John Hanrahan

Academic title(s): 

Professor, Department of Physiology

John Hanrahan
Contact Information

Department of Physiology
McGill University
McIntyre Medical Sciences Building,
Room 1013
3655 Promenade Sir William Osler
Montréal, Québec H3G 1Y6

Email address: 
john.hanrahan [at]
(514) 398-8320 (office)
(514) 398-4323 (laboratory)
Cell and Molecular Biology

BSc(Hon), Dalhousie; PhD, UBC; Postdoc, Yale 

Current research: 

Our main goal is to understand epithelial chloride transport at the molecular level.  Most of our effort focuses on CFTR (cystic fibrosis transmembrane conductance regulator), a low-conductance channel which mediates cAMP-stimulated chloride and bicarbonate secretion and is defective in the disease cystic fibrosis.  We use site-directed mutagenesis, electrophysiological and imaging methods to study the structure and function of CFTR in heterologous expression systems, cell lines, and primary epithelial cell cultures.  A recent emphasis has been the development of F508del-CFTR correctors for the treatment of CF. Other projects investigate the role of CFTR in mucus production and in chronic obstructive pulmonary disease. 

Selected publications: 
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