Chemical Society Seminar: Carsten Bolm- Mechanochemistry: The use of mills in synthetic organic chemistry

Tuesday, May 7, 2024 13:00to14:30
Maass Chemistry Building OM 10, 801 rue Sherbrooke Ouest, Montreal, QC, H3A 0B8, CA


IUPAC defines a "mechano-chemical reaction" as a "chemical reaction that is induced by the direct absorption of mechanical energy".1 We are using such activation in synthesis and catalysis, where it has proven beneficial.2 Selected recent examples from our group will be presented here.3




1 IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"), Blackwell Scientific Publications, Oxford, 1997 and cited in PAC 2004, 76, 889.

2 James, S. L.; Collier, P.; Parkin, I.; Hyett, G.; Braga, D.; Maini, L.; Jones, B.; Friscic, T.; Bolm, C.; Krebs, A.: Mack, J.; Waddell, D. C.; Shearouse, W. C.; Orpen, G.; Adams, C.; Steed, J. W.; Harris, K. D. M. Chem. Soc. Rev. 2012, 41, 413.

3 (a) Pfennig, V. S.; Villella, R. C.; Nikodemus, J.; Bolm, C. Angew. Chem. Int. Ed. 2022, 61, e-202116514; (b) Puccetti, F.; Lukin, S.; Užarević, K.; Colacino, E.; Halasz, I.; Bolm, C.; Hernández, J. G. Chem. Eur. J. 2022, e202104409; (c) van Bonn, P.; Bolm, C. Synlett 2022, 33, 893; (d) van Bonn, P.; Dreßler, D.; Weitenhagen, F.; Bolm, C. ACS Sustainable Chem. Eng. 2022, 10, 1361; (e) Shi, P.; Tu, Y.; Kong, D.; Wu, P.; Ma, D.; Bolm, C. Angew. Chem. Int. Ed. 2022, 61, e202204874; (f) Kong, D.; Amer, M. M.; Bolm, C. Green Chem. 2022, 24, 3125 (g) Kong, D.; Bolm, C. Green. Chem. 2022, 24, 6476; (h) Terhorst, S.; Jansen, T.; Lengletz, T.; Bolm, C. Org. Lett. 2022, 24, 4109; (i) Xuan, M.; Schumacher, C.; Bolm, C.; Göstl, R.; Herrmann, A. Adv. Sci. 2022, 9, 2105497; (j) Amer, M. M.; Hommelsheim, R.; Schumacher, C.; Kong, D.; Bolm, C. Faraday Discus. 2023, 241, 79; (k) Schumacher, C.; Fritz, L.; Hanek, L. M.; Sidorin, V.; Brüx, D.; Bolm, C. Molecules 2023, 28, 807; (l) Hu, C.; van Bonn, P.; Demco, D. E.; Bolm, C.; Pich, A. Angew. Chem. Int. Ed. 2023, 62, e202305783; (m) Krake, E.; Backer, L.; Andres, B.; Baumann, W.; Handler, N.; Buschmann, H.; Holzgrabe, U.; Bolm, C.; Beweries, T. ACS Cent. Sci. 2023, 9, 1150; (n) van Bonn, P.; Ke, J.; Weike, C.; Ward, J. S.; Rissanen, K.; Bolm, C. CCS Chem. 2023, 5, 1737; (o) Passia, M.; Amer, M. M.; Demaerel, J.; Bolm, C. ACS Sustainable Chem. Eng. 2023, 11, 6838; (p) Bartalucci, E.; Schumacher, C.; Hendrickx, L.; Puccetti, F.; d'Anciães Almeida Silva, I.; Dervişoğlu, R.; Puttreddy, R.; Bolm, C.; Wiegand, T. Chem. Eur. J. 2023, 23, e202203466; (q) Puccetti, F.; Rinesch, T.; Suljić, S.; Rahimi, K.; Herrmann, A.; Bolm, C. Chem 2023, 9, 1318; (r) d'Anciães Almeida Silva, I.; Bartalucci, E.; Bolm, C.; Wiegand, T. Adv. Mater. 2023, 35, e202304092; (s) Schumacher, C.; Truong, K.-N.; Ward, J.; Rajala, A.; Lassila, E.; Bolm, C.; Rissanen, K. Org. Chem. Front. 2024, 11, 781; (t) Biswas, S.; Bolm, C. Org. Lett. 2024, 26, 1511; (u) Sahu, C. C.; Biswas, S.; Hommelsheim, R.; Bolm, C. RSC Mechanochemistry 2024, 1, 38; (v) Pan, S.; Mulks, F.; Wu, P.; Rissanen, K.; Bolm, C. Angew. Chem. Int. Ed. 2024, 63, e202316702.




Carsten Bolm studied chemistry at the TU Braunschweig (Germanin y) and at the University of Wisconsin, Madison (USA). After finishing his doctorate under the supervision of Manfred Reetz in Marburg (Germany), he performed postdoctoral studies with K. Barry Sharpless at MIT, Cambridge (USA). Subsequently, Carsten Bolm obtain a habilitation associated with Bernd Giese Basel (Switzerland). After a short term as Professor of Organic Chemistry at the University of Marburg (Germany), he moved to RWTH Aachen University (Germany) where he holds a chair of Organic Chemistry since 1996. His research interest is focused on synthetic organic chemistry including mechanochemistry.

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