Arnaud, R., S. Messerlian, J.M. Moir, J.L. Omdahl, and F.H. Glorieux. 1997. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. J. Bone Miner. Res. 12: 1552-1559.

Yotov, W.V., A. Moreau, and R. St-Arnaud. 1998. The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. Mol. Cell. Biol. 18: 1303-1311.

Moreau, A., W.V. Yotov, F.H. Glorieux and R. St-Arnaud. 1998. Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription. Mol. Cell. Biol. 18: 1312-1321.

St-Arnaud, R. and I. Quélo. 1998. Transcriptional coactivators potentiating AP-1 function in bone. Frontiers in Bioscience 3: 838-848.

St-Arnaud, R. 1998. Transcriptional regulation during mesenchymal cell differentiation. Crit. Rev. Eukar. Gene Expr. 8: 191-202.

St-Arnaud, R. and F.H. Glorieux. 1998. Editorial: 24,25-dihydroxyvitamin D: active metabolite or inactive catabolite ? Endocrinology 139: 3371-3374.

St-Arnaud, R. 1999. Novel findings about 24,25-dihydroxyvitamin D: an active metabolite? Curr Opin Nephrol Hyper 8: 435-411.

St-Arnaud, R. 1999. Dual functions for transcriptional regulators: myth or reality? J. Cell. Biochem. Suppl. 32-33: 32-40.


Messerlian, S., X. Gao, and R. St-Arnaud. 2000. The 3-epi- and 24-oxo- derivatives of 1a,25-dihydroxyvitamin D3 activate transcription of vitamin D-responsive genes through the vitamin D receptor. J Steroid Biochem Mol Biol 72: 29-34.

Rauch, F., J. Prud'homme, A. Arabian, S. Dedhar, and R. St-Arnaud. 2000. Heart, brain, and body wall defects in calreticulin-deficient mice. Exp Cell Res 256: 105-111.

Faraonio, R., P. Moffatt, O. LaRochelle, H.M. Schipper, R. St-Arnaud, and C. Séguin. 2000. Characterization of cis-acting elements in the promoter of the mouse metallothionein-3 gene. Activation of gene expression during neuronal differentiation of P19 embryonal carcinoma cells. Eur. J. Biochem. 267: 1743-1753.

Overgergh, L., B. Decallonne, D. Valckx, A. Verstuyf, J. Depovere, J. Laureys, O. Rutgeerts, R. St-Arnaud, R. Bouillon, and C. Mathieu. 2000. Identification and immune regulation of 25-hydroxyvitamin D-1-a-hydroxylase in murine macrophages. Clin. Exp. Immunol. 120: 139-146.

St-Arnaud, R., A. Arabian, R. Travers, F. Barletta, M. Raval-Pandya, K. Chapin, J. Depovere, C. Mathieu, S. Christakos, M.B. Demay, and F.H. Glorieux. 2000. Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D. Endocrinology 141: 2658-2666.


Dardenne, O., J. Prud’homme, A. Arabian, F.H. Glorieux, and R. St-Arnaud. 2001. Targeted inactivation of the 25-hydroxyvitamin D3-1a-hydroxylase gene (CYP27B1) creates an animal model of pseudo vitamin D deficiency rickets. Endocrinology 142: 3135-3141.

Gao, X., T. Chandra, M.-O. Gratton, I. Quélo, J. Prud’homme, S. Stifani, and R. St-Arnaud. 2001. HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program. J. Cell Biol. 154: 1161-1172.

St-Arnaud, R., O. Dardenne, and F.H. Glorieux. 2001. Etiologie moléculaire des rachitismes vitamino-dépendents héréditaires. Médecine/Sciences 17: 1289-1296.


van Abel, M., J.G.J. Hoenderop, O. Dardenne, R. St-Arnaud, C.H. van Os, J.P.T.M. van Leeuwen, and R.J.M. Bindels. 2002. 1,25(OH)2D3-independent stimulatory effect of oestrogen on the expression of ECaC1 in kidney. J. Am. Soc. Nephrol. 13: 2102-2109.

Hoenderop, J.G.J., O. Dardenne, M. van Abel, A.W. van der Kemp, C.H. van Os, R. St-Arnaud, and R.J.M. Bindels. 2002. Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1a-hydroxylase knockout mice. FASEB J. 16: 1398-1406.

Goatley, L.C., S.R.F. Twigg, J.E. Miskin, P. Monaghan, R. St-Arnaud, G.L. Smith, and L.K. Dixon. 2002. The African swine fever virus protein j4R binds to the alpha chain of Nascent Polypeptide-Associated Complex. J. Virol. 76: 9991-9999.

Quélo, I., M. Hurtubise, and R. St-Arnaud. 2002. aNAC requires an interaction with c-Jun to exert its transcriptional coactivation. Gene Expression 10: 255-262.


Dardenne, O., J. Prud’homme, S.A. Hacking, F.H. Glorieux, and R. St-Arnaud. 2003. Rescue of the Pseudo Vitamin D Deficiency Rickets phenotype of CYP27B1-deficient-mice by treatment with 1,25-dihydroxyvitamin D3: biochemical, histomorphometric, and biomechanical analyses. J. Bone Miner. Res. 18: 637-643.

Dardenne, O., J. Prud’homme, S.A. Hacking, F.H. Glorieux, and R. St-Arnaud. 2003. Correction of the abnormal mineral ion homeostasis with a high calcium, high phosphorus, high lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1a-hydroxylase (CYP27B1). Bone 32: 332-340.

Troussard, A.A., N.M. Mawji, C. Ong, A. Mui, R. St-Arnaud, and S. Dedhar. 2003. Conditional knock-out of Integrin-Linked Kinase (ILK) demonstrates an essential role in PKB/Akt activation. J. Biol. Chem. 278: 22374-22378.

Terpstra, L., J. Prud’homme, A. Arabian, S. Takeda, G. Karsenty, S. Dedhar, and R. St-Arnaud. 2003. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the Integrin-Linked Kinase (ILK) in chondrocytes. J. Cell Biol. 162: 139-148.


Hoenderop, J.G.J., H. Chon, D. Gkika, H.A.R. Bluyssen, F.C.P. Holstege, R. St-Arnaud, B. Braam, and R.J.M. Bindels. 2004. Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1a-hydroxylase knockout mice. Kidney Int. 65: 531-539.

Bikle, D.D., S. Chang, D. Crumrine, H. Elalieh, M.-Q. Man, E.H. Choi, O. Dardenne, Z. Xie, R. St-Arnaud, K. Feingold, and P.M. Elias. 2004. 25-hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J. Invest. Dermatol. 122: 984-992.

Tenenhouse, H.S., C. Gauthier, H. Chau, and R. St-Arnaud. 2004. 1a-Hydroxylase gene ablation and Pi supplementation inhibit renal calcification in mice homozygous for the disrupted Na/Pi cotransporter gene Npt2a. Am. J. Physiol.: Renal Physiol. 286: F675-681.

Quélo, I., O. Akhouayri, J. Prud’homme, and R. St-Arnaud. 2004. GSK3b-dependent phosphorylation of the aNAC coactivator regulates its nuclear translocation and proteasome-mediated degradation. Biochemistry 43: 2906-2914.

Friedrich, E.B., E. Liu, S. Sinha, S. Cook, D.S. Milstone, C.A. MacRae, M. Mariotti, P.J. Kuhlencordt, T. Force, A. Rosenzweig, R. St-Arnaud, S. Dedhar, and R.E. Gerszten. 2004. Integrin-Linked Kinase regulates endothelial cell survival and vascular development. Mol. Cell. Biol. 24: 8134-8144.

Quélo, I., C. Gauthier, G.E. Hannigan, S. Dedhar, and R. St-Arnaud. 2004. Integrin-Linked Kinase (ILK) regulates the nuclear entry of the c-Jun coactivator aNAC and its coactivation potency. J. Biol. Chem. 279: 43893-43899.


Masuda, S., V. Byford, A. Arabian, Y. Sakai, M.B. Demay, R. St-Arnaud, and G. Jones. 2005. Altered pharmacokinetics of 1a,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse. Endocrinology 146: 825-834.

Capuano, P., C.A. Wagner, T. Radanovic, D. Bacic, S. Kato, R. St-Arnaud, H. Murer, and J. Biber. 2005. Intestinal and renal adaptation to a low Pi-diet of type II Na-Pi-cotransporters in VDR and 1a-OHase deficient mice. Am. J. Physiol.: Cell Physiol. 288: C429-C434.

Akhouayri, O., I. Quélo, and R. St-Arnaud. 2005. Sequence-specific DNA binding by the aNAC coactivator is required for potentiation of c-Jun-dependent transcription of the osteocalcin gene. Mol. Cell. Biol. 25: 3452-3460.

Yu, V.W.C., G. Ambartsoumian, L. Verlinden, J.M. Moir, J. Prud’homme, C. Gauthier, P.J. Roughley, and R. St-Arnaud. 2005. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. J. Cell Biol. 169: 591-601.

Quélo, I., C. Gauthier, and R. St-Arnaud. 2005. Casein Kinase II phosphorylation regulates aNAC subcellular localization and transcriptional coactivating activity. Gene Expression 12: 159-163.

St-Arnaud, R. 2005. Ubiquitin Ligase: What Is Your True Substrate? IBMS BoneKEy July;2(7):6-10. doi:10.1138/20050169.

Razzaque, M.S., R. St-Arnaud, T. Taguchi, and B. Lanske. 2005. FGF-23, vitamin D and calcification: the unholy triad. Nephrol. Dial. Transplant. 20: 2032-2035.

Lopez, S., L. Stuhl, S. Fichelson, A. Dubart-Kupperschmitt, R. St-Arnaud, J.-R. Galindo, A. Murati, N. Berda, P. Dubreuil, and S. Gomez. 2005. NACA is a positive regulator of human erythroid cell differentiation. J. Cell Sci. 118: 1595-1605.

Niewmierzycka, A., J. Mills, R. St-Arnaud, S. Dedhar, and L.F. Reichardt. 2005. Integrin Linked Kinase (Ilk) deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly. J. Neuroscience 25: 7022-7031.

St-Arnaud, R., and V.W.C. Yu. 2005. FIAT véhicule de nouveaux mécanismes de contrôle transcriptionel de la masse osseuse [Inhibition of bone mass accrual by the FIAT transcriptional repressor]. Médecine / Sciences 21 : 25-26.

Chen, H., X.N. Huang, W. Yan, K. Chen, L. Guo, L. Tummalapali, S. Dedhar, R. St-Arnaud, C. Wu, and  J.L. Sepulveda. 2005. Role of the integrin-linked kinase / PINCH1 / alpha-parvin complex in cardiac myocyte hypertrophy. Lab. Invest. 85: 1342-1356.

Liu E., S. Sinha, C. Williams, M. Cyrille, E. Heller, S.B. Snapper, K. Georgopoulos, R. St-Arnaud, T. Force, S. Dedhar, and R.E. Gerszten. 2005. Targeted deletion of Integrin-Linked Kinase reveals a role in T cell chemotaxis and survival. Mol. Cell. Biol. 25: 11145-11155.

Mills, J., A. Niewmierzycka, A. Oloumi, B. Rico, R. St-Arnaud, I.R. Mackenzie, N.M. Mawji, J. Wilson, L.F. Reichardt, and S. Dedhar. 2005. Critical Role of Integrin Linked Kinase in Granule Cell Precursor Proliferation and Cerebellar Development. J. Neuroscience 26: 830-840.


Razzaque, M.S., D. Sitara, T. Taguchi, R. St-Arnaud, and B. Lanske. 2006. Premature ageing-like phenotype in fibroblast growth factor 23 (fgf-23) null mice is a vitamin D mediated process. FASEB J. 20: 720-722.

Masuda, S., S. Strugnell, J.C. Knudson, R. St-Arnaud, and G. Jones. 2006. Evidence for the activation of 1a-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1a,24-dixydroxyvitamin D2 and 1a,25-dihydroxyvitamin D2. Biochim. Biophys. Acta 1761: 221-234.

El-Aouni, C., N. Herbach, S.M. Blattner, A. Henger, M.P. Rastaldi, G. Jarad, J.H. Miner, M.J. Moeller, R. St-Arnaud, S. Dedhar, L.B. Holzman, R. Wanke, and M. Kretzler. 2006. Podocyte-specific deletion of Integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. J. Am. Soc. Nephrol. 17: 1334-1344.

Moffatt P., C.E. Smith, R. St-Arnaud, and A. Nanci. 2006. Identification of secreted and membrane proteins in the rat incisor enamel organ using a signal-trap screening approach. Eur. J. Oral. Sci. 114(Suppl.1): 139-146.

Dai, C., D.B. Stolz, S.I. Bastacky, R. St-Arnaud, C. Wu, S. Dedhar, and Y. Liu. 2006. Essential role of integrin-linked kinase in podocyte biology: bridging the integrin and slit diaphragm signaling. J. Am. Soc. Nephrol. 17: 2164-2175.

Moffatt, P., C.E. Smith, R. St-Arnaud, D. Simmons, J.T. Wright, and A. Nanci. 2006. Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium. Biochemical J. 399: 37-46.

White, D.E., P. Coutu, S. Nattel, Y.-F. Shi, J.-C. Tardif, R. St-Arnaud, S. Dedhar, and W.J. Muller. 2006. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy: a transgenic mouse model for spontaneous heart failure. Genes Dev. 20: 2355-2360.

Novak, J.P., S.-Y. Kim, J. Xu, O. Modlich, D.J. Volsky, D. Honys, J.L. Slonczewski, D.A. Bell, F.R. Blattner, E. Blumwald, M. Boerma, M. Cosio, Z. Gatalica, M. Hajduch, J. Hidalgo, R.R. McInnes, M.C. Miller III, M. Penkowa, M.S. Rolph, J. Sottosanto, R. St-Arnaud, M.J. Szego, D. Twell, and C. Wang. 2006. Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution. Biology Direct 1: 27.

Sitara, D., M.S. Razzaque, R. St-Arnaud, W. Huang, T. Taguchi, R.G. Erben, and B. Lanske. 2006. Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23 null animals. Am. J. Pathol. 169: 2161-2170.


Akhouayri, O., and R. St-Arnaud. 2007. Differential mechanisms of transcriptional regulation of the mouse osteocalcin gene by Jun family members. Calcif Tissue Int 80: 123-131.

Gkretsi, V., W.M. Mars, W.C. Bowen, L. Barua, Y. Yang, L. Guo, R. St-Arnaud, S. Dedhar, C. Wu, and G.K. Michalopoulos. 2007. Loss of Integrin Linked Kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis. Hepatology 45: 1025-1034.

Moffatt, P., G. Thomas, K. Sellin, M.-C. Bessette, F. Lafrenière, O. Akhouayri, R. St-Arnaud, and C. Lanctôt. 2007. Osteocrin is a specific ligand of the natriuretic peptide clearance receptor that modulates bone growth. J. Biol. Chem. 282: 36454-36462.

Gheyara, A.L., A. Vallejo-Illarramendi, K. Zang, L. Mei, R. St-Arnaud, S. Dedhar, L.F. Reichardt. 2007. Deletion of Integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency. Am. J. Pathol. 171: 1966-1977.


Moffatt, P., C.E. Smith, R. St-Arnaud, and A. Nanci. 2008. Characterization of Apin, a Secreted Protein Highly Expressed in Tooth-Associated Epithelia. J. Cell. Biochem. 103: 941-956.

Saeed, Z., C. Guilbault, J.B. De Sanctis, J. Henri, D. Marion, R. St-Arnaud, and D. Radzioch. 2008. Fenretinide prevents the development of osteoporosis in Cftr-KO mice. J. Cyst. Fibros. 7: 222-230.

St-Arnaud, R., A. Arabian, V.W.C. Yu, O. Akhouayri, J.C. Knutson, and S.A. Strugnell. 2008. 1α,24(S)(OH)2D2 Normalizes Bone Morphology and Serum PTH Without Hypercalcemia  in 25-Hydroxyvitamin D-1-Hydroxylase (CYP27B1)-Deficient mice, an Animal Model of Vitamin D Deficiency with Secondary Hyperparathyroidism. J. Endocrinol. Invest. 31: 711-717.

Nakrieko, K.-A., I. Welch, H. Dupuis, D. Bryce, A. Pajak, R. St-Arnaud, S. Dedhar, S. D’Souza, and L. Dagnino. 2008. Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol. Biol. Cell 19: 1462-1473.

Haque, T., N. Alam, F. Hamade, M. Kotsiopriftis, D. Lauzier, R. St-Arnaud, and R. C. Hamdy. 2008. Characterizing the BMP pathway in a wild type mouse model of Distraction Osteogenesis. Bone 42: 1144-1153.

St-Arnaud, R. 2008. The direct role of vitamin D on bone homeostasis. Arch. Biochem. Biophys. 473: 225-230.

Assi, K., J. Mills, D. Owen, C. Ong, R. St-Arnaud, S. Dedhar, and B. Salh. 2008. Integrin-linked kinase regulates cell proliferation and tumor growth in murine colitis-associated carcinogenesis. Gut 57: 931-940.

Yu, V.W.C., C. Gauthier, and R. St-Arnaud. 2008. FIAT represses bone matrix mineralization by interacting with ATF4 through its second leucine zipper. J Cell. Biochem. 105: 859-865.


Peng, X., M. Hawthorne, A. Vaishnav, R. St-Arnaud, and R.G. Mehta. 2009. 25-hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture. Breast Cancer Res Treat 113: 31-41.

Gkretsi, V., U. Apte, W.M. Mars, W.C. Bowen, J.-H. Luo, Y. Yang, Y.P. Yu, A. Orr, R. St-Arnaud, S. Dedhar, K.H. Kaestner, C. Wu, and G.K. Michalopoulos. 2009. Liver-specific ablation of Integrin Linked Kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology 48: 1932-1941.

Tucker, K.L., T. Sage, J.M. Stevens, P.A. Jordan, S. Jones, N.E. Barrett, R. St-Arnaud, J. Frampton, S. Dedhar, and J.M. Gibbins. 2009. A dual role for Integrin Linked Kinase in platelets: regulating integrin function and a-granule secretion. Blood 112: 4523-4531.

Yu, V.W.C., J. El-Hoss, and R. St-Arnaud. 2009. FIAT inhibition increases osteoblast activity by modulating ATF4-dependent functions. J Cell. Biochem. 106: 186-192.

Yu, V.W.C., O. Akhouayri, and R. St-Arnaud. 2009. FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes. Gene Expression Patterns 9: 335-340.

Naja, R.P., O Dardenne, A. Arabian, and R. St-Arnaud. 2009. Chondrocyte-specific modulation of cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development. Endocrinology 150: 4024-4032.

Alam, N., R. St-Arnaud, D. Lauzier, V. Rosen, and R.C. Hamdy. 2009. Are endogenous BMPs necessary for bone healing during distraction osteogenesis? Clin Orthop Relat Res 467: 3190-3198.


St-Arnaud, R., and V. Mandic. 2010. FIAT control of osteoblast activity. J Cell Biochem 109: 453-459.

Meury, T., O. Akhouayri, T. Jafarov, V. Mandic, and R. St-Arnaud. 2010. Nuclear aNAC influences bone matrix mineralization and osteoblast maturation in vivo. Mol Cell Biol 30: 43-53.

Lou, Y-R., F. Molnár, M. Peräkylä, S. Qiao, A.V. Kalueff, R. St-Arnaud, C. Carlberg, and P. Tuohimaa. 2010. 25-hydroxyvitamin D3 is an agonistic vitamin D receptor ligand. J Steroid Biochem Mol Biol 118: 162-170.

Pontier, S.M., L. Huck, D.E. White, J. Rayment, V. Sanguin-Gendreau, B. Hennessy, D. Zuo, R. St-Arnaud, G.B. Mills, S. Dedhar, C.J. Marshall, and W.J. Muller. 2010. Integrin-Linked Kinase plays a critical role in ErbB2 mammary tumor progression: implications for human breast cancer. Oncogene 29: 3374-3385.

Dossa, T., A. Arabian, J.J. Windle, S. Dedhar, S.L. Teitelbaum, F.P. Ross, G.D. Roodman, and R. St-Arnaud. 2010. Osteoclast-specific inactivation of the Integrin-Linked Kinase (ILK) inhibits bone resorption. J Cell Biochem 110: 960-967.


St-Arnaud, R., and R.P. Naja. 2011. Vitamin D metabolism, cartilage and bone fracture repair. Mol Cell Endocrinol: 347: 48-54.

St-Arnaud, R., A. Arabian, O. Akhouayri, J.C. Knutson, and S.A. Strugnell. 2011. Differential effects of oral doxercalciferol (Hectorolâ) or paricalcitol (Zemplarâ) in the Cyp27b1-null mouse model of uremia. Nephron Exp Nephr: 119: e67-e74 [Epub ahead of print].

Monemdjou, R., F. Vasheghani, H. Fahmi, G. Perez, M. Blati, N. Taniguchi, M. Lotz, R. St-Arnaud, J.-P. Pelletier, J. Martel-Pelletier, F. Beier, and M. Kapoor. 2012. Cartilage-specific deletion of peroxisome proliferator-activated receptor gamma results in abnormal endochondral ossification, and cartilage growth and development. Arthritis and Rheumatism 64: 1551-1561.

St-Arnaud, R., and B. Hekmatnejad. 2011. Combinatorial control of ATF4-dependent gene transcription in osteoblasts. Ann. NY Acad. Sci. 1237: 11-18.


Jafarov, T., J.W.M. Alexander, and R. St-Arnaud. 2012. aNAC interacts with histone deacetylase corepressors to control Myogenin and Osteocalcin gene expression. Biochim Biophys Acta 1819: 1208-1216.

Tourigny A., F. Charbonneau, P. Xing, R. Boukrab, G. Rousseau, R. St-Arnaud, and M.L. Brezniceanu. 2012. CYP24A1 exacerbated activity during diabetes contributes to kidney tubular apoptosis via Caspase-3 increased expression and activation. PloS One 7: e48652.


Vasheghani, F., R. Monemdjou, H. Fahmi, Y. Zhang, G. Perez, M. Blati, R. St-Arnaud, J.-P. Pelletier, F. Beier, J. Martel-Pelletier, and M. Kapoor. 2013. Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype. Am J Pathol 182: 1099-1106.

Hekmatnejad, B., C. Gauthier, and R. St-Arnaud. 2013. Control of Fiat (Factor Inhibiting ATF4-mediated Transcription) expression by Sp family transcription factors in osteoblasts. J Cell Biochem, in press.